国际口腔医学杂志 ›› 2024, Vol. 51 ›› Issue (5): 624-629.doi: 10.7518/gjkq.2024073

• 综述 • 上一篇    下一篇

腭裂术后瘘修复的研究进展

徐一尘(),鲁勇()   

  1. 南京大学医学院附属口腔医院(南京市口腔医院)口腔颌面外科 南京 210008
  • 收稿日期:2023-11-26 修回日期:2024-04-10 出版日期:2024-09-01 发布日期:2024-09-14
  • 通讯作者: 鲁勇
  • 作者简介:徐一尘,住院医师,学士,Email:1837992987@qq.com
  • 基金资助:
    江苏省自然科学基金青年项目(BK20210033)

Advances in the reconstruction of palatal fistula after cleft-palate operation

Yichen Xu(),Yong Lu()   

  1. Dept. of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
  • Received:2023-11-26 Revised:2024-04-10 Online:2024-09-01 Published:2024-09-14
  • Contact: Yong Lu
  • Supported by:
    Natural Science Foundation of Jiangsu Province(BK20210033)

摘要:

腭瘘是腭裂术后的并发症之一,影响患者的口腔卫生、语言功能及心理健康。腭瘘的影响因素和修复方法,如何在修复的同时降低其复发率以及恢复生理功能和美观,是腭瘘修复的研究重点。本文着重叙述了可能导致腭瘘发生的相关因素,如腭裂类型、腭裂宽度、修复术式,以及修复时患者年龄等;进而讨论了腭瘘修复的外科手段,对各种组织瓣的应用进行了分析比较;最后介绍了使用新型材料,包括脱细胞真皮基质、引导组织再生膜、胶原膜和新微创方法修复腭瘘的效果。

关键词: 腭裂, 腭瘘, 分类, 影响因素, 修复方式

Abstract:

Postoperative fistula is one of the complications of cleft-palate repair, affecting oral hygiene, function of language, and mental health. The factors affecting palatal fistula, reconstruction methods, how to reduce its recurrence rate during repair, and how to restore physiological function and aesthetics have become the focus of research on palatal-fistula repair. This article focuses on the factors contributing to the occurrence of palatal fistula, including cleft-palate type, cleft-palate width, reconstructive procedures, and age at the time of repair. Surgical techniques for palatal fistula repair are discussed. Novel materials such as acellular dermal matrix, guided tissue-regeneration membrane, collagen membrane, and minimally invasive approaches to repairing palatal fistula are introduced.

Key words: cleft palate, palatal fistula, classification, factors, reconstruction

中图分类号: 

