Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (5): 628-630.doi: 10.3969/j.issn.1673-5749.2012.05.019

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Relationship between the mood disorders of patients with oral cancers and disruptions in hypothalamicpituitary- adrenal axis

Jing Dian1, Jia Yanfei2, Liu Chuanxia3, Zhou Qizhi2.   

  1. 1. West China School of Stomatology, Sichuan University, Chengdu 610041, China; 2. Chronobiology Laboratory of State Administration of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China; 3. Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2011-10-11 Revised:2012-06-18 Online:2012-09-01 Published:2012-09-01

Abstract:

Oral cancer is the most common neoplasm of the head and neck. Patients with oral cancer show elevated prevalence rates of mood disorder. Mood disorder is a kind of‘catalyst’in the development of cancer and the prognosis predictor. Mood disorder in oral cancer may be associated with circadian disruption in hypothalamic-pituitary-adrenal(HPA) axis. Based on this analysis, we recommend that alteration of circadian rhythm of the HPA axis may play a crucial role in biology mechanism of intervention on oral cancer with mood disorder.

Key words: oral cancer, mood disorder, hypothalamic-pituitary-adrenal axis


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