国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (6): 660-663.doi: 10.7518/gjkq.2017.06.007
唐秋玲, 李格格, 潘佳慧, 侯玉帛, 孟阳, 于维先
Tang Qiuling, Li Gege, Pan Jiahui, Hou Yubo, Meng Yang, Yu Weixian.
摘要： 细胞焦亡是一种典型的程序性细胞死亡方式,主要通过炎症小体的介导,并伴有大量促炎性细胞因子的释放。牙龈卟啉单胞菌作为牙周炎的关键致病菌,一方面可通过激活牙周组织中巨噬细胞内核苷酸结合寡聚化结构域样受体蛋白3炎症小体,促进细胞焦亡,引发牙周组织免疫病理损伤;另一方面,牙龈卟啉单胞菌通过抑制血管内皮细胞焦亡,逃逸免疫系统的杀伤作用,促进自身生存。本文就细胞焦亡及其在牙周炎中的作用机制作一综述。
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