国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (3): 332-335.doi: 10.7518/gjkq.2017.03.016

• 综述 • 上一篇    下一篇

牙囊细胞及其在牙周组织再生中的应用

杨洋, 徐燕   

  1. 安徽医科大学口腔医学院,安徽医科大学附属口腔医院,安徽省口腔疾病研究中心实验室 合肥 230032
  • 收稿日期:2016-04-23 修回日期:2017-01-07 出版日期:2017-05-01 发布日期:2017-05-01
  • 通讯作者: 徐燕,教授,博士,Email：173236344@qq.com
  • 作者简介:杨洋,硕士,Email：muyigo@163.com
  • 基金资助:
    安徽省自然科学基金（1408085MKL28）

Application of dental follicle cells in periodontal tissue regeneration

Yang Yang, Xu Yan.   

  1. Stomatological Hospital and College, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei 230032, China
  • Received:2016-04-23 Revised:2017-01-07 Online:2017-05-01 Published:2017-05-01
  • Supported by:
    This study was supported by Natural Science Foundation of Anhui Province(1408085MKL28).

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摘要： 牙囊细胞（DFC）来源于外胚间充质,是牙周组织的前体细胞,具有异质性和多向分化的潜能,可以成骨、成牙骨质、成软骨、成脂和成神经向分化。DFC可通过组织块法、酶消化法或两者结合的方法获得,可通过细胞形态鉴定、透射电镜观察和细胞表面特异性标志物检测鉴定,其增殖能力较强。DFC既可以作为种子细胞,复合支架材料形成类似牙周组织的相关结构,也可与其他种子细胞共培养或利用其条件培养液提供的微环境诱导其他种子细胞进行牙周组织的再生,因此在牙周组织再生方面具有广泛的应用前景。

关键词: 牙囊, 干细胞, 牙周组织, 再生

Abstract: Derived from ectodermal mesenchyme, dental follicle cells(DFCs) are periodontal tissue precursor cells that exhibit heterogeneity and multilineage differentiation potential through osteogenic, cementogenic, chondrogenic, adipogenic, and neurogenic differentiation. DFCs are extensively used for periodontal tissue regeneration, because they can be easily harvested from the attached dental follicles, which are separated from the calcified teeth after the impacted third molar extractions. DFCs are suitable seeding cells that can be combined with scaffold to generate periodontal-like tissues and can be co-cultured with other seeding cells or provide microenvironments favorable for tissue regeneration.

Key words: dental follicle, stem cell, periodontal tissue, regeneration

中图分类号: 

  • Q51
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