  • R782.2+2
1 Cohen SR, Kalinowski J, LaRossa D, et al. Cleft palate fistulas: a multivariate statistical analysis of prevalence, etiology, and surgical management[J]. Plast Reconstr Surg, 1991, 87(6): 1041-1047.
2 Smith DM, Vecchione L, Jiang S, et al. The Pittsburgh fistula classification system: a standardized scheme for the description of palatal fistulas[J]. Cleft Palate Craniofacial J, 2007, 44(6): 590-594.
3 Houkes RP, Smit JA, Lachkar N, et al. Unraveling a major burden of orofacial clefts analyses: classification of cleft palate fistulas by cleft surgeons[J]. Cleft Palate Craniofac J, 2024, 61(3): 508-512.
4 Hardwicke JT, Landini G, Richard BM. Fistula incidence after primary cleft palate repair: a systematic review of the literature[J]. Plast Reconstr Surg, 2014, 134(4): 618e-627e.
5 Huang H, Li J, Li C, et al. Sommerlad-Furlow modified palatoplasty: a retrospective study[J]. J Craniomaxillofac Surg, 2023, 51(4): 238-245.
6 Sakran KA, Yin J, Yang R, et al. Evaluation of late cleft palate repair by a modified technique without relaxing incisions[J]. J Stomatol Oral Maxillofac Surg, 2023, 124(4): 101403.
7 Saothonglang K, Punyavong P, Winaikosol K, et al. Risk factors of fistula following primary palatoplasty[J]. J Craniofac Surg, 2021, 32(2): 587-590.
8 Stein MJ, Zhang Z, Fell M, et al. Determining postoperative outcomes after cleft palate repair: a systematic review and meta-analysis[J]. J Plast Reconstr Aesthet Surg, 2019, 72(1): 85-91.
9 Mommaerts MY, Gundlach KK, Tache AN. “Flip-over flap” in two-stage cleft palate repair[J]. J Cranio-maxillofac Surg, 2019, 47(1): 143-148.
10 Eliason MJ, Hadford S, Green L, et al. Incidence of fistula formation and velopharyngeal insufficiency in early versus standard cleft palate repair[J]. J Craniofac Surg, 2020, 31(4): 980-982.
11 Pollard SH, Skirko JR, Dance D, et al. Oronasal fistula risk after palate repair[J]. Cleft Palate Craniofac J, 2021, 58(1): 35-41.
12 Aldaghir OM, AlQuisi AF, Aljumaily HA. Risk factors for fistula development following palatoplasty[J]. J Craniofac Surg, 2019, 30(8): e694-e696.
13 Escher PJ, Zavala H, Lee D, et al. Malnutrition as a risk factor in cleft lip and palate surgery[J]. Laryngoscope, 2021, 131(6): E2060-E2065.
14 Amaratunga NA. Occurrence of oronasal fistulas in operated cleft palate patients[J]. J Oral Maxillofac Surg, 1988, 46(10): 834-838.
15 王洪涛, 黎凡. 早期腭裂修复术后瘘的发生率研究[J]. 中华整形外科杂志, 2003, 19(3): 192-194.
Wang HT, Li F. Clinical study on fistula incidence of early cleft palate repair[J]. Chin J Plast Surg, 2003, 19(3): 192-194.
16 吴敏, 朱祉冰, 石冰, 等. 华西Sommerlad-Furlow腭裂修复术后腭瘘率的研究[J]. 华西口腔医学杂志, 2020, 38(2): 166-169.
Wu M, Zhu ZB, Shi B, et al. Palatal fistula rate after Huaxi Sommerlad-Furlow palatoplasty[J]. West China J Stomatol, 2020, 38(2): 166-169.
17 Tache AN, Mommaerts MY. On the frequency of oronasal fistulation after primary cleft palate repair[J]. Cleft Palate Craniofac J, 2019, 56(10): 1302-1313.
18 Buller M, Jodeh D, Qamar F, et al. Cleft palate fistula: a review[J]. Eplasty, 2023, 23: e7.
19 Abdel-Aziz M, Kamel A, Fawaz M, et al. Closure of fistula of the hard palate with two layers of mucoperiosteum[J]. Int J Pediatr Otorhinolaryngol, 2018, 104: 43-46.
20 Bénateau H, Traoré H, Gilliot B, et al. Repair of pala-tal fistulae in cleft patients[J]. Rev Stomatol Chir Maxillofac, 2011, 112(3): 139-144.
21 石冰. 腭裂术后瘘孔的临床研究进展[J]. 国外医学 · 口腔医学分册, 1999, 26(3): 174-176, 190.
Shi B. Clinical research progress of fistula after cleft palate surgery[J]. Foreign Med Sci (Stomatol), 1999, 26(3): 174-176, 190.
22 Abdaly H, Omranyfard M, Ardekany MR, et al. Buccinator flap as a method for palatal fistula and VPI management[J]. Adv Biomed Res, 2015, 4: 135.
23 Denadai R, Zanco GL, Raposo-Amaral CA, et al. Outcomes of surgical management of palatal fistulae in patients with repaired cleft palate[J]. J Craniofac Surg, 2020, 31(1): e45-e50.
24 Rothermel AT, Lundberg JN, Samson TD, et al. A toolbox of surgical techniques for palatal fistula repair[J]. Cleft Palate Craniofac J, 2021, 58(2): 170-180.
