国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (1): 55-61.doi: 10.7518/gjkq.2019.01.010

• 综述 • 上一篇    下一篇

侵袭性牙周炎唾液诊断标记物的研究进展

杨卓,张盛丹,刘程程,丁一()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周科 成都 610041
  • 收稿日期:2018-01-14 修回日期:2018-04-11 出版日期:2019-01-01 发布日期:2019-01-11
  • 通讯作者: 丁一
  • 作者简介:杨卓,硕士,Email：442198626@qq.com
  • 基金资助:
    国家重点基础研究发展计划973计划项目(2013CBA0-1700);国家自然科学基金(81371149);国家自然科学基金(81600871)

Research progress on salivary markers for diagnosis of aggressive periodontitis

Zhuo Yang,Shengdan Zhang,Chengcheng Liu,Yi Ding()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-01-14 Revised:2018-04-11 Online:2019-01-01 Published:2019-01-11
  • Contact: Yi Ding
  • Supported by:
    This study was supported by National Program on Key Basic Research Project (973 Program)(2013CBA0-1700);Natural Science Foundation of China(81371149);Natural Science Foundation of China(81600871)

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摘要：

侵袭性牙周炎是好发于青年人群,以进展迅速、破坏严重为特征,伴有家族聚集性的一类牙周炎。唾液中生物标记物能实时反映口腔软组织和硬组织、口腔内微生物的状态,在侵袭性牙周炎的诊断中有运用潜力,并可监测其活动状态。同时,唾液诊断具有廉价、无创、简便、舒适等优点。因此,唾液中的生物标记物有助于侵袭性牙周炎的早期诊断、实时监测。本文对侵袭性牙周炎唾液诊断标记物的研究现状进行综述,以期为侵袭性牙周炎唾液诊断提供思路。

关键词: 侵袭性牙周炎, 唾液, 微生物, 氧化应激, 蛋白质

Abstract:

Aggressive periodontitis is a specific form of periodontal disease with a high rate of progression and patterns of tissue destruction. This infection mostly affects young individuals and exhibits familial aggregation. Given the ability of salivary biomarkers to indicate the condition of soft tissues, bones and microorganisms in oral, salivary biomarkers may possess the potential to diagnosis and monitor aggressive periodontitis. Obtaining saliva can be low cost, noninvasive, simple and comfortable. Salivary biomarkers can be applied to early diagnosis and real-time monitoring of aggressive periodontitis. In this review, we summarise the research progression on salivary markers for aggressive periodontitis diagnosis to provide new ideas for diagnosis of such infection.

Key words: aggressive periodontitis, saliva, microbes, oxidative stress, protein

中图分类号: 

  • R781.4 +2
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