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Table of Content

    01 January 2019, Volume 46 Issue 1 Previous Issue    Next Issue
    Expert Forum
    Repeatability of centric relation registration methods and their effect on concept development
    Yang Liu
    Inter J Stomatol. 2019, 46 (1):  1-4.  DOI: 10.7518/gjkq.2019.01.001
    Abstract ( 1576 )   HTML ( 72 )   PDF(pc) (16503KB) ( 392 )   Save

    Centric relation (CR) is the most controversial concept in dentistry. The spatial relationship of the condyle within the fossae has been widely explored, however the author believes that studies should focus on the origin of the concept, which is, a favorable mandible position for developing occlusion that can maximize the function and health of the orofacial system. With numerous techniques to test mandible functions, an ideal CR can be found via a trial and error process, starting from a suitable and repeatable reference. The author developed a highly repeatable and convenient way to record the reference mandible position with favourable clinical outcomes and better repeatability than conventional highly skill sensitive methods by modifying the registration method of a previous reference position.

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    Original Articles
    Expression of periostin and p53 in oral leukoplakia and oral squamous cell carcinoma
    Qun Li,Weiqun Guan,Yang’an Zhang,Zhichao. Huang
    Inter J Stomatol. 2019, 46 (1):  5-11.  DOI: 10.7518/gjkq.2019.01.002
    Abstract ( 1340 )   HTML ( 19 )   PDF(pc) (11572KB) ( 178 )   Save

    Objective This study aimed to investigate the expression and clinical significance of periostin and p53 in oral leukoplakia and oral squamous cell carcinoma. Methods The material for immunohistochemical studies consisted of 30 cases of normal oral mucosa, 30 cases of hyperplasia leukoplakia, 38 cases of dysplastic leukoplakia and 79 cases of oral squamous cell carcinoma. Results The index of positive cell vessels and the value of integrated optical density of periostin and p53 between every two groups, except for oral normal mucosa and hyperplasia leukoplakia, were statistically significant (P<0.05). Periostin expression in dysplastic leukoplakia and oral squamous cell carcinoma positively correlated with that of p53. Furthermore, the expression levels of periostin and p53 were significantly related to TNM stage, tumour differentiation degree and lymph node metastasis (P<0.05). Conclusion Periostin and p53 may be involved in the carcinogenesis of oral squamous cell carcinoma and associated with tumour invasion.

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    Animal research for the prognostic mechanism of traumatic temporomandibular joint ankyloses
    Jun Guo,Wei Fei,Qinghua Li
    Inter J Stomatol. 2019, 46 (1):  12-19.  DOI: 10.7518/gjkq.2019.01.003
    Abstract ( 1015 )   HTML ( 9 )   PDF(pc) (2940KB) ( 194 )   Save

    Objective To evaluate the effect of different treatment methods on the prognosis of intracapsular condylar fracture based on the animal model of intracapsular condylar fracture in miniature pig, and research the mechanism of temporomandibular joint ankylosis. Methods Fifteen miniature pigs were randomly divided into 3 groups, 5 animals (10 joints) in each group. The bilateral intracapsular condylar fractures caused by adopting the method of operation with removing the lateral part of articular disc. The animals were treated with three kinds of treatment of intracapsular fractures. 6 months postoperative, the formation of temporomandibular joint ankylosis was evaluated by gross specimen observation, imaging and histological examination. The expression of vascular endothelial growth factor (VEGF), osteocalcin (OCN), osteopontin (OPN) and bone morphogenetic protein 2 (BMP2) in temporomandibular joint specimen were detected by immunohistochemical staining. The mRNA and protein expressions of VEGF, OCN, OPN and BMP2 in temporomandi-bular joint specimen were detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western Blot respec-tively. Results The incidence of temporomandibular joint ankylosis in the experimental group was significantly lower than that in the control group (P<0.05). The mRNA and protein expression level of VEGF, OCN, OPN and BMP2 in the experi-mental group was significantly lower than that in the control group by RT-PCR and Western Blot (P<0.01). Conclusion Different treatment of intracapsular condylar fractures is closely related to the incidence of traumatic temporomandi-bular joint ankylosis. Removal of hematoma and reduction of bone wound exposure would be the key factors for prevention of temporomandibular joint ankylosis.

