Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (4): 387-389.doi: 10.7518/gjkq.2014.04.004

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Histological changes of the parotid gland following release from duct ligation

Mao Yulong1, Zhang Weiwei2, Zuo Jinhua1   

  1. 1. Dept. of Oral and Maxillofacial Surgery, The Affiliated Hospital of Binzhou Medical College, Binzhou 256603, China; 2. Dept. of Orthodontics, The Affiliated Hospital of Binzhou Medical College, Binzhou 256603, China
  • Received:2013-10-29 Revised:2014-01-29 Online:2014-07-01 Published:2014-07-01

Abstract:

Objective The histological changes of the parotid gland were investigated following release from duct ligation. Methods The right parotid ducts of Wistar rats were ligated for 7 days and then reopened. The specimens were harvested at days 0, 1, 3, 5, 7, 14, and 21. The histological changes of the gland were investigated by hematoxylineosin( HE) staining and morphology measurement. Results The parotid gland atrophied significantly after duct ligation for 7 days. From day 1 after duct reopening, the acinar volume fraction continued to increase significantly; both the duct and mesenchymal volume fraction continued to decrease significantly(P<0.05). After 14 days of regeneration, no significant differences in the volume fractions of acinas, ducts, and mesenchyma were observed compared with the normal control group(P>0.05). Conclusion The atrophied parotid gland regenerated to normal after 7 days of duct ligation.

Key words: parotid gland, duct ligation, atrophy, regeneration, morphometry

CLC Number: 

  • R 781.7

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