国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (3): 405-410.doi: 10.7518/gjkq.2025027

• 综述 • 上一篇    

吲哚菁绿荧光显影技术在口腔鳞状细胞癌手术治疗中的应用进展

买克里亚·艾克帕尔1(),买买提吐逊·吐尔地1,2()   

  1. 1.新疆医科大学第一附属医院（附属口腔医院）口腔颌面创伤正颌外科 乌鲁木齐 830054
    2.新疆维吾尔自治区口腔医学研究所 乌鲁木齐 830054
  • 收稿日期:2024-04-20 修回日期:2024-10-16 出版日期:2025-05-01 发布日期:2025-04-30
  • 通讯作者: 买买提吐逊·吐尔地
  • 作者简介:买克里亚·艾克帕尔，硕士，Email：943126491@qq.com
  • 基金资助:
    国家自然科学基金(82360198)

Progress of research on the application of indocyanine green fluorescence imaging technology in the surgical treatment of oral squamous cell carcinoma

Maikeliya Aikepaer1(),Maimaitituxun Tuerdi1,2()   

  1. 1.Dept. of Oral and Maxillofacial Trauma and Orthognathic Surgery, First Affiliated Hospital (Stomatological Hospital) of Xinjiang Medical University, Urumqi 830054, China
    2.Institute of Stomatology, Xinjiang Uygur Autonomous Region, Urumqi 830054, China
  • Received:2024-04-20 Revised:2024-10-16 Online:2025-05-01 Published:2025-04-30
  • Contact: Maimaitituxun Tuerdi
  • Supported by:
    National Natural Science Foundation of China(82360198)

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摘要：

目前，口腔鳞状细胞癌（OSCC）的手术切除多依赖于临床医生的经验如视诊、触诊及术前影像学检查为参考，缺乏术中实时且客观的评估方法。吲哚菁绿（ICG）作为一种安全且无污染的有机荧光染料，在近红外荧光（NIR）的照射下，聚集在病变部位并显影。此技术应用于OSCC的原发灶及周围血管和神经的显影、前哨淋巴结活检、颈部淋巴结清扫、修复重建中游离皮瓣血运状态的评估等多方面。NIR显影技术未来或许会成为OSCC的早期诊断和精准治疗中关键的一环，本文将以ICG-NIR在OSCC中的应用进行综述。

关键词: 吲哚菁绿, 近红外荧光显影技术, 口腔鳞状细胞癌

Abstract:

The surgical resection of oral squamous cell carcinoma (OSCC) mostly relies on the experience of clinicians, such as visual examination, palpation, and preoperative imaging examination. Real-time and objective intraoperative evaluation methods are also lacking. Indocyanine green (ICG) is a safe and pollution-free organic fluorescent dye that accumulates and develops at a lesion under near-infrared (NIR) fluorescence. This technique can be applied in the visua-lization of primary tumors and surrounding blood vessels and nerves, sentinel lymph-node biopsy, cervical lymph-node dissection, and the evaluation of free-flap blood supply for the repair and reconstruction of OSCC. NIR imaging technology may become a key link in the early diagnosis and precise treatment of OSCC in the future. This article reviews the application of ICG-NIR in OSCC.

Key words: indocyanine green, near infrared fluorescence imaging, oral squamous cell carcinoma

中图分类号: 

  • R739.8
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