国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (2): 172-176.doi: 10.7518/gjkq.2016.02.013
丁烨1,任静宜1,于洪强1,周延民1,于维先2
Ding Ye1, Ren Jingyi1, Yu Hongqiang1, Zhou Yanmin1, Yu Weixian2
摘要: 病原相关分子模式(PAMP)和损伤相关分子模式(DAMP)是与免疫学息息相关的两个分子。DAMP是组织或细胞受到损伤和低氧等因素刺激后释放到细胞间或血液循环中的一类物质;PAMP则是病原体上的分子结构。两者均被模式识别受体(PRR)识别引起免疫应答。目前,已经有研究表明,DAMP和PAMP与慢性炎症疾病和自身免疫性疾病有关。本文就PAMP和DAMP分子在免疫炎症反应中的作用作一综述。
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