Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (4): 416-424.doi: 10.7518/gjkq.2024037

• Periodontitis • Previous Articles     Next Articles

Research progress on chitosan in periodontal disease treatment

Xingyue Wen1(),Junyu Zhao1,Chongjun Zhao1,Guixin Wang2,Ruijie Huang1()   

  1. 1.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.School of Chemical Engineering, Sichuan University, Chengdu 610065, China
  • Received:2023-08-06 Revised:2023-11-21 Online:2024-07-01 Published:2024-06-24
  • Contact: Ruijie Huang E-mail:2054287673@qq.com;hwangrj@163.com
  • Supported by:
    National Natural Science Foundation of China(21978179);Sichuan University Innovation and Entrepreneurship Training Program under Grants(C2023122912)

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Abstract:

Chitosan is the only naturally occurring cationic polysaccharide and has gradually become a focus of attention in tissue engineering due to its good biocompatibility; biodegradability; antibacterial, anti-inflammatory, anticancer, and tissue repair activity; and great drug delivery capacity. Periodontal disease, as an inflammatory and destructive di-sease, has a high prevalence and significant impact on oral health and even systemic health. In this review, we summarize the role of chitosan in periodontal therapy, including its regenerative scaffolding; drug delivery; and antibacterial, anti-inflammatory, and angiogenesis-promoting effects. We then analyze current issues and point out possible future directions for its development, aiming to provide solutions to problems encountered in periodontal disease treatment.

Key words: periodontal disease, chitosan, multidirectional scaffold, drug delivery, antibacterial properties

CLC Number: 

  • R781.4

TrendMD: 

Fig 1

The role of chitosan in periodontal treatment"

Fig 2

Mechanism of controlled drug release from chitosan scaffolds"

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