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    Radiographical analysis of 46 patients’ supernumerary teeth in the third molar region
    Wenjun Zhao,Yuanyuan Liu,Xiaoqi Hao,Kaili Wang,Jiayin Ren,Wenhao Guo,Guangning Zheng
    Inter J Stomatol. 2019, 46 (1):  20-25.  DOI: 10.7518/gjkq.2019.01.004
    Abstract ( 2336 )   HTML ( 28 )   PDF(pc) (2750KB) ( 600 )   Save

    Objective Throughout investigating imaging features of supernumerary teeth in the third molar region (ST-TMR), aims to conclude their radiographical characteristics. Methods In this study, 46 patients’ (55 teeth) X-ray materials (panoramic imagings or cone beam CT ) were collected and analysed, and investigated their location, morphology, size, whether or not concomitant lesions, etc.. Results The unilateral maxillary with single tooth is common (36/46), and those of the mandible, the bilateral and two teeth in the same area are rare. Twenty-one ST-TMRs’ cone beam CT show that impacted teeth are more (18/21); dismolars are more (9/21), others distribute in the lingual or buccal side, root or crown of third molar or shift to its mesial; 5 cases are close to the maxillary sinus floor, 1 case goes into pterygomaxillary joint; meanwhile its volume is smaller than that of the related third molar with different shape-forms, and the conical shape is common (13/21), others including nodular, similar premolar and similar molar; concomitant lesions include dentigerous cyst, anterior supernumerary teeth, adjacent teeth impacted, the change of periodontal bone, root resorption of adjacent teeth, adjacent teeth caries, other multiple impacted teeth, etc.. Conclusion The female is more than male in the incidence of ST-TMR, and the unilateral maxillary with single tooth is more common; cone beam CT can accurately evaluate the location, morphology, size, concomitant lesions of ST-TMR, etc., to provide the basis for clinical diagnosis and treatment.

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    Effect of video modeling on the perioperative psychological status of parents of children with cleft lip and palate
    Yuhao Liu,Na Bai,Menglong Cheng,Bing Shi,Zhihui Li,Caixia Gong
    Inter J Stomatol. 2019, 46 (1):  26-29.  DOI: 10.7518/gjkq.2019.01.005
    Abstract ( 1281 )   HTML ( 22 )   PDF(pc) (1034KB) ( 220 )   Save

    Objective To analyze the effect of video modeling on the perioperative psychological status of parents of children with cleft lip and palate. Methods Thirty-seven parents of children with cleft lip and palate were selected and all accepted video modeling intervention after admission as the control group 1. A self-made questionnaire was used to assess the cognitive level of inpatient procedures of parents before and after intervention. Another 81 parents of children with cleft lip and palate were selected and randomly divided into 2 groups. The test group including 40 patients received routine group psychological counseling and video modeling intervention after admission, whereas the control group 2 including 41 patients received only group psychological counseling. The self-made questionnaire was used to assess the cognitive level of inpatient procedures before intervention and before discharge. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess the degree of anxiety and depression of patients before discharge. SPSS 16.0 was used for data statistics and analysis. Results After intervention, the scores of the self-made questionnaire in the control group 1 and the test group were significantly higher (P<0.01; P<0.01), while the scores of the control group 2 were not significantly changed (P>0.05). Compared with the control group 2, the scores of SAS in the test group were significantly lower (P<0.05), the scores of SDS were not significantly changed (P>0.05), and the scores of the self-made questionnaire were significantly increased (P<0.01). Conclusion The implementation of video modeling in addition to routine group psychological counseling can significantly relieve the perioperative psychological status of parents of children with cleft lip and palate.

