国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (6): 628-635.doi: 10.7518/gjkq.2017.06.002

• 微生物专栏 • 上一篇    下一篇

肠道微生物调控骨代谢的研究进展

吴琪1, 刘程程2, 郑黎薇3, 李继遥1, 周学东1, 徐欣1   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙体牙髓病科 成都 610041;
    2.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙周病科 成都 610041;
    3.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心,四川大学华西口腔医院儿童口腔科 成都 610041
  • 收稿日期:2016-12-26 修回日期:2017-07-15 出版日期:2017-11-01 发布日期:2017-11-01
  • 通讯作者: 徐欣,副教授,博士,Email:xin.xu@scu.edu.cn
  • 作者简介:吴琪,硕士,Email:893222526@qq.com
  • 基金资助:
    国家自然科学基金(81430011,81371135); 四川大学优秀青年学者基金(2015SCU04A16)

Research progress on gut microbiota regulating bone metabolism

Wu Qi1, Liu Chengcheng2, Zheng Liwei3, Li Jiyao1, Zhou Xuedong1, Xu Xin1   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
    3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-12-26 Revised:2017-07-15 Online:2017-11-01 Published:2017-11-01
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81430011, 81371135) and Scientific Research Foundation for Young Investigators, Sichuan University, China(2015SCU04A16).

摘要: 人类胃肠道内栖居着数量众多且种类繁杂的微生物群,肠道菌群稳态的维持对于宿主正常代谢活动的有序进行至关重要。随着人体微生物组研究的开展,肠道菌群变化对骨代谢活动的影响引起众多学者的关注。本文对肠道微生物与骨健康的关系、肠道微生物影响骨代谢的潜在机制以及肠道微生物对牙槽骨可能发挥的调控作用进行综述,以期为肠道微生物与骨代谢相关疾病的病因学研究以及疾病诊疗提供新的思路。

关键词: 肠道, 微生物群落, 骨代谢, 牙槽骨, 牙周炎

Abstract: Heterogeneous microbiota dwells in the human gastrointestinal tract, and the maintenance of gut microbiota homeostasis plays an important role in normal host metabolism. With advancement in studies on human microbial communities, the effects of gut microbiota on bone metabolism have been extensively investigated. This review summarizes the research progress on the association between gut microbiome and bone metabolism and focuses on the relationship between gut microbiota and bone fitness, the potential mechanisms of mutual interactions, and the relationship between intestinal microbiota and alveolar bones. Research advancement in this field not only enhances our understanding of the etiological role of gut microbiota in bone metabolism-related diseases but also possibly provides a novel approach for the management of bone diseases involving the microbiota.

Key words: gut, microbiota, bone metabolism, alveolar bone, periodontitis

中图分类号: 

  • Q939.93
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