国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (5): 655-661.doi: 10.7518/gjkq.2025084

• 综述 • 上一篇    下一篇

牙源性间充质干细胞来源细胞外囊泡的免疫调节作用

王博群(),陆慧,穆晴,赵玮()   

  1. 中山大学光华口腔医学院·附属口腔医院儿童口腔科广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2024-07-11 修回日期:2025-06-29 出版日期:2025-09-01 发布日期:2025-08-27
  • 通讯作者: 赵玮
  • 作者简介:王博群，学士，Email：wangbq9@mail2.sysu.edu.cn
  • 基金资助:
    广东省自然科学基金(2023A1515012554);中山大学大学生创新创业计划(20240491)

Immune regulation mediated by extracellular vesicles from dental-derived mesenchymal stem cells

Boqun Wang(),Hui Lu,Qing Mu,Wei Zhao()   

  1. Dept. of Pediatric Dentistry, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2024-07-11 Revised:2025-06-29 Online:2025-09-01 Published:2025-08-27
  • Contact: Wei Zhao
  • Supported by:
    Natural Science Foundation of Guangdong Province(2023A1515012554);Student Innovation and Entrepreneurship Training Program of Sun Yat-sen University(20240491)

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摘要：

干细胞产生的细胞外囊泡（EV）可携带多种具有生物活性的物质，是细胞间进行信息交流的重要介质。相较于其他组织来源的干细胞，牙源性间充质干细胞（DMSC）有着诸多独特的优势，其分泌的EV能够通过调控免疫细胞的活性及局部组织细胞的炎症水平，在创伤、感染等因素导致的疾病中起到免疫调节的作用，可应用于组织修复与再生医学领域。本文拟从免疫调节的角度出发，对DMSC来源的EV在口腔及其他疾病中的调节作用展开综述。

关键词: 细胞外囊泡, 牙源性间充质干细胞, 免疫调节

Abstract:

Extracellular vesicles (EVs) released by stem cells carry various bioactive molecules that are essential for mediating intercellular communication. Compared with other tissues-derived stem cells, mesenchymal stem cells derived from dental tissues possess several unique advantages, including accessibility, proliferative capacity, and immunomodulatory potential. EVs secreted by these mesenchymal stem cells have been shown to influence immune cell function and modulate inflammatory responses within local cellular and tissue environments. These immunoregulatory properties are particularly relevant in the context of inflammation-related diseases resulting from trauma, infection, and other pathological stimuli, highlighting the potential of these EVs in tissue repair and regenerative medicine. This review focuses on the immunomodulatory roles of EVs from mesenchymal stem cells derived from dental tissues and their regulatory functions in oral and systemic inflammatory diseases.

Key words: extracellular vesicle, dental-derived mesenchymal stem cell, immune regulation

中图分类号: 

  • Q254
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