脱细胞异体真皮基质在牙周病学中的应用

doi:10.7518/gjkq.2017.06.009

摘要/Abstract

摘要： 脱细胞异体真皮基质（ADM）是通过物理化学方法处理供体皮肤,脱去其表皮层中所有细胞成分,而获取的结缔组织基质成分,因而ADM保留了细胞外基质的生化特性和三维空间框架结构,具有组织相容性,可用于修复组织缺损及牙周组织再生。ADM作为一种创伤修复材料,被广泛应用于医学领域,已有体外培养、动物实验和临床试验等相关研究,本文将对ADM的材料特性、作用机制以及在牙周病学中的应用作一综述。

关键词: 脱细胞异体真皮基质, 组织再生, 牙周病学

Abstract: Acellular dermal matrix(ADM) is produced by a progress that removed cell component and preserved the dermis, which reserved properties of extracellular matrix and retained structural architecture. With good histocompatibility, ADM could be applied to restore tissue defect and guide tissue regeneration. Studies in vitro, in vivo and clinical trials showed that ADM had been widely used in medicine as a repair material. This review summarized the progress of ADM on the properties, mechanisms and applications in periodontology.

Key words: acellular dermal matrix, tissue regeneration, periodontology

中图分类号:

R781.4

关巍, 汪昌宁. 脱细胞异体真皮基质在牙周病学中的应用[J]. 国际口腔医学杂志, 2017, 44(6): 669-673.

Guan Wei, Wang Changning.. Application of acellular dermal matrix in periodontology[J]. Inter J Stomatol, 2017, 44(6): 669-673.

