Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (6): 625-628.doi: 10.3969/j.issn.1673-5749.2010.06.002

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Repair of mandible defect with kalium and strontium-doped calcium polyphosphate

XIE Hui-xu1, WANG Ping1, WANG Qian-bin2, CHENG Shi-bing1, WAN Chang-xiu2, LI Long-jiang1.   

  1. 1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China; 2. College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China
  • Received:2010-05-14 Revised:2010-08-24 Online:2010-11-20 Published:2010-11-20

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Abstract:

Objective To study the effects of kalium and strontium-doped calcium polyphosphate on the repair of mandibular defects of rabbit. Methods Prepare kalium and strontium-doped calcium polyphosphate（KSCPP） and hydroxyapatite（HA）. Bone defects of 15 mm×4 mm×2 mm were made at middle part of bottom edge of 12 rabbit mandibles. KSCPP or HA was applied to the right side, while the left side was sutured without implant of materials. After 4, 8, 12 weeks implantation, the effectiveness of bone formation was evaluated by means of X-ray observation and histological examination. Results KSCPP was not rejected by hosts. After 12 weeks, KSCPP was partially degraded, newly regenerated bone grew into and merged with the material. The capacity of bone regeneration was stronger than HA. Conclusion KSCPP has a good biocompatibility, osteoconductivity, osteoinductivity, and biodegradation. It may be a promising bone repair alternative.

Key words: calcium polyphosphate, co-substituted, bone defect, repair


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