Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (6): 742-748.doi: 10.7518/gjkq.2024090

• Reviews • Previous Articles    

Autophagy and its role and mechanism in osseointegration of oral implants

Mengyuan Zhang(),Hongye Lu,Qianhui Li,Ping Sun()   

  1. Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Researh Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China Supported by: Foundation:National Natural Science Foundation of China (82301072); Public Welfare Technology Project of Science Technology Department of Zhejiang Province (LGF22H140007); Interdisciplinary Research Project of Stomatology Hospital Affiliated to Zhejiang University School of Medicine (RD2022JCXK01)
  • Received:2023-12-13 Revised:2024-06-27 Online:2024-11-01 Published:2024-11-04
  • Contact: Ping Sun E-mail:3180102496@zju.edu.cn;nosleep@zju.edu.cn

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Abstract:

The interface of osseointegration is essential for the success of implants. Autophagy plays an important regulatory role in osteoimmunology and mediates bone tissue differentiation and bone remodeling on the surface of metal implants. In this paper, the association between autophagy and implant bone adhesion was reviewed to confirm the key role of autophagy in the regulation of bone hemostasis and osseointegration of implants and to provide a new therapeutic target for further improvement of the initial stability of implants.

Key words: autophagy, mitophagy, osseointegration, bone hemostasis, dental implants

CLC Number: 

  • R783.6

TrendMD: 

Fig 1

Mechanism of cellular autophagy"

Fig 2

Mechanism of autophagy regulating osteogenic differentiation on implant surface"

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