国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (5): 644-654.doi: 10.7518/gjkq.2025093

• 综述 • 上一篇    下一篇

原花青素对口腔疾病调控机制和防治的研究进展

伍行1,2(),刘玉平1,张伊钒1,夏郁葱1,李照禾1,易小炜1,夏鸿1(),丁文文1   

  1. 1.荆楚理工学院医学部 荆门 448001
    2.浙江中医药大学口腔医学院 杭州 310059
  • 收稿日期:2024-09-06 修回日期:2024-10-31 出版日期:2025-09-01 发布日期:2025-08-27
  • 通讯作者: 夏鸿
  • 作者简介:伍行，硕士，Email：wuxing2062@163.com
  • 基金资助:
    湖北省教育厅科学研究计划(D20224301);特色花卉生物育种湖北省工程研究中心开放课题(2023YB003);湖北省大学生创新创业项目(S202311336023);湖北省大学生创新创业项目(S202511336046)

Research progress on the regulatory mechanism and prevention and treatment of proanthocyanidins in oral diseases

Xing Wu1,2(),Yuping Liu1,Yifan Zhang1,Yucong Xia1,Zhaohe Li1,Xiaowei Yi1,Hong Xia1(),Wenwen Ding1   

  1. 1.Dept. of Medicine, Jingchu University of Technology, Jingmen 448001, China
    2.School of Stomatology, Zhejiang Chinese Medicine University, Hangzhou 310059, China
  • Received:2024-09-06 Revised:2024-10-31 Online:2025-09-01 Published:2025-08-27
  • Contact: Hong Xia
  • Supported by:
    Science Research Program of the Education Department of Hubei Province(D20224301);Open Project of Hubei Engineering Research Center for Special Flower Biological Breeding(2023YB003);Innovation and Entrepreneurship Program for College Students of Hubei Province(S202311336023)

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摘要：

原花青素（PC）是一类具有强大抗氧化和多重生物活性的天然化合物，在口腔疾病预防和治疗中展现出巨大的应用潜力。PC能有效促进牙体组织再矿化，干预牙菌斑生物膜形成，抑制口腔癌细胞增殖，并在口腔黏膜疾病的治疗中显示出积极效果。本综述通过深入分析，总结认为：PC防治口腔疾病的核心优势在于其双重作用机制，既能靶向抑制病原生物膜，又能调节宿主的氧化应激与炎症反应；尤为重要的是，PC通过非杀菌途径干预微生物黏附与生物膜形成，有望为克服菌株耐药问题提供新策略。尽管多数研究目前仍处于实验室阶段，但PC的安全性和多效性使其成为口腔疾病治疗中极有前景的天然辅助剂。本文旨在通过系统总结PC在多种口腔常见病中的应用，并揭示其生物学作用和机制，以期为临床转化应用提供参考。

关键词: 原花青素, 口腔疾病, 免疫调节, 疾病防治

Abstract:

Proanthocyanidins (PCs), a class of natural compounds with strong antioxidant properties and diverse biolo-gical activities, demonstrate significant potential in the prevention and treatment of oral diseases. They effectively promote the remineralization of dental hard tissues, inhibit the development of dental plaque biofilms, suppress the proliferation of oral cancer cells, and provide beneficial effects in the treatment of oral mucosal diseases. This review highlights that the core advantage of PCs in managing oral diseases stems from their dual-action mechanism: they not only target and inhibit pathogenic biofilms but also modulate the host’s oxidative stress and inflammatory responses. Notably, PCs interfere with microbial adhesion and biofilm formation via a non-bactericidal pathway, offering a novel strategy to potentially address microbial drug resistance. Although most current research is confined to the laboratory stage, the safety and multipotency of PCs position them as a promising natural adjuvant for oral disease therapy. This review systema-tically summarizes the applications of PCs in prevalent oral diseases and elucidates their biological mechanisms, aiming to establish a scientific basis for future clinical translation.

Key words: procyanidins, oral diseases, immune regulation, prevention and treatment of diseases

中图分类号: 

  • R78

图1

A型PC（左）与B型PC（右）的化学结构"

图2

PC的生物活性对口腔常见疾病的作用"

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