Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (4): 439-443.doi: 10.7518/gjkq.2021078

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Research status on congenital syphilitic teeth

Meng Shuhuai(),Luo Feng,Pei Xibo,Wan Qianbing()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of ProsthodonticsⅠ, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-01-05 Revised:2021-04-02 Online:2021-07-01 Published:2021-06-30
  • Contact: Qianbing Wan E-mail:2323864889@qq.com;champion@scu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81970984)

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Abstract:

Congenital syphilitic teeth (CST) refers to the invasion of tooth germs by Treponema pallidum from 1 month before birth to 1 year after birth. CST invades the enamel organ and causes enamel development disorder, resulting in the formation of enamel hypoplasia, mainly in permanent incisors, and abnormal enamel structure of the first permanent molar. Given its characteristic clinical manifestations, enamel hypoplasia can easily be confused with other diseases in clinical practice, delaying the oral and systemic treatment of patients. This article systematically introduces the clinical manifestations, pathological changes, and differential diagnosis of CST to guide the early diagnosis and treatment of congenital syphilis and CST.

Key words: congenital syphilitic teeth, enamel structural abnormality, differential diagnosis, treatment

CLC Number: 

  • R780.2

TrendMD: 

Fig 1

Congenital syphilis central incisors (left) and canines (right)"

Fig 2

Bud molars (left) and mulberry molars (right)"