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    Reviews
    Advancements in receptor activity-modifying protein-1 for osteogenesis
    Qin Zhang,Ping Gong
    Inter J Stomatol. 2019, 46 (1):  30-36.  DOI: 10.7518/gjkq.2019.01.006
    Abstract ( 799 )   HTML ( 13 )   PDF(pc) (1301KB) ( 589 )   Save

    Under physiological conditions, the dynamic balance between bone resorption and bone formation is necessary to maintain bone tissue function. However, whether we can further accelerate or improve osteogenesis process during bone wound healing has been widely explored. Receptor activity-modifying protein-1 (RAMP1) has been extensively investigated because of its extensive biological activities, especially its effects on bone fracture repair. RAMP1 is commonly found in bone tissues and can interact with G-protein coupled receptors to modify their activities. RAMP1 also has a broader role in regulating receptor trafficking and signaling, affecting the biological characteristics of osteoblasts, such as proliferation, migration, and differentiation. Thus, this review summarizes recent studies about the effects of RAMP1 on osteogenesis.

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    Research advances in biomimetic peptides promoting tooth remineralization
    Siying Tao,Kunneng Liang,Jiyao Li
    Inter J Stomatol. 2019, 46 (1):  37-42.  DOI: 10.7518/gjkq.2019.01.007
    Abstract ( 1112 )   HTML ( 20 )   PDF(pc) (1148KB) ( 644 )   Save

    Tooth biomimetic remineralization is a key issue in both oral medicine and biomaterial science. Tooth biomimetic remineralization induced by peptides designed from human proteins which can control biomineralization, such as ameloblastin and dentin non-collagenous proteins, is a new method of tooth regeneration. Basic theories of biomimetic peptides promoting remineralization and several representative peptides are reviewed in the paper.

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    Research progress on submandibular gland branching-morphogenesis and its influencing factors in embryonic mice
    Zhikai Liu,Chunyi Wang,Chunjie Li
    Inter J Stomatol. 2019, 46 (1):  43-47.  DOI: 10.7518/gjkq.2019.01.008
    Abstract ( 938 )   HTML ( 21 )   PDF(pc) (1112KB) ( 406 )   Save

    As an important part of salivary glands, submandibular gland’s significance of clinical experiments and organ reconstruction is drawing more attention in recent years. In this paper, starting from the research status at abroad, we point out the submandibular gland and its basic concepts of branching morphogenesis. Then we introduce the relevant factors of affecting research in recent years such as the growth factors, hormone and micro RNA, etc..

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    Research progress on the seed cells in periodontal tissue regeneration
    Zhengmou Dong,Rui Liu,Luchuan Liu,Xiujie Wen
    Inter J Stomatol. 2019, 46 (1):  48-54.  DOI: 10.7518/gjkq.2019.01.009
    Abstract ( 1128 )   HTML ( 19 )   PDF(pc) (1141KB) ( 283 )   Save

    Periodontal disease is a chronic infectious disease that can lead to the destruction of periodontium and teeth loss. Following the deepening study on its pathogenesis, the key to treatment has gradually turned from preventing the disease on drugs and mechanical treatment development to promoting the periodontium regeneration and reconstruction. Periodontal tissue engineering technology is the new direction of periodontal tissue regeneration treatment. Periodontal tissue regeneration treatments contains seed cells, growth factors, and scaffold materials. The selection of seed cell group is one of the most important parts of periodontal tissue regeneration. This paper mainly introduces the research progress of seed cells in periodontal tissue regeneration.

