国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (3): 411-418.doi: 10.7518/gjkq.2025054

• 综述 • 上一篇    

Wnt/β-catenin信号通路在味蕾发育和损伤修复中的作用

郑书豪(),李梓瑕,徐欣()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科 成都 610041
  • 收稿日期:2024-06-14 修回日期:2024-11-07 出版日期:2025-05-01 发布日期:2025-04-30
  • 通讯作者: 徐欣
  • 作者简介:郑书豪，博士，Email：851730340@qq.com
  • 基金资助:
    国家自然科学基金(82370947)

The role of the Wnt/β-catenin signaling pathway in taste bud development and injury reconstruction

Shuhao Zheng(),Zixia Li,Xin Xu()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-06-14 Revised:2024-11-07 Online:2025-05-01 Published:2025-04-30
  • Contact: Xin Xu
  • Supported by:
    National Natural Science Foundation of China(82370947)

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摘要：

Wnt/β-catenin信号通路是哺乳动物调控胚胎发育和组织稳态的重要途径。味蕾作为味觉系统的感受器，产生味觉信号，帮助机体评估食物的毒性和营养成分，对哺乳动物新陈代谢起到重要作用。Wnt/β-catenin信号通路在味蕾的发育和损伤修复过程中发挥了重要的调控作用，并可串话其他信号通路和调控因子，共同参与味蕾和味蕾细胞的稳态维持。本文就Wnt/β-catenin信号通路在味蕾发育和损伤修复中作用的研究进展进行综述，包括Wnt/β-catenin信号通路调控味蕾祖细胞和前体细胞的分化方向、与其他信号通路的协同作用以及维持味蕾的稳态，以期深入了解味蕾发育过程中的关键分子调控机制，为味蕾损伤修复和味觉障碍的防治提供新的思路与策略。

关键词: Wnt/β-catenin信号通路, 味蕾, 味觉细胞, 发育, 损伤修复

Abstract:

The Wnt/β-catenin signaling pathway is a major route by which mammals control embryonic development and tissue homeostasis. The taste buds, a receptor of the taste system, generate taste signals to help the body evaluate the toxicity and nutritional components of food. Thus, taste buds play a vital role in the normal metabolism of mammals. The Wnt/β-catenin signaling pathway plays a crucial regulatory role in the development and reconstruction of taste buds, coordinating with other signaling pathways and regulatory factors to ensure the normal development and homeostasis of taste buds and taste bud cells throughout their life cycle. This review discusses the role of the Wnt/β-catenin signaling pathway in gustatory papilla development and repair. The focus is on the Wnt/β-catenin signaling pathway’s regulation of progenitor and precursor cell differentiation, its interaction with other pathways, and maintenance of homeostasis. New insights into the molecular mechanisms of gustatory papilla development and the prevention and treatment of taste disorders are provided.

Key words: Wnt/β-catenin signaling pathway, taste bud, taste cell, development, injury reconstruction

中图分类号: 

  • R78

图1

Wnt/β-catenin信号通路模式图A: 当靶细胞未接受Wnt信号，β-catenin被降解，Wnt通路受抑制；B：当靶细胞接受到Wnt信号，β-catenin累积入核，Wnt通路被激活。"

图2

轮廓乳头、味蕾和味觉细胞的示意图"

图3

小鼠胚胎中味蕾和舌乳头发育的顺序"

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