国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (5): 597-602.doi: 10.7518/gjkq.2018.05.017

• 综述 • 上一篇    下一篇

p53相关长链非编码RNA及其与口腔癌的关系

韩曈曈,陈乔尔(),朱友明   

  1. 安徽医科大学口腔医学院 合肥 230032
  • 收稿日期:2017-10-22 修回日期:2018-03-09 出版日期:2018-09-01 发布日期:2018-09-20
  • 通讯作者: 陈乔尔 E-mail:chqe0111@163.com
  • 作者简介:韩曈曈,硕士,Email:1956133403@qq.com

Long non-coding RNA associated with p53 and the relationship with tumor

Tongtong Han,Qiaoer Chen(),Youming. Zhu   

  1. School of Stomatology, Anhui Medical University, Hefei 230032, China
  • Received:2017-10-22 Revised:2018-03-09 Online:2018-09-01 Published:2018-09-20
  • Contact: Qiaoer Chen E-mail:chqe0111@163.com

摘要:

p53基因是细胞生长的负性调节因子,正常情况下通过调控细胞的增殖和凋亡发挥抑癌作用,p53突变常导致肿瘤的发生。近年研究发现,长链非编码RNA(lncRNA)在多种肿瘤的发生发展中起到重要作用。本文将对p53相关的lncRNA在口腔癌中的研究进展进行论述,旨在为口腔癌患者的治疗提供新策略。

关键词: p53, 长链非编码RNA, 肿瘤, 口腔癌

Abstract:

p53 gene is a negative regulator of cell growth which can suppress the tumor through the regulation of cell proliferation and apoptosis under normal circumstances. The mutation of p53 often lead to the tumorigenesis. Recently, Long non-coding RNA (lncRNA) was identified as having a function role in the tumorigenesis and development of a variety of tumors. The review aimed to discuss the relationship of LncRNA which associated with p53 and oral cancer, and provide new strategies for patients with oral cancer.

Key words: p53, long non-coding RNA, tumors, oral cancer

中图分类号: 

  • R782
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