国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (6): 673-677.doi: 10.7518/gjkq.2018.06.009

• 材料学专栏 • 上一篇    下一篇

石墨烯及其衍生物改性复合材料促成骨机制和应用的研究进展

李婷婷,张玉峰(),王若茜,黄智庆,谢律,薛艺凡,王宇蓝   

  1. 口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室 武汉大学口腔医学院 武汉 430079
  • 收稿日期:2017-11-02 修回日期:2018-05-23 出版日期:2018-11-01 发布日期:2018-11-15
  • 通讯作者: 张玉峰 E-mail:zyf@whu.edu.cn
  • 作者简介:李婷婷,学士,Email： 2064448467@qq.com
  • 基金资助:
    武汉大学自主科研交叉项目(2042017kf0207);湖北省技术创新专项重点项目(2017AHB046)

Mechanism and application of osteogenesis induced by graphene and its derivatives modified composite materials

Tingting Li,Yufeng Zhang(),Ruoxi Wang,Zhiqing Huang,Lü Xie,Yifan Xue,Yulan Wang   

  1. State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatolgy, Wuhan University, Wuhan 430079, China
  • Received:2017-11-02 Revised:2018-05-23 Online:2018-11-01 Published:2018-11-15
  • Contact: Yufeng Zhang E-mail:zyf@whu.edu.cn
  • Supported by:
    This study was supported by Fundamental Research Funds for the Central Universities(2042017kf0207);The Special Fund for Technical Innovation of Hubei Province(2017AHB046)

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摘要：

自体或异体骨移植是治疗骨缺损的有效方法,但仍存在感染、免疫排斥等问题。骨组织工程一直致力于通过不同材料诱导干细胞向成骨方向分化,以修复各种因素造成的骨缺损。将石墨烯及其衍生物负载在支架材料上能显著增强现有支架材料的生物相容性,并促进干细胞的黏附、增殖及成骨分化。本文对近年来石墨烯及其衍生物改性复合材料在成骨分化方面应用的研究进展进行综述,为石墨烯在骨组织工程中的应用提供新思路。

关键词: 石墨烯, 石墨烯衍生物, 成骨分化, 骨再生

Abstract:

For a long time, autogenous bone graft is widely used in clinic and was verified to be effective in treating bone defects, but this technique is not perfect for the difficulty in healing of the donate site, immune rejection and infection. Bone tissue engineering approaches aims to aid the regeneration of bone tissues by filling the bone defects with different scaffolds which is able to induce the osteogenic differentiation of bone marrow stem cells. It is reported in former researches that graphene coating can significantly enhance the biocompatibility, cell adhesion and differentiation of scaffolds. In this review, we focused on the application of scaffolds modified with graphene and its derivatives to promote osteogenic differentiation published in recent years to providing new ideas for bone tissue regeneration.

Key words: graphene, grapheme derivatives, osteogenic differentiation, osteogenesis

中图分类号: 

  • R687.3 +4
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