参考文献

[1] Livesey SA, Herndon DN, Hollyoak MA, et al. Trans-planted acellular allograft dermal matrix. Potential as a template for the reconstruction of viable dermis[J]. Transplantation, 1995, 60(1):1-9.
[2] Clemens MW, Kronowitz SJ. Acellular dermal matrix in irradiated tissue expander/implant-based breast reconstruction: evidence-based review[J]. Plast Recon-str Surg, 2012, 130(5 Suppl 2):27S-34S.
[3] Aldekhayel SA, Sinno H, Gilardino MS. Acellular dermal matrix in cleft palate repair: an evidence-based review[J]. Plast Reconstr Surg, 2012, 130(1): 177-182.
[4] Chen XD, Shi Y, Shu B, et al. The effect of porcine ADM to improve the burn wound healing[J]. Int J Clin Exp Pathol, 2013, 6(11):2280-2291.
[5] Schardey HM, Di Cerbo F, von Ahnen T, et al. Delayed primary closure of contaminated abdominal wall defects with non-crosslinked porcine acellular dermal matrix compared with conventional staged repair: a retrospective study[J]. J Med Case Rep, 2014, 8:251.
[6] Pennisi E. Crystalline eyes of chitons inspire materials scientists[J]. Science, 2015, 350(6263):899.
[7] Pabst AM, Happe A, Callaway A, et al. In vitro and in vivo characterization of porcine acellular dermal matrix for gingival augmentation procedures[J]. J Periodontal Res, 2014, 49(3):371-381.
[8] 高润涛, 李景辉, 张皑峰, 等. 腮腺术中脱细胞异体真皮基质植入预防Frey’s综合征动物实验研究[J]. 现代口腔医学杂志, 2010, 24(2):111-113.
Gao RT, Li JH, Zhnag AF, et al. Observation of ace-llar dermal matrix implantation in the surgical field of parotidectomy[J]. J Modern Stomatol, 2010, 24 (2):111-113.
[9] Sclafani AP, Romo T 3rd, Jacono AA, et al. Evalua-tion of acellular dermal graft in sheet(AlloDerm) and injectable(micronized AlloDerm) forms for soft tissue augmentation. Clinical observations and histological analysis[J]. Arch Facial Plast Surg, 2000, 2(2):130- 136.
[10] 左金华, 杨佑成, 李武修, 等. 脱细胞异体真皮基质生物学特性的实验研究[J]. 临床口腔医学杂志, 2004, 20(5):276-278.
Zuo JH, Yang YC, Li WX, et al. Study on the hio-perties of allogenic acellular derunal matrix[J]. J Clin Stomatol, 2004, 20(5):276-278.
[11] Maia LP, Novaes J, Souza SL, et al. In vitro evalua-tion of acellular dermal matrix as a three-dimensional scaffold for gingival fibroblasts seeding[J]. J Perio-dontol, 2011, 82(2):293-301.
[12] Ahmedbeyli C, Ipçi ŞD, Cakar G, et al. Clinical eva-luation of coronally advanced flap with or without acellular dermal matrix graft on complete defect cove-rage for the treatment of multiple gingival recessions with thin tissue biotype[J]. J Clin Periodontol, 2014, 41(3):303-310.
[13] Moslemi N, Jazi MM, Haghighati FA, et al. Acellular dermal matrix allograft versus subepithelial connective tissue graft in treatment of gingival recessions: a 5-year randomized clinical study[J]. J Clin Periodontol, 2011, 38(12):1122-1129.
[14] Moslemi N, Heidari M, Mousavi Jazi M, et al. App-lication of an acellular dermal matrix allograft(Ceno-Derm) for treatment of multiple gingival recession defects: a case report with one-year follow-up[J]. J Dent Res Dent Clin Dent Prospects, 2014, 8(3):180- 183.
[15] Mahn DH. Esthetic correction of gingival recession using a modified tunnel technique and an acellular dermal connective tissue allograft[J]. J Esthet Restor Dent, 2002,14(1):18-23.
[16] Lin GH, Chan HL, Wang HL. The significance of keratinized mucosa on implant health: a systematic review[J]. J Periodontol, 2013, 84(12):1755-1767.
[17] Liu CY, Su YC, Tan BS, et al. Reconstruction of atta-ched soft tissue around dental implants by acelluar dermal matrix grafts and resin splint[J]. Int J Clin Exp Med, 2014, 7(12):4666-4676.
[18] Park JB. Increasing the width of keratinized mucosa around endosseous implant using acellular dermal matrix allograft[J]. Implant Dent, 2006, 15(3):275- 281.
[19] 谢旺祥, 丰章坤, 陈明福, 等. 口腔修复膜在前庭沟加深术中的应用[J]. 口腔颌面外科杂志, 2013, 23 (6):456-458.
Xie WX, Feng ZK, Chen MF, et al. Application of oral biofilm in vestibular extension[J]. J Oral Maxi-llofac Surg, 2013, 23(6):456-458.
[20] Bhola M, Newell DH, Hancock EB. Acellular dermal allograft for vestibuloplasty—an alternative to auto-genous soft tissue grafts in preprosthetic surgical procedures: a clinical report[J]. J Pros-thodont, 2003, 12(2):133-137.
[21] Talebi M, Farmanbar N, Abolfazli S, et al. Manage-ment of physiological hyperpigmentation of oral mucosa by cryosurgical treatment: a case report[J]. J Dent Res Dent Clin Dent Prospects, 2012, 6(4):148- 151.
[22] 夏静. 牙龈黑色素沉着治疗研究进展[J]. 中国实用口腔科杂志, 2014, 7(4):244-247.
Xia J. Research progress in the treatment of gingival melanin pigmentation[J]. Chin J Pract Stomatol, 2014, 7(4):244-247.
[23] Pontes AE, Pontes CC, Souza SL, et al. Evaluation of the efficacy of the acellular dermal matrix allograft with partial thickness flap in the elimination of gin-gival melanin pigmentation. A comparative clinical study with 12 months of follow-up[J]. J Esthet Restor Dent, 2006,18(3):135-143.
[24] Bottino MC, Thomas V. Membranes for periodontal regeneration—a materials perspective[J]. Front Oral Biol, 2015, 17:90-100.
[25] 陈武, 王韦玮, 时新站, 等. 脱细胞真皮基质作为屏障膜的细胞相容性及细胞封闭性的体外研究[J]. 上海口腔医学, 2013, 22(3):260-264.
Chen W, Wang WW, Shi XZ, et al. Evaluation of the biocompatibility and cell segregation performance of acellular dermal matrix as barrier membrane on guided tissue regeneration in vitro [J]. Shanghai J Stomatol, 2013, 22(3):260-264.
[26] de Andrade PF, de Souza SL, de Oliveira Macedo G, et al. Acellular dermal matrix as a membrane for guided tissue regeneration in the treatment of Class Ⅱfurcation lesions: a histometric and clinical study in dogs[J]. J Periodontol, 2007, 78(7):1288-1299.
[27] Retzepi M, Donos N. Guided bone regeneration: biological principle and therapeutic applications[J]. Clin Oral Implants Res, 2010, 21(6):567-576.
[28] 马士卿, 张旭, 孙迎春, 等. 引导骨组织再生膜的研究进展[J]. 口腔医学研究, 2016, 32(3):308-310.
Ma SQ, Zhang X, Sun YC, et al. Research progress of GBR membrane[J]. J Oral Sci Res, 2016, 32(3): 308-310.
[29] 肖红喜, 胡敏, 温伟生, 等. 牵张器结合脱细胞真皮基质增高牙槽嵴新生骨骨密度及生物力学测试实验[J]. 中华口腔医学杂志, 2008, 43(10):597-600.
Xiao HX, Hu M, Wen WS, et al. Bone density and biomechanics study of alveolar ridge augmentation with Titanium Nickel shape memory alloy distractor and aceilular dermal matrix[J]. Chin J Stomatol, 2008, 43(10):597-600.
[30] Borges GJ, Novaes AB, Grisi MF, et al. Acellular der-mal matrix as a barrier in guided bone regeneration: a clinical, radiographic and histomorphometric study in dogs[J]. Clin Oral Implants Res, 2009, 20(10): 1105-1115.
[31] 胡秀莲, 林野, 王健, 等. 应用Bio-Oss胶原与异体脱细胞真皮基质保存拔牙创硬组织的临床研究[J]. 中华口腔医学杂志, 2009, 44(9):513-516.
Hu XL, Lin Y, Wang J, et al. Clinical study of tissue preservation of extraction socket with Bio-Oss colla-gen and acellular dermal matrix[J]. Chin J Stomatol, 2009, 44(9):513-516.

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