Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (02): 178-178～181,185.doi: 10.3969/j.issn.1673-5749.2010.02.015

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Research progress of oral cancer-associated fibroblast

ZHENG Xiao-bin, CHEN Zuo-liang   

  1. Dept. of Oral Medicine, Xiamen Stomatological Hospital, Teaching Hospital of Stom
  • Received:2009-06-04 Revised:2009-11-26 Online:2010-03-20 Published:2010-03-20
  • Contact: CHEN Zuo-liang

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Abstract: Tumor-host interface microenvironment is composed of mesenchymal cells and extra cellular matrix components, which plays an important role in the growth, invasion and metastasis of tumor cells. The most important cell component in this environment is the cancer-associated fibroblast（CAF）, which plays an important role in oral cancer development, and the tumor mesenchymal therapy which aims to CAF exploit a new path of tumor prevention and treatment. This article is an overview about CAF and its original, researching its relation with oral cancer and therapy.

Key words: cancer-associated fibroblast, oral cancer, therapy

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