国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (4): 471-477.doi: 10.7518/gjkq.2020044

• 综述 • 上一篇    下一篇

药物辅助治疗种植体周围炎的研究进展

吴秋月1,李治邦2()   

  1. 1.中国人民解放军第32308部队门诊部口腔科 张家口 075000
    2.中国人民解放军第66081部队卫生队口腔科 张家口 075400
  • 收稿日期:2019-10-29 修回日期:2020-03-27 出版日期:2020-07-01 发布日期:2020-07-10
  • 通讯作者: 李治邦
  • 作者简介:吴秋月,医师,学士,Email：395026830@qq.com

Research progress on the adjunctive drug therapy of peri-implantitis

Wu Qiuyue1,Li Zhibang2()   

  1. 1. Dept. of Stomatology, Outpatient Department of 32308 Troop, Zhangjiakou 075000, China
    2. Dept. of Stomatology, Medical Team of 66081 Troop, Zhangjiakou 075400, China
  • Received:2019-10-29 Revised:2020-03-27 Online:2020-07-01 Published:2020-07-10
  • Contact: Zhibang Li

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摘要：

随着口腔种植的广泛应用,临床上患有种植体周围炎的患者也越来越多。种植体周围炎是导致种植失败的重要原因。种植体周围炎的治疗方法可分为非手术治疗和手术治疗2种。药物治疗作为一种非手术治疗方式,主要用于辅助其他治疗方式,增强治疗效果。相对于天然牙的牙周炎,种植体周围炎的治疗更为困难,药物的辅助作用也更为重要。临床上用于辅助治疗种植体周围炎的药物种类繁多且疗效存在争议。本文就种植体周围炎治疗中常用药物的研究进展进行综述,以便于临床上合理用药,并为进一步的研究提供思路。

关键词: 种植体周围炎, 药物治疗, 抗菌剂, 抗生素

Abstract:

Many patients suffer from peri-implantitis due to the extensive application of implants in dental practice. The treatment of peri-implantitis can be categorized into non-surgical and surgical treatments. Drug therapy is a non-surgical treatment mostly applied with other techniques to enhance their therapeutic effects. The treatment of peri-implantitis is more difficult than that of periodontitis of natural teeth, and adjuvant drug treatment is highly important. At present, the drug protocols for peri-implantitis treatment vary, and the efficacy is controversial. This paper reviews the research progress on commonly used drugs in clinical practice to facilitate rational drug use and provide ideas for further research.

Key words: peri-implantitis, drug treatment, antimicrobial, antibiotics

中图分类号: 