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    Research progress on salivary markers for diagnosis of aggressive periodontitis
    Zhuo Yang,Shengdan Zhang,Chengcheng Liu,Yi Ding
    Inter J Stomatol. 2019, 46 (1):  55-61.  DOI: 10.7518/gjkq.2019.01.010
    Abstract ( 1022 )   HTML ( 15 )   PDF(pc) (1136KB) ( 511 )   Save

    Aggressive periodontitis is a specific form of periodontal disease with a high rate of progression and patterns of tissue destruction. This infection mostly affects young individuals and exhibits familial aggregation. Given the ability of salivary biomarkers to indicate the condition of soft tissues, bones and microorganisms in oral, salivary biomarkers may possess the potential to diagnosis and monitor aggressive periodontitis. Obtaining saliva can be low cost, noninvasive, simple and comfortable. Salivary biomarkers can be applied to early diagnosis and real-time monitoring of aggressive periodontitis. In this review, we summarise the research progression on salivary markers for aggressive periodontitis diagnosis to provide new ideas for diagnosis of such infection.

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    Research progress on the association between oxidative stress injury and certain oral diseases
    Donglei Wu,Jing Liu
    Inter J Stomatol. 2019, 46 (1):  62-67.  DOI: 10.7518/gjkq.2019.01.011
    Abstract ( 897 )   HTML ( 20 )   PDF(pc) (1135KB) ( 527 )   Save

    Oxidative stress is a state in which oxidation exceeds the antioxidant systems when the endogenous antioxidant system cannot effectively remove the large amount of free radicals accumulated in the body. It participates in the development of various diseases. The oral cavity is usually attacked by multiple endogenous or exogenous stimulations, which can lead to stress injury. This article reviews the research progress of oxidative stress in oral and maxillofacial regions induced by various peripheral stimuli and its correlation with related diseases, including temporomandibular disorders, masticatory muscle diseases, periodontal diseases, oral cancer and precancerous lesions. It also provides a new idea for the etiologic investigation, diagnosis and treatment of oral diseases from the perspective of oxidative stress. Moreover, it provides an update of the literature concerning the association of oxidative stress with pathological conditions related to oral cavity, focusing on the diagnostic and therapeutic importance of the tests based on saliva specimens in a preventive perspective.

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    Research progress on the adhesive properties of dental ceramic materials after Er:YAG laser irradiation
    Yepo Hou,Jie Gao
    Inter J Stomatol. 2019, 46 (1):  68-72.  DOI: 10.7518/gjkq.2019.01.012
    Abstract ( 696 )   HTML ( 10 )   PDF(pc) (1118KB) ( 223 )   Save

    Ceramic materials are widely used in the repair of dental tissue defects, given their advantages such as biological and aesthetic properties. Its adhesive property is crucial for its long-term effect. Er:YAG laser can incise the hard tissue and change the microstructure safely and efficiently, and it can be used as a new surface treatment technology for dental ceramic materials. This paper reviews the literature according to the following three aspects: mechanism for ceramic cutting with Er:YAG laser; the adhesive properties of ceramics after Er:YAG laser irradiation; and the advantages of Er:YAG laser in removing ceramic adhesive materials.

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    Complications of regenerative endodontics
    Yidi Jiang,Chenglin Wang,Ling Ye
    Inter J Stomatol. 2019, 46 (1):  73-77.  DOI: 10.7518/gjkq.2019.01.013
    Abstract ( 1123 )   HTML ( 32 )   PDF(pc) (1047KB) ( 794 )   Save

    Complications of regenerative endodontics are defined as other diseases or problems occurring during treatment or during the follow up period that may cause unfavourable evolution or consequences. With continuous advancement, regenerative endodontic procedures in immature teeth with pulp necrosis are some of the main choices for treatment. Therefore, complications of regenerative endodontics are worth clinical concern and study. It is important for patients to be informed and to give their consent when a definitive treatment plan is selected.