25 Olsson B, Sebastiani AM, Trento GDS, et al. Large anterior oronasal fistula repair using pedicled buccal fat pad and fibroepithelial tissue[J]. J Craniofac Surg, 2019, 30(8): 2618-2620.
26 Gupta N, Shetty S, Degala S. Tongue flap: a “workhorse flap” in repair of recurrent palatal fistulae[J]. Oral Maxillofac Surg, 2020, 24(1): 93-101.
27 Meneses Argalle JD, Espinosa Orozco AM, Prada Madrid JR. Tongue flap for closure of complex oronasal fistula[J]. J Craniofac Surg, 2023, 34(6): 1872-1875.
28 Sohail M, Bashir MM, Khan FA, et al. Comparison of clinical outcome of facial artery myomucosal flap and tongue flap for closure of large anterior palatal fistulas[J]. J Craniofac Surg, 2016, 27(6): 1465-1468.
29 Khismatrao VN, Popat SP, Sharma P, et al. Versatility of facial artery musculomucosal (FAMM) flap for reconstruction of oral cavity defects[J]. J Maxillofac Oral Surg, 2023, 22(1): 44-50.
30 Rahpeyma A, Khajehahmadi S. Facial artery musculomucosal flap in alveolar cleft surgery[J]. Iran J Otorhinolaryngol, 2021, 33(119): 347-353.
31 Ashtiani AK, Emami SA, Rasti M. Closure of complicated palatal fistula with facial artery musculomucosal flap[J]. Plast Reconstr Surg, 2005, 116(2): 381-388.
32 Gadkaree SK, Feng AL, Sharon JD, et al. Compo-site nasoseptal flap for palate reconstruction[J]. J Craniofac Surg, 2019, 30(7): 1990-1993.
33 Fox CM, McKenzie JC, Morris HC, et al. Nasal septal flaps for repair of large or recurrent palatal fistula: report of technique and 4-year experience[J]. Plast Reconstr Surg, 2023, 151(3): 629-633.
34 Spiegel JL, Pilavakis Y, Weiss BG, et al. Quality of life in patients after reconstruction with the supraclavicular artery island flap (SCAIF) versus the radial free forearm flap (RFFF) [J]. Eur Arch Otorhino-laryngol, 2019, 276(8): 2311-2318.
35 Ibrahim B, Rahal A, Bissada E, et al. Reconstruction of medium-size defects of the oral cavity: radial forearm free flap vs facial artery musculo-mucosal flap[J]. J Otolaryngol Head Neck Surg, 2021, 50(1): 67.
36 Bertino G, Lepenne Y, Tinelli C, et al. Radial vs ulnar forearm flap: a preliminary study of donor site morbidity[J]. Acta Otorhinolaryngol Ital, 2019, 39(5): 322-328.
37 Xu Q, Chen PL, Liu YH, et al. Comparing donor site morbidity between radial and ulnar forearm free flaps: a meta-analysis[J]. Br J Oral Maxillofac Surg, 2022, 60(5): 547-553.
38 Pribaz JJ, Singh M, Stephens W, et al. Osteocuta-neous second-toe free flap as alternative option for repair of anterior oronasal fistula: long-term results in selected patients[J]. J Craniofac Surg, 2016, 27(6): 1486-1488.
39 Tork S, Jefferson RC, Janis JE. Acellular dermal matrices: applications in plastic surgery[J]. Semin Plast Surg, 2019, 33(3): 173-184.
40 Simpson A, Samargandi OA, Wong A, et al. Repair of primary cleft palate and oronasal fistula with acellular dermal matrix: a systematic review and surgeon survey[J]. Cleft Palate Craniofac J, 2019, 56(2): 187-195.
41 Emodi O, Ginini JG, van Aalst JA, et al. Cleft palate fistula closure utilizing acellular dermal matrix[J]. Plast Reconstr Surg Glob Open, 2018, 6(3): e1682.
42 Wang YF, Yang FL, Liu WL, et al. Evaluation of the effect of a resorbable membrane on the closure of palatal fistulas[J]. Front Surg, 2023, 10: 1134934.
43 Alonso V, Abuin AS, Duran C, et al. Three-layered repair with a collagen membrane and a mucosal rotational flap reinforced with fibrine for palatal fistula closure in children[J]. Int J Pediatr Otorhinolaryngol, 2019, 127: 109679.
44 Movaniya PN, Makwana TR, Desai NN, et al. Efficacy of collagen membrane graft in intraoral surgery-an evaluative study[J]. Ann Maxillofac Surg, 2021, 11(1): 42-48.
45 Brauner E, Piccoli L, Sallemi K, et al. Evaluation of a novel technique for closure of small palatal fistula[J]. J Pers Med, 2022, 13(1): 65.
46 Saralaya S, Desai AK, Kumar N. Difficulty index-based management of palatal fistula after primary cleft palate repair: an institutional experience[J]. J Oral Maxillofac Surg, 2019, 77(4): 851.e1-851.e7.
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