Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (4): 431-436.doi: 10.7518/gjkq.2019054

• Reviews • Previous Articles     Next Articles

Effect of epigallocatechin-3-gallate on stem cell proliferation and osteogenic differentiation

Mei Hongxiang1,Zhang Yidan1,Zhang Chenghao2,Liu Enyan1,Chen Hao1,Zhao Zhihe2,Liao Wen2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China;
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
  • Received:2018-11-10 Revised:2019-04-02 Online:2019-07-01 Published:2019-07-12
  • Supported by:
    This study was supported by National Natural Science Foundation of China(31600752);Undergraduate Student Innovation and Entrepreneurship Training Program of Sichuan University(C2018103847);Sichuan University-Luzhou Municipal Government Strategic Cooperation Project(2018CDLZ-14)

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Abstract:

Tea polyphenols are a general term for polyphenols in tea, and epigallocatechin-3-gallate (EGCG) is a major component. As an antioxidant, EGCG can participate in the regulation of various life processes, including anti-inflammatory and anti-tumour activities. Epidemiological investigations and animal experiments have confirmed that EGCG can inhibit periodontitis and subsequent bone loss. Therefore, it might be a potential adjuvant treatment for periodontal treatment. Due to its anti-inflammatory and osteogenic functions, EGCG also has great potential in the modification of tissue engineering materials for bone defect repair. This article reviews the mechanism by which EGCG participates in stem cell proliferation and osteogenic differentiation, and summarises its advantages as a tissue engineering material. This paper provides a theoretical basis for the use of EGCG as periodontitis adjuvant therapy and bone tissue engineering material.

Key words: epigallocatechin-3-gallate, proliferation, osteogenesis, tissue engineering

CLC Number: 

  • Q254

TrendMD: 

Fig 1

The structure of EGCG"

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