国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (6): 660-663.doi: 10.7518/gjkq.2017.06.007

• 牙周专栏 • 上一篇    下一篇

细胞焦亡与牙龈卟啉单胞菌的关系及其在牙周病发生发展中的作用机制

唐秋玲, 李格格, 潘佳慧, 侯玉帛, 孟阳, 于维先   

  1. 吉林大学口腔医院牙周病科,吉林省牙发育及颌骨重塑与再生重点实验室 长春 130021
  • 收稿日期:2017-02-07 修回日期:2017-07-15 出版日期:2017-11-01 发布日期:2017-11-01
  • 通讯作者: 于维先,教授,博士,Email:yu-wei-xian@163.com
  • 作者简介:唐秋玲,硕士,Email:1099524983@qq.com
  • 基金资助:
    国家自然科学基金面上项目(81570983); 吉林省科技厅自然科学基金项目(20150101076JC)

Mechanism of pyroptosis and Porphyromonas gingivalis in periodontitis development process

Tang Qiuling, Li Gege, Pan Jiahui, Hou Yubo, Meng Yang, Yu Weixian.   

  1. Dept. of Periodontology, School and Hospital of Stomatology, Jilin University;Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2017-02-07 Revised:2017-07-15 Online:2017-11-01 Published:2017-11-01
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81570983) and Natural Science Foundation of Science and Technology Department of Jilin Province(20150101076JC).

摘要: 细胞焦亡是一种典型的程序性细胞死亡方式,主要通过炎症小体的介导,并伴有大量促炎性细胞因子的释放。牙龈卟啉单胞菌作为牙周炎的关键致病菌,一方面可通过激活牙周组织中巨噬细胞内核苷酸结合寡聚化结构域样受体蛋白3炎症小体,促进细胞焦亡,引发牙周组织免疫病理损伤;另一方面,牙龈卟啉单胞菌通过抑制血管内皮细胞焦亡,逃逸免疫系统的杀伤作用,促进自身生存。本文就细胞焦亡及其在牙周炎中的作用机制作一综述。

关键词: 牙周炎, 细胞焦亡, 作用机制

Abstract: Pyroptosis is a typical form of programmed cell death mediated by inflammasomes. It leads to inflammatory response through the release of pro-inflammatory cytokines. Porphyromonas gingivalis is the keystone pathogen of periodontitis. On the one hand, it can activate thenucleotide-binding oligomerization domain like receptor protein 3 inflammasomes of macrophages in the periodontal tissue, and it also can promote pyroptosis that lead to the immune pathological damage of periodontal tissue; on the other hand, it restrain the pyroptosis of vascular endothelial cell and escape the killing of the immune system. In this paper, the recent progress and mechanism of pyroptosis in periodontitis are reviewed.

Key words: periodontitis, pyroptosis, mechanism

中图分类号: 

  • R781.4
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