国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (2): 205-212.doi: 10.7518/gjkq.2021028

• 综述 • 上一篇    下一篇

循环肿瘤细胞与口腔鳞状细胞癌相关性的研究进展

甘建国1(),高攀2,王晓毅1()   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院头颈肿瘤外科 成都 610041
    2.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院全科门诊及急诊科 成都 610041
  • 收稿日期:2020-06-16 修回日期:2020-11-26 出版日期:2021-03-01 发布日期:2021-03-17
  • 通讯作者: 王晓毅
  • 作者简介:甘建国,硕士,Email: gandentist@qq.com
  • 基金资助:
    四川大学华西口腔医院基础与应用基础研究项目(RD-02-201914)

Research progress on the relationship between circulating tumor cells and oral squamous cell carcinoma

Gan Jianguo1(),Gao Pan2,Wang Xiaoyi1()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of General and Emergency Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-06-16 Revised:2020-11-26 Online:2021-03-01 Published:2021-03-17
  • Contact: Xiaoyi Wang
  • Supported by:
    Fund of Basic and Applied Basic Research, West China Hospital of Stomatology, Sichuan University(RD-02-201914)

摘要:

循环肿瘤细胞(CTCs)是从原发灶部位脱落、释放并转移到血液循环的肿瘤细胞,目前广泛应用于肺癌、乳腺癌等恶性肿瘤的早期诊断、治疗、疗效评价和预后判断,但是在口腔鳞状细胞癌(OSCC)中运用较少且缺乏相关的临床证据。有研究表明,CTCs是OSCC相对独立的预后指标,而且是复发或转移的重要原因之一。本文为深入阐述OSCC中CTCs的形成机制及其检测技术,探索OSCC相关CTCs生物标志物的临床意义,了解CTCs与OSCC进展及预后的关系,现就CTCs与OSCC的相关性研究作一综述。

关键词: 循环肿瘤细胞, 口腔鳞状细胞癌, 预后

Abstract:

Circulating tumour cells (CTCs) are tumour cells that disseminate from primary lesion into the peripheral circulating blood. Studies have linked CTCs to the early diagnosis, therapy, therapeutic evaluation and prognostic assessment of cancers, particularly breast and lung cancers. However, CTCs are seldom used in oral squamous cell carcinoma (OSCC), and their value in OSCC lacks clinical evidences. Current evidence has shown that CTCs are a relatively independent prognostic factor and one of the most important reasons of the recurrence and metastasis of OSCC. This paper reviews the current research status of CTCs in OSCC to further elaborate the mechanism of CTCs formation in OSCC and its detection techniques, explore the clinical importance of the biomarkers of OSCC-related CTCs and understand the progression and prognostic relationship between CTCs and OSCC.

Key words: circulating tumor cells, oral squamous cell carcinoma, prognosis

中图分类号: 

  • R782.2

表1

CTCs常用检测方法比较"

方法原理 细胞活力 特异度 敏感度 是否依赖EpCAM
免疫磁珠分离
基于细胞大小分离
微流体芯片技术 是/否
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