Int J Stomatol ›› 2024, Vol. 51 ›› Issue (3): 303-309.doi: 10.7518/gjkq.2024012

• Original Articles • Previous Articles     Next Articles

Effect of CXCL chemokines on the diagnosis and prognosis of head and neck quamous cell carcinoma

Xu Wu1(),Lintai Da1,Nite Su2,Duo Shang2,Xing’an Zhou2,Delehei Bateer2()   

  1. 1.Dept. of Oral and Maxillofacial Surgery, Hohhot Stomatological Hospital, Hohhot 010000, China
    2.Dept. of Stomato-logy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
  • Received:2023-08-25 Revised:2023-12-23 Online:2024-05-01 Published:2024-05-06
  • Contact: Delehei Bateer;
  • Supported by:
    Joint Project of Inner Mongolia Medical University(YKD2023LH032);Scientific Research Project of Universities in Inner Mongolia Autonomous Region(NJZY21634)


Objective This study investigated the expression levels of CXCL chemokines in head and neck cancer and their value as diagnostic and prognostic markers. Methods Public databases were used in the analysis of various abnormally expressed CXCL factors in head and neck cancer and their correlation with the poor prognoses of patients with head and neck cancer, and the correlation between CXCL family and immune factor infiltration was determined. Results Compared with normal tissues, CXCL is differentially expressed in head and neck squamous cell carcinoma (HNSCC) tissues and pathological stages, and it is closely related to long overall survival (OS) and immune cell infiltration in patients with HNSCC. CXCL chemokine gene function in HNSCC is mainly concentrated in chemokine activity. The KEGG pathway is mainly concentrated in cytokine-cytokine receptor interaction, and the CXCL family has a certain mutation rate in HNSCC. Conclusion Tumor bioinformatics analysis showed that the expression levels of the CXCL family in HNSCC tissues are different from those in normal tissues and correlated with immune cell infiltration and tumor prognosis, showing potential as prognostic markers for HNSCC and gene therapy targets.

Key words: chemokine, bioinformatics, squamous cell carcinoma of the head and neck, prognosis, immunoinfiltration

CLC Number: 

  • R739.81


Fig 1

The mRNA expression level heatmap of CXCL chemokines in HNSCC and normal head and neck tissues"

Fig 2

The mRNA expression levels of CXCL chemokines in HNSCC patients and normal head and neck tissues"

Fig 3

Expression level of CXCL chemokine mRNA related to pathological stage in HNSCC tissues"

Fig 4

Prognostic value of different CXCL chemokines in HNSCC patients"

Fig 5

GO and KEGG enrichment analysis results"

Fig 6

Relationship between HNSCC patients and differentially expressed CXCL chemokine gene mutations"

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