Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (2): 148-151.doi: 10.7518/gjkq.2013.02.003

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The expression of human β-defensin-2 in salivary gland of Sjogren syndrome

Wang Tian, Tao Renchuan   

  1. 1. Dept. of Conservative Dentistry and Endodontics, Tianjin Stomatological Hospital, Tianjin 300041, China; 2. Dept. of Mucosa Disease, The Affiliated Stomatological Hospital of Guangxi Medical University, Nanning 530021, China
  • Received:2012-09-13 Revised:2012-11-30 Online:2013-03-01 Published:2013-03-01
  • Contact: Wang Tian, Tel： 022-27119191

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Abstract:

Objective To explore the expressions of human β-defensin（hBD）-2 and hBD-2 mRNA in salivary glands of patients with Sj觟gren syndrome（SS） and to explain the correlation between hBD-2 and clinical, clinicopathologic features. Methods To detect the expression of hBD-2 by streptaividin perodaxe immunohostochemical and in situ hybridization method from 30 cases suffered from SS and 10 cases from normal salivary glands. Correlations between hBD-2 and Chisholm’s score or organic manifestations were investigated. Results hBD-2 was observed in salivary glands from patients with SS, but few hBD-2 positive cells could be seen in salivary glands in the normal specimens. The high score of Chisholm’s score and SS with other organic manifestations were also correlated with a higer percentage of hBD-2 of SS patients. Conclusion hBD-2 was overexpressed in glands’ ductal epithelial cells in SS and related with the chronic inflammation campared with normal specimens and may play an important role in the local autoimmune reaction

Key words: Sjogren syndrome, salivary gland, human β-defensin-2, immunohistochemistry, in situ hybridization


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