  • R783.4
[1] Salvi GE, Cosgarea R, Sculean A. Prevalence and mechanisms of peri-implant diseases[J]. J Dent Res, 2017,96(1):31-37.
doi: 10.1177/0022034516667484 pmid: 27680028
[2] Rakic M, Galindo-Moreno P, Monje A, et al. How frequent does peri-implantitis occur? A systematic review and meta-analysis[J]. Clin Oral Investig, 2018,22(4):1805-1816.
pmid: 29218422
[3] 马翔, 柳忠豪. 3 557例种植患者种植体周围炎的回顾性研究[J]. 实用口腔医学杂志, 2018,34(5):665-669.
Ma X, Liu ZH. Peri-implantitis: a retrospective study of 3 557 patients[J]. J Pract Stomatol, 2018,34(5):665-669.
[4] Renvert S, Polyzois I. Treatment of pathologic peri-implant pockets[J]. Periodontol 2000, 2018,76(1):180-190.
pmid: 29239086
[5] de Almeida JM, Matheus HR, Rodrigues Gusman DJ, et al. Effectiveness of mechanical debridement combined with adjunctive therapies for nonsurgical treatment of periimplantitis: a systematic review[J]. Implant Dent, 2017,26(1):137-144.
pmid: 27548110
[6] Lang NP, Salvi GE, Sculean A. Nonsurgical therapy for teeth and implants—when and why[J]. Periodon-tol 2000, 2019,79(1):15-21.
[7] Mombelli A. Maintenance therapy for teeth and im-plants[J]. Periodontol 2000, 2019,79(1):190-199.
[8] Bernardi A, Teixeira CS. The properties of chlorhexi-dine and undesired effects of its use in endodontics[J]. Quintessence Int, 2015,46(7):575-582.
doi: 10.3290/j.qi.a33934 pmid: 25918757
[9] Figuero E, Graziani F, Sanz I, et al. Management of peri-implant mucositis and peri-implantitis[J]. Perio-dontol 2000, 2014,66(1):255-273.
[10] Lee BS, Shih KS, Lai CH, et al. Surface property alterations and osteoblast attachment to contaminated titanium surfaces after different surface treatments: an in vitro study[J]. Clin Implant Dent Relat Res, 2018,20(4):583-591.
[11] Carcuac O, Derks J, Charalampakis G, et al. Adjun-ctive systemic and local antimicrobial therapy in the surgical treatment of peri-implantitis: a randomized controlled clinical trial[J]. J Dent Res, 2016,95(1):50-57.
doi: 10.1177/0022034515601961 pmid: 26285807
[12] Carral C, Muñoz F, Permuy M, et al. Mechanical and chemical implant decontamination in surgical peri-implantitis treatment: preclinical “in vivo” study[J]. J Clin Periodontol, 2016,43(8):694-701.
doi: 10.1111/jcpe.12566 pmid: 27105820
[13] Heo S, Kim HJ, Joo JY, et al. Simplified nonsurgical treatment of peri-implantitis using chlorhexidine and minocycline hydrochloride[J]. J Periodontal Implant Sci, 2018,48(5):326-333.
[14] Wiedmer D, Petersen FC, Lönn-Stensrud J, et al. An-tibacterial effect of hydrogen peroxide-titanium dioxide suspensions in the decontamination of rough titanium surfaces[J]. Biofouling, 2017,33(6):451-459.
pmid: 28524724
[15] Kotsakis GA, Lan CX, Barbosa J, et al. Antimicro-bial agents used in the treatment of peri-implantitis alter the physicochemistry and cytocompatibility of titanium surfaces[J]. J Periodontol, 2016,87(7):809-819.
doi: 10.1902/jop.2016.150684 pmid: 26923474
[16] Saffarpour A, Nozari A, Fekrazad R, et al. Micros-tructural evaluation of contaminated implant surface treated by laser, photodynamic therapy, and chlor-hexidine 2 percent[J]. Int J Oral Maxillofac Implants, 2018,33(5):1019-1026.
pmid: 30231087
[17] Stewart B, Shibli JA, Araujo M, et al. Effects of a toothpaste containing 0.3% triclosan in the main-tenance phase of peri-implantitis treatment: 2-year randomized clinical trial[J]. Clin Oral Implants Res, 2018,29(10):973-985.
doi: 10.1111/clr.13363 pmid: 30328176
[18] Kanwar I, Sah AK, Suresh PK. Biofilm-mediated antibiotic-resistant oral bacterial infections: mechanism and combat strategies[J]. Curr Pharm Des, 2017,23(14):2084-2095.
pmid: 27890003
[19] Reddy R, Palaparthy R, Durvasula S, et al. Gingivitis and plaque prevention using three commercially available dentifrices: a comparative clinical and microbiological randomized control parallel study[J]. Int J Pharm Investig, 2017,7(3):111-118.
[20] Levin L, Barbu H, Kurgan S, et al. Evaluation of 0.2% delmopinol mouth rinse for prevention of peri-implant mucositis and peri-implantitis: a randomized controlled canine study[J]. Clin Implant Dent Relat Res, 2019,21(1):46-51.
[21] Luis HS, Luis LS, Bernardo M. In vitro study of the effect of an essential oil and a delmopinol mouth rinse on dental plaque bacteria[J]. Indian J Dent Res, 2016,27(6):648-651.
pmid: 28169264
[22] 刘欧, 高祝, 李涛, 等. 盐酸米诺环素软膏治疗种植体周围炎的可行性[J]. 中国组织工程研究, 2018,22(6):852-857.
Liu O, Gao Z, Li T, et al. Minocycline hydrochloride ointment is available for the treatment of peri-im-plantitis[J]. Chin J Tissue Eng Res, 2018,22(6):852-857.
[23] Ramos UD, Suaid FA, Wikesjö UME, et al. Com-parison between two antimicrobial protocols with or without guided bone regeneration in the treatment of peri-implantitis. A histomorphometric study in dogs[J]. Clin Oral Implants Res, 2017,28(11):1388-1395.