[1] U.S. Preventive Services Task Force, Curry SJ, Krist AH, et al. Screening for syphilis infection in pregnant women: US preventive services task force reaffirmation recommendation statement[J]. JAMA, 2018,320(9):911-917.
doi: 10.1001/jama.2018.11785
[2] 中华人民共和国卫生健康委员会. 2019年全国法定报告传染病发病、死亡统计表[R/OL]. (2020-04-20) [2020-05-12]. http://www.nhc.gov.cn/jkj/s3578/2020041519e1bc1a944fc8ec176db600f68d1.shtml.
Health Commission of the People’s Republic of Chi-na. Statistics of incidence and death of notifiable in-fectious diseases in China in 2019[R/OL]. (2020-04-20) [2020-05-12]. http://www.nhc.gov.cn/jkj/s3578/2020041519e1bc1a944fc8ec176db600f68d1.shtml.
[3] Nelson R. Congenital syphilis and other STIs rise in the USA[J]. Lancet Infect Dis, 2018,18(11):1186-1187.
doi: 10.1016/S1473-3099(18)30618-2
[4] Nissanka-Jayasuriya EH, Odell EW, Phillips C. Dental stigmata of congenital syphilis: a historic review with present day relevance[J]. Head Neck Pathol, 2016,10(3):327-331.
doi: 10.1007/s12105-016-0703-z pmid: 26897633
[5] Wang YJ, Wu MZ, Gong XD, et al. Risk factors for congenital syphilis transmitted from mother to in-fant‒Suzhou, China, 2011-2014[J]. MMWR Morb Mortal Wkly Rep, 2019,68(10):247-250.
doi: 10.15585/mmwr.mm6810a4
[6] Mmeje O, Chow JM, Davidson L, et al. Discordant syphilis immunoassays in pregnancy: perinatal outcomes and implications for clinical management[J]. Clin Infect Dis, 2015,61(7):1049-1053.
doi: 10.1093/cid/civ445
[7] Binnicker MJ, Jespersen DJ, Rollins LO. Direct comparison of the traditional and reverse syphilis screening algorithms in a population with a low prevalence of syphilis[J]. J Clin Microbiol, 2012,50(1):148-150.
doi: 10.1128/JCM.05636-11
[8] Keuning MW, Kamp GA, Schonenberg-Meinema D, et al. Congenital syphilis, the great imitator‒case report and review[J]. Lancet Infect Dis, 2020,20(7):e173-e179.
doi: 10.1016/S1473-3099(20)30268-1
[9] Harper KN, Zuckerman MK, Harper ML, et al. The origin and antiquity of syphilis revisited: an appraisal of Old World pre-Columbian evidence for treponemal infection[J]. Am J Phys Anthropol, 2011,146(Suppl 53):99-133.
doi: 10.1002/ajpa.v146.53s
[10] Cooper JM, Sánchez PJ. Congenital syphilis[J]. Se-min Perinatol, 2018,42:176-184.
[11] Hutchinson J. Clinical lecture on heredito-syphilitic struma: and on the teeth as a means of diagnosis[J]. Br Med J, 1861,1(20):515-517.
pmid: 20743880
[12] Alfred F. Syphilitic teeth[J]. Dent Cosmos, 1884,26(1):12-25.
[13] Hillson S, Grigson C, Bond S. Dental defects of congenital syphilis[J]. Am J Phys Anthropol, 1998,107(1):25-40.
pmid: 9740299
[14] Ioannou S, Henneberg RJ, Henneberg M. Presence of dental signs of congenital syphilis in pre-modern specimens[J]. Arch Oral Biol, 2018,85:192-200.
doi: 10.1016/j.archoralbio.2017.10.017
[15] Moon H. On irregular and defective tooth development[J]. Trans Odontol Soc Great Britain, 1887,9:223-243.
[16] Bauer WH. Tooth buds and jaws in patients with congenital syphilis: correlation between distribution of treponema pallidum and tissue reaction[J]. Am J Pathol, 1944,20(2):297-319.
pmid: 19970756
[17] Reid DJ, Dean MC. Variation in modern human ena-mel formation times[J]. J Hum Evol, 2006,50(3):329-346.
pmid: 16300817
[18] Dean MC, Humphrey L, Groom A, et al. Variation in the timing of enamel formation in modern human deciduous canines[J]. Arch Oral Biol, 2020,114:104719.
doi: 10.1016/j.archoralbio.2020.104719
[19] Radu C, Soficaru AD. Dental developmental defects in a subadult from 16th‒19th centuries Bucharest, Romania[J]. Int J Paleopathol, 2016,15:33-38.
doi: 10.1016/j.ijpp.2016.08.001
[20] Kammoun R, Zmantar T, Labidi A, et al. Dental caries and hypoplastic amelogenesis imperfecta: clinical, structural, biochemical and molecular approaches[J]. Microb Pathog, 2019,135:103615.
doi: 10.1016/j.micpath.2019.103615
[21] Kim YJ, Kang J, Seymen F, et al. Alteration of exon definition causes amelogenesis imperfecta[J]. J Dent Res, 2020,99(4):410-418.
doi: 10.1177/0022034520901708
[22] Smith CE, Whitehouse LL, Poulter JA, et al. Defects in the acid phosphatase ACPT cause recessive hypoplastic amelogenesis imperfecta[J]. Eur J Hum Genet, 2017,25(8):1015-1019.
doi: 10.1038/ejhg.2017.79
[23] Bianchi ML. Hypophosphatasia: an overview of the disease and its treatment[J]. Osteoporos Int, 2015,26(12):2743-2757.
doi: 10.1007/s00198-015-3272-1 pmid: 26245849
[24] U.S. Department of Health and Human Services. Congenital syphilis‒2015 STD treatment guidelines[EB/OL]. (2015-06-04)[2020-09-12]. https://www.cdc.gov/std/tg2015/congenital.htm.
[25] Gaul JS, Grossschmidt K, Gusenbauer C, et al. A probable case of congenital syphilis from pre-Columbian Austria[J]. Anthropol Anz, 2015,72(4):451-472.
doi: 10.1127/anthranz/2015/0504
[26] Krämer N, Bui Khac NN, Lücker S, et al. Bonding strategies for MIH-affected enamel and dentin[J]. Dent Mater, 2018,34(2):331-340.
doi: 10.1016/j.dental.2017.11.015
[27] Crawford PJM, Aldred M, Blozh-Zupan A. Amelogenesis imperfecta[J]. Orphanet J Rare Dis, 2007,2(17):1750-1172.
[28] Seikaly H, Idris S, Chuka R, et al. The Alberta reconstructive technique: an occlusion-driven and di-gitally based jaw reconstruction[J]. Laryngoscope, 2019,129(Suppl 4):S1-S14.
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[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
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[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
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[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .