国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (4): 476-482.doi: 10.7518/gjkq.2022067

• 综述 • 上一篇    下一篇

介孔硅酸钙纳米材料在牙体牙髓及颅颌面修复领域的研究进展

张曦丹(),孙吉宇,付馨靓,甘雪琦()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院修复科 成都 610041
  • 收稿日期:2021-10-02 修回日期:2022-03-08 出版日期:2022-07-01 发布日期:2022-06-28
  • 通讯作者: 甘雪琦
  • 作者简介:张曦丹，硕士，Email：2020224035068@scu.edu.cn
  • 基金资助:
    国家自然科学基金(81870802)

Research progress on the development of mesoporous calcium silicate nanoparticles in endodontics and repairing maxillofacial bone defects

Zhang Xidan(),Sun Jiyu,Fu Xinliang,Gan Xueqi.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-10-02 Revised:2022-03-08 Online:2022-07-01 Published:2022-06-28
  • Contact: Xueqi. Gan
  • Supported by:
    National Natural Science Foundation of China(81870802)

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摘要：

介孔硅酸钙纳米材料（MCSN）是近年来基于传统硅酸钙生物活性材料研发出的新型生物活性材料，具有良好的介孔结构和纳米级粒子直径，具备优秀的生物相容性、生物活性、抗菌性、载药缓释性等生物学性能，还可以通过功能化金属元素修饰对其进行改性，在口腔医学领域具有极大的潜力。MCSN对常见的口腔致病菌具有良好的抗菌性，可以渗入到牙本质小管中，促进牙体硬组织再矿化，在牙体牙髓领域具有广阔的应用前景；此外，MCSN相关的复合支架材料具有良好的成骨活性和改性潜能，在颅颌面修复领域具有广大的应用潜力。本文对MCSN的生物学性能以及在牙体牙髓及颅颌面修复领域的研究进展进行综述，并为未来研究方向提供参考及依据。

关键词: 介孔硅酸钙纳米材料, 生物相容性, 生物活性, 抗菌, 载药, 生物学性能, 牙体牙髓, 颅颌面修复

Abstract:

Mesoporous calcium silicate nanoparticles (MCSNs), a novel bioactive material with a nanoscale size and an ordered mesoporous channel structure, possess excellent biocompatibility, bioactivity, antibacterial properties, and drug delivery characteristics. Besides, they can be modified by metal elements and improve the properties of biocomposites. Therefore, the development of MCSNs is currently a research focus in stomatology. MCSNs have antibacterial activity against a range of common oral pathogens. Moreover, they can cover the root canal wall, infiltrate the dentinal tubules, and induce cementum tissue regeneration; therefore, they have a potential in the endodontics field. Furthermore, MCSN scaffold showed excellent ability in osteogenesis and modification and thus could be potentially applied in oral and maxillofacial surgeries. This article reviews the biological properties and research progress of MCSNs in endodontics and their application in the repair of maxillofacial bone defects and provides preliminary experimental basis for further research on MCSNs.

Key words: mesoporous calcium-silicate nanoparticle, biocompatibility, bioactivity, antibacterial property, drug delivery property, biological property, endodontics, maxillofacial bone defect

中图分类号: 

  • R 318.08
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