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    Research progress on oral manifestations of vitamin B12 deficiency
    Yan Tao,Yu Zhou,Qianming. Chen
    Inter J Stomatol. 2019, 46 (1):  78-83.  DOI: 10.7518/gjkq.2019.01.014
    Abstract ( 2184 )   HTML ( 26 )   PDF(pc) (1369KB) ( 682 )   Save

    Vitamin B12 is a cobalt-containing coordination compound and is necessary for normal hematopoiesis and nervous system function. Serum vitamin B12 lower than 148 pmol·L -1 would been diagnosed as vitamin B12 deficiency. Malabsorption is the common cause of vitamin B12 deficiency. The clinical features of vitamin B12 deficiency are complicated and vary greatly in severity, with symptoms such as anaemia, neurological features and digestive system damage. However, the clinical manifestations of a few patients are mild and concealed and easy to be ignored. Early diagnosis and treatment are important to prevent neurologic signs, which could be irreversible. Oral signs and symptoms include atrophic glossitis, recurrent aphthos ulcer, oral lichen planus and burning mouth syndrome, which may occur in the absence of symptomatic anaemia or neurological features. Patients with vitamin B12 deficiency maybe first visit the department of stomatology. The aim of this review is to summarize oral manifestations of vitamin B12 deficiency, so as to facilitate early detection, diagnosis and treatment of vitamin B12 deficiency.

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    Specialist perceptions and practices situation in dental care during pregnancy
    Min Wu,Man Liu,Shaowu Chen
    Inter J Stomatol. 2019, 46 (1):  84-88.  DOI: 10.7518/gjkq.2019.01.015
    Abstract ( 1128 )   HTML ( 23 )   PDF(pc) (1047KB) ( 415 )   Save

    Some studies have shown a possible association between maternal oral diseases and negative pregnancy outcomes. More and more oral health care guidelines and consensus statements during pregnancy suggest that oral health should be maintained during pregnancy and necessary dental treatment in pregnancy is safe and important. This article reviews specialist perceptions and behaviors situation in dental care during pregnancy.

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    Research progress on connective tissue graft
    Tingting Zhang,Juanjuan Zong
    Inter J Stomatol. 2019, 46 (1):  89-93.  DOI: 10.7518/gjkq.2019.01.016
    Abstract ( 1285 )   HTML ( 20 )   PDF(pc) (1115KB) ( 1210 )   Save

    For the subepithelial connective tissue graft predictability and stability has been considered as the gold standard procedure in the treatment of recession-type defects. Connective tissue graft is removal of free connective tissue grafts to the recipient area form the donor site, which the palate is the most commonly used. However, it was presumed that palatine mucosa thickness in individuals may be different, and the clinical situation in different the free grafts thickness should different, in the palate which the specific site obtain the free connective grafts and the method of operation are different. Thus, this paper reviews the clinical indications, selection of free grafts thickness in different clinical applications of the connective tissue graft, the measurement of the palatal mucosa, the specific site and the surgical method obtained of the connective tissue grafts.

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    Research progress on the thickness of core and veneering porcelain on the flexural strength of all-ceramic restoration
    Zhiheng Jin,Qing Li
    Inter J Stomatol. 2019, 46 (1):  94-98.  DOI: 10.7518/gjkq.2019.01.017
    Abstract ( 1050 )   HTML ( 18 )   PDF(pc) (1114KB) ( 283 )   Save

    With the increasing demand for oral esthetics, porcelain restoration has become the main trend of fixed dental prostheses. However, the mechanical strength of all-ceramic restorations composed of core porcelain and veneering porcelain is one of the concerns about clinical applications. Therefore, we should determine the effective designs of all-ceramic restorations to bear the complicated occlusal force of the oral cavity. However, the influence of the thickness of core porcelain and veneering porcelain on the flexural strength of full-ceramic restorations remains unclear. Comprehensive investigations have focused on the mechanical properties of full-ceramic restorations. Various experimental designs, backgrounds, and methods have been developed. This paper reviews previous studies and analyzes their differences.