pmid: 28054383
[24] Lee JB, Kweon HH, Cho HJ, et al. Characteristics of local delivery agents for treating peri-implantitis on dental implant surfaces: a preclinical study[J]. J Oral Implantol, 2019,45(2):116-126.
pmid: 30452331
[25] Cha JK, Lee JS, Kim CS. Surgical therapy of peri-implantitis with local minocycline: a 6-month rando-mized controlled clinical trial[J]. J Dent Res, 2019,98(3):288-295.
pmid: 30626263
[26] Koukos G, Papadopoulos C, Tsalikis L, et al. Pre-valence of antibiotic resistance genes in subjects with successful and failing dental implants. A pilot study[J]. Open Dent J, 2014,8:257-263.
doi: 10.2174/1874210601408010257 pmid: 25646133
[27] Rams TE, Degener JE, van Winkelhoff AJ. Antibiotic resistance in human peri-implantitis microbiota[J]. Clin Oral Implants Res, 2014,25(1):82-90.
doi: 10.1111/clr.12160 pmid: 23551701
[28] Nastri L, De Rosa A, De Gregorio V, et al. A new controlled-release material containing metronidazole and doxycycline for the treatment of periodontal and peri-implant diseases: formulation and in vitro tes-ting[J]. Int J Dent, 2019,2019:9374607.
doi: 10.1155/2019/9374607 pmid: 30956660
[29] Nart J, de Tapia B, Pujol À, et al. Vancomycin and tobramycin impregnated mineralized allograft for the surgical regenerative treatment of peri-implantitis: a 1-year follow-up case series[J]. Clin Oral Investig, 2018,22(6):2199-2207.
doi: 10.1007/s00784-017-2310-0 pmid: 29275491
[30] Galofré M, Palao D, Vicario M, et al. Clinical and microbiological evaluation of the effect of Lacto-bacillus reuteri in the treatment of mucositis and peri-implantitis: a triple-blind randomized clinical trial[J]. J Periodont Res, 2018,53(3):378-390.
doi: 10.1111/jre.12523 pmid: 29352461
[31] 林毅, 陈詹宏, 陈玉英. 地塞米松喷雾剂联合牙髓干细胞治疗糖尿病Beagle犬种植体周围炎的实验研究[J]. 中国临床药理学杂志, 2017,33(23):2398-2400.
Lin Y, Chen ZH, Chen YY. Experimental study of dexamethasone spray combined with dental pulp stem cells in the treatment of peri-implantitis of dia-betic mellitus Beagle dogs[J]. Chin J Clin Pharmacol, 2017,33(23):2398-2400.
[32] Papathanasiou E, Finkelman M, Hanley J, et al. Prevalence, etiology and treatment of peri-implant mucositis and peri-implantitis: a survey of perio-dontists in the United States[J]. J Periodontol, 2016,87(5):493-501.
doi: 10.1902/jop.2015.150476 pmid: 26643222
[33] Ong A, Kim J, Loo S, et al. Prescribing trends of systemic antibiotics by periodontists in Australia[J]. J Periodontol, 2019,90(9):982-992.
doi: 10.1002/JPER.18-0586 pmid: 30825215
[34] Hallström H, Persson GR, Lindgren S, et al. Open flap debridement of peri-implantitis with or without adjunctive systemic antibiotics: a randomized clinical trial[J]. J Clin Periodontol, 2017,44(12):1285-1293.
doi: 10.1111/jcpe.12805 pmid: 28836279
[35] Carcuac O, Derks J, Abrahamsson I, et al. Surgical treatment of peri-implantitis: 3-year results from a randomized controlled clinical trial[J]. J Clin Perio-dontol, 2017,44(12):1294-1303.
[36] Verdugo F, Laksmana T, Uribarri A. Systemic anti-biotics and the risk of superinfection in peri-im-plantitis[J]. Arch Oral Biol, 2016,64:39-50.
doi: 10.1016/j.archoralbio.2015.12.007 pmid: 26761363
[37] 陈飞, 焦鹏, 车鸿泽, 等. 中药双黄补联合西帕依固龈液对种植体周围炎患者牙周炎症的改善作用及其临床意义[J]. 吉林大学学报(医学版), 2017,43(6):1226-1230.
Chen F, Jiao P, Che HZ, et al. Improvement effect of Shuanghuangbu combined with Xipayi Mouth Rinse on periodontal inflammation of peri-implantitis pa-tients and its clinical significance[J]. J Jilin Univ (Med Ed), 2017,43(6):1226-1230.
[38] 黄涛, 刘琳. 黄连上清软胶囊辅助治疗种植体周围炎的临床观察[J]. 中国药房, 2016,27(18):2491-2493.
Huang T, Liu L. Clinical observation of Huanglian Shangqing soft capsule in the adjuvant treatment of inflammation around implant[J]. China Pharm, 2016,27(18):2491-2493.
[39] Wang J, Wang L, Lou GH, et al. Coptidis rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology[J]. Pharm Biol, 2019,57(1):193-225.
[40] Zhang R, Yang J, Wu J, et al. Berberine promotes osteogenic differentiation of mesenchymal stem cells with therapeutic potential in periodontal regenera-tion[J]. Eur J Pharmacol, 2019,851:144-150.
pmid: 30776366
[41] 王冰杰, 杨超, 古再丽努尔·依不拉音, 等. 维药买朱尼治疗种植体周围炎前后牙周情况的变化[J]. 临床口腔医学杂志, 2018,34(2):85-88.
Wang BJ, Yang C, Gulizainuer·Yibulayin, et al. The change of periodontal conditions before and after Maizhuni treatment peri-implantitis[J]. J Clin Sto-matol, 2018,34(2):85-88.
[42] 古丽再努·依不拉音, 吐逊阿依·阿迪力, 任家卉, 等. 维药买朱尼对种植体周围炎龈沟液中白细胞介素-1β和牙周指数的影响[J]. 口腔医学研究, 2017,33(7):762-765.
Gulizainv·Yibula Y, Tuxuna Y·Adili, Ren JH, et al. Effect of Uygur medicine Maizhuni on IL-1β in crevicular fluid and periodontal index in peri-im-plantitis[J]. J Oral Sci Res, 2017,33(7):762-765.
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[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
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