Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (3): 344-346.doi: 10.7518/gjkq.2013.03.019

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Effect of Nel-like type 1 growth factor in craniomaxillofacial bone tissue engineering

Chen Mu1，2, Huang Hongzhang2   

  1. 1. Dept. of Stomatology, The Affiliated Nanshan Hospital of Guangdong Medical College, Shenzhen 518052, China；2. Dept. of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China
  • Received:2012-04-28 Revised:2012-07-20 Online:2013-05-01 Published:2013-05-01

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Abstract:

There are often various causes of bone defects in clinics. A new approach has been put forward in recent years to settle the problem, which is bone tissue engineering. Novel osteospecific growth factors are very important to the bone tissue engineering, because of the efforts to enhance bone regeneration. Nel-like type 1（NELL-1）growth factor, a potent growth factor associated with craniosynostosis, is highly specific to the osteochondral lineage, and has demonstrated induction of bone in multiple in various models. And unlike bone morphogenetic protein-2, NELL-1 growth factor cannot initiate ectopic bone formation in muscle. This review summarized the studies on NELL-1 growth factor that had relevance to bone tissue engineering, especially in craniomaxillofacial filed.

Key words: Nel-like type 1 growth factor, craniomaxillofacial, tissue engineering


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