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    Research progress on the application of surgical template and dynamic navigation system in implant dentistry
    Tingting Zhang,Jian Hu
    Inter J Stomatol. 2019, 46 (1):  99-104.  DOI: 10.7518/gjkq.2019.01.018
    Abstract ( 1709 )   HTML ( 48 )   PDF(pc) (1261KB) ( 873 )   Save

    With the help of surgical template and dynamic navigation system, prosthetic-driven implant dentistry has become reality. Furthermore, they can help realize minimal invasion and improve accuracy. These technologies might help doctors make preoperative implant planning, and achieve safe surgery by avoiding anatomic structures during operation. While both methods aim to achieve high accuracy, some errors in the clinical application are still detected. This article analyzes differences between the application of surgical template and dynamic navigation in clinics, and factors that may influence their accuracy.

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    Research progress on the prediction of the changes in soft tissue profile in orthodontic treatment
    Xu Zhang,Yanxi Li,Hanshi Li,Jieya Wei,Xinyu Yan,Wei Zheng,Yu Li
    Inter J Stomatol. 2019, 46 (1):  105-111.  DOI: 10.7518/gjkq.2019.01.019
    Abstract ( 1364 )   HTML ( 29 )   PDF(pc) (1075KB) ( 786 )   Save

    In orthodontic treatment, patients often mention facial esthetics as their principal motivation. Changes in anterior teeth in the labial-lingual direction causes the alteration of lip position and subsequent changes in soft tissue profile. Although orthodontists can control the movement amount of anterior teeth more accurately, it cannot accurately predict what changes will be produced in the soft tissue. Therefore, soft tissue profile prediction has considerable clinical significance. It is also a problem that urgently requires a solution. Thus, it is one of the most popular research topics in orthodontics. In this article, we review the principle, impact factors, reliability analysis, and existing problems of software tissue profile prediction in orthodontic treatment.

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    Research progress on maxillary protraction with skeletal anchorage in growing patients with Class Ⅲ malocclusion
    Yanli Liu,Wei Zhao,Biying Zhang,Xiaoli An
    Inter J Stomatol. 2019, 46 (1):  112-118.  DOI: 10.7518/gjkq.2019.01.020
    Abstract ( 941 )   HTML ( 14 )   PDF(pc) (1144KB) ( 635 )   Save

    Skeletal Class Ⅲ malocclusion, which has many multiple factors, is a common type of malocclusion in clinics. Maxillary protraction, an orthopedic therapeutic method, has commonly been used to treat skeletal Class Ⅲ malocclusion with maxillary deficiency in growing patients. With the extensive application of skeletal anchorage in orthodontic clinical work, maxillary protraction with skeletal anchorage has a good application prospect in the treatment of skeletal Class Ⅲmalocclusion. In comparison with dental anchored maxillary protraction, maxillary protraction with skeletal anchorage produces more bone defects and can significantly reduce or even eliminate adverse dental effects. This study reviews the research progress on maxillary protraction therapy with skeletal anchorage for skeletal Class Ⅲ malocclusion to provide a reference for clinical practice.

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    The development and education status of oral hygienists in Japan and America
    Ruqian Yang,Lei Zhao,Yi Ding
    Inter J Stomatol. 2019, 46 (1):  119-124.  DOI: 10.7518/gjkq.2019.01.021
    Abstract ( 3080 )   HTML ( 75 )   PDF(pc) (1055KB) ( 1302 )   Save

    A dental hygienist is a health professional who graduated from an accredited school. This professional is involved in clinical services, education, consultative planning and evaluation endeavours and seeks to prevent oral diseases, provide treatment for existing disease, and assist people in maintaining an optimum level of oral health. A developed system of dental hygienists has been established in more than 50 countries and has optimized the quality and efficiency of oral medical in these countries. This paper provides basic information about the history development, tasks and education of dental hygienists in America and Japan. The current situation in China has also been introduced to promote the development of China’s dentistry.

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