Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (3): 362-367.doi: 10.7518/gjkq.2024043

• Original Articles • Previous Articles     Next Articles

Research progress on perineural invasion of oral squamous cell carcinoma

Bingzhi Li(),Yunkun Liu,Wenxuan Wang,Zeyu Hou,Jinru Tang,Longjiang Li()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-07-17 Revised:2024-01-27 Online:2024-05-01 Published:2024-05-06
  • Contact: Longjiang Li E-mail:libingzhi25@163.com;muzili63@163.com
  • Supported by:
    National Natural Science Foundation of China(82141130)

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Abstract:

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck. OSCC seriously hampers patients’ life and health because of its invasion, metastasis, and recurrence characteristics. Perineural invasion (PNI) is a common but occult pathologic characteristic of OSCC that reduces the survival rate of patients. However, the clinical understanding of this high-rick biological behavior ability and mechanism remains insufficient. Recent studies have found that perineural invasion is a reciprocal communication between the tumor and nerves, which involves a variety of cells and molecules, and may become the target of future therapeutic intervention. This article reviews the research progress on the molecular pathological mechanism, prognostic value, and treatment of PNI in OSCC.

Key words: oral squamous cell carcinoma, perineural invasion, prognosis, molecular mechanism

CLC Number: 

  • R781

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