国际口腔医学杂志

国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (3): 334-340.doi: 10.7518/gjkq.2021021

• 综述 • 上一篇    下一篇

钛种植体表面银纳米颗粒负载方法的进展

朱俊瑾(),王剑   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院修复科 成都 610041
  • 收稿日期:2020-08-09 修回日期:2020-12-15 出版日期:2021-05-01 发布日期:2021-05-14
  • 作者简介:朱俊瑾,学士,Email： 512391940@qq.com
  • 基金资助:
    国家自然科学基金(81970985)

Advances in the loading methods of silver nanoparticles on the surface of titanium implants

Zhu Junjin(),Wang Jian.   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodon-tics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-08-09 Revised:2020-12-15 Online:2021-05-01 Published:2021-05-14
  • Supported by:
    National Natural Science Foundation of China(81970985)

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摘要：

钛种植体是口腔种植修复的常用种植体,但它本身无抗菌活性,临床若发生细菌感染,可能会引起种植体周围炎,导致种植治疗失败。银纳米颗粒（Ag NP）作为一种抗菌谱广、低耐药性的抗菌剂,常用以构建钛种植体上抗菌表面涂层,从而增强钛种植体的抗菌性。近10年来,研究人员关于钛基表面稳定负载Ag NP方面进行了大量研究,通过调整掺银方法或添加其他物质,进一步提高钛种植体的抗菌活性,同时避免Ag NP的细胞毒性。本文综述了目前在钛种植体上负载Ag NP的方法及其优缺点,并且对如何优化Ag NP的负载量和降低细胞毒性方面进行了方法总结,以期为相关领域研究提供参考。

关键词: 钛种植体, 银纳米颗粒, 负载方法, 抗菌性能, 细胞毒性

Abstract:

Titanium dental implants are commonly used in oral implant repair. However, because they lack intrinsic antibacterial activity, these implants may lead to peri-implantitis and even implant surgery failure when bacterial infection occurs. Silver nanoparticles (Ag NPs), which are antibacterial agents with a wide antibacterial spectrum and low resistance, are commonly used to build antibacterial coatings on titanium implants and amplify their antimicrobial properties. Over the last decade, researchers have conducted numerous studies on the integration of Ag NPs into titanium implants to improve the antibacterial properties of the latter and avoid the cytotoxicity of the former by adjusting their synthesis methods or adding supportive ingredients. This paper reviews the current methods of loading Ag NPs on titanium implants and evaluates their advantages and disadvantages. Methods to increase Ag NPs and reduce their cytotoxicity are also summarized to provide new insights for future research.

Key words: titanium implant, silver nanoparticle, loading method, antibacterial activity, cytotoxicity

中图分类号: 

  • R783.1
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