Int J Stomatol

Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (6): 707-711.doi: 10.7518/gjkq.2014.06.022

Previous Articles     Next Articles

Research progress on dental pulp stem cells differentiation into vascular endothelial cells

Liu Wei, Ling Junqi   

  1. Dept. of Conservative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Online:2014-11-01 Published:2014-11-01

RichHTML

4

PDF (PC)

2003

Abstract:

Vascular endothelial cells are the core of the vessels. These cells express some specific markers, such as vascular endothelial growth factor receptor2, CD31, and the von Willebrand factor. These cells can promote the formation of tube structures in matrigel. Dental pulp stem cells has potential for self-renewal and differentiation into a variety of cell types, including osteoblast-like cells, chondrocytes, adipocytes, and neural-like cells in different medium with various content of inducer. Dental pulp stem cells also express endothelial cell markers and form vascular-like structure in vitro when cultured in low-serum culture medium added with vascular endothelial growth factor and fibroblast growth factor. In vivo studies suggest that these cells can promote angiogenesis and blood perfusion of regional ischemic tissue, which further confirms that dental pulp stem cells can also be differentiated into endothelial cells.

Key words: dental pulp stem cell, vascular endothelial cell, differentiation


TrendMD: 
[1] Abulaiti Guliqihere,Qin Xu,Zhu Guangxun. Research progress of mitophagy in the onset and development of periodontal disease [J]. Int J Stomatol, 2024, 51(1): 68-73.
[2] Yu Lerong,Li Xiangwei,Ai Hong. Research progress on the stemness maintenance of dental pulp stem cells [J]. Int J Stomatol, 2023, 50(4): 463-471.
[3] Liu Tiqian,Liang Xing,Liu Weiqing,Li Xiaohong,Zhu Rui.. Research progress on the role and mechanism of occlusal trauma in the development of periodontitis [J]. Int J Stomatol, 2023, 50(1): 19-24.
[4] Zhang Jingyi,Li Danwei,Sun Yu,Lei Yayan,Liu Tao,Gong Yu. In vitro cytotoxicity of composite resin and compomer and effect on osteogenic differentiation of osteoblasts [J]. Int J Stomatol, 2022, 49(4): 412-419.
[5] Hong Yaya,Chen Xuepeng,Si Misi. Advances in research on noncoding RNA during the osteogenic differentiation of dental follicle stem cells [J]. Int J Stomatol, 2022, 49(3): 263-271.
[6] Fu Hengyi,Wang Chenglin. Research progress on serum-free culture methods of human dental pulp stem cells and cell characterization [J]. Int J Stomatol, 2022, 49(2): 220-226.
[7] Xiong Menglin,Wu Long,Ma Li,Zhao Jin. Role of transforming growth factor-β2 in promoting the proliferation and differentiation of dental pulp stem cells [J]. Int J Stomatol, 2021, 48(6): 635-639.
[8] Guo Yuting,Lü Xuechao. Research progress on drugs regulating the osteogenic differentiation of dental pulp stem cells [J]. Int J Stomatol, 2021, 48(6): 737-744.
[9] Liu Juan,Chen Bin,Yan Fuhua. Effects of platelet-rich plasma and concentrated growth factor on the proliferation and osteogenic differentiation of human periodontal cells [J]. Int J Stomatol, 2021, 48(5): 520-527.
[10] Lei Shuang,Yu Jingjun,Tang Xiaolin. Research progress on the effects and mechanisms of Porphyromonas gingivalis on vascular endothelial cells from different tissues [J]. Int J Stomatol, 2021, 48(1): 23-28.
[11] Li Jingya,Shui Yusen,Guo Yongwen. Advances in mechanisms for osteogenic differentiation of human periodontal ligament cells induced by cyclic tensile stress [J]. Int J Stomatol, 2020, 47(6): 652-660.
[12] Yang Yeqing,Chen Ming,Wu Buling. Research progress on circular RNA in the osteogenic differentiation of mesenchymal stem cells [J]. Int J Stomatol, 2020, 47(3): 257-262.
[13] Liu Junqi,Chen Yiyin,Yang Wenbin. Research progress on N6-methyladenosine for regulating the osteogenic differentiation of bone marrow mesenchymal stem cells [J]. Int J Stomatol, 2020, 47(3): 263-269.
[14] Zhu Mingjing,Zhang Qingbin. Comparative review of growth factors inducing 3D in vitro cartilage formation of mesenchymal stem cells [J]. Int J Stomatol, 2020, 47(3): 270-277.
[15] Wang Runting,Fang Fuchun. Progress in research of non-coding RNAs in osteogenic differentiation of human periodontal ligament stem cells [J]. Int J Stomatol, 2020, 47(2): 138-145.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 2004, 31(02): 126 -128 .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .