国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (6): 664-668.doi: 10.7518/gjkq.2017.06.008

• 牙周专栏 • 上一篇    下一篇

炎性衰老在糖尿病牙周炎中的作用机制及研究现状

张鹏1, 丁一2, 王琪1   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心,四川大学华西口腔医院修复科 成都 610041;
    2.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2017-04-10 修回日期:2017-08-15 出版日期:2017-11-01 发布日期:2017-11-01
  • 通讯作者: 王琪,副教授,博士,Email：wqinno8751@gmail.com
  • 作者简介:张鹏,硕士,Email：pengno1@qq.com
  • 基金资助:
    国家自然科学基金（81200794）; 成都市国际科技合作项目（2015-GH02-00035-HZ）

Research on the role of inflammaging in diabetes mellitus-associated periodontitis

Zhang Peng1, Ding Yi2, Wang Qi1   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-04-10 Revised:2017-08-15 Online:2017-11-01 Published:2017-11-01
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81200794) and International Cooperation Project of Chengdu Municipal Science and Technology Bureau(2015-GH02-00035-HZ).

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摘要： 糖尿病牙周炎近来被认为是一种衰老相关疾病,其预防和控制是临床治疗的难点。炎性衰老目前被发现是糖尿病并发症发生和发展的重要因素。本文就炎性衰老及其在糖尿病牙周炎中潜在作用机制进行综述,为研究糖尿病患者牙周炎发生发展的机制和治疗方法提供新的思路。

关键词: 糖尿病牙周炎, 炎性衰老, 氧化应激, 炎性细胞因子, DNA损伤, 自噬

Abstract: Diabetes mellitus-associated periodontitis is a common age-related disease. However, methods for the prevention and treatment of this disease need further development. Inflammaging has been recently raised as an important factor in the occurrence and development of diabetic complications. This paper reviewed the relevant literature about the research and mechanism on the role of inflammaging in diabetes mellitus-associated periodontitis and provided the new approach for pathogenesis and treatment of periodontitis inpatients with diabetes.

Key words: diabetes mellitus-associated periodontitis, inflammaging, oxidative stress, inflammatory cytokines, DNA damage, autophagy

中图分类号: 

  • R781.4
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