国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (6): 632-638.doi: 10.7518/gjkq.2023094

• 口颌面发育专栏 • 上一篇    下一篇

维生素与唇腭裂发生相关性的研究进展

夏溦瑶1(),贾仲林2()   

  1. 1.口腔疾病防治全国重点实验室;国家口腔医学中心 国家口腔疾病临床医学研究中心;四川大学华西口腔医学院 成都 610041
    2.口腔疾病防治全国重点实验室;国家口腔医学中心 国家口腔疾病临床医学研究中心;四川大学华西口腔医院唇腭裂外科 成都 610041
  • 收稿日期:2023-03-05 修回日期:2023-08-02 出版日期:2023-11-01 发布日期:2023-10-24
  • 通讯作者: 贾仲林
  • 作者简介:夏溦瑶，硕士，Email：xwy20000615@163.com
  • 基金资助:
    国家自然科学基金面上项目(82170919)

Research progress on the relationship between vitamin and oral clefts

Xia Weiyao1(),Jia Zhonglin2()   

  1. 1.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Disea-ses & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-03-05 Revised:2023-08-02 Online:2023-11-01 Published:2023-10-24
  • Contact: Zhonglin Jia
  • Supported by:
    National Natural Science Foundation of China General Program(82170919)

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摘要：

维生素与唇腭裂发生之间的关系一直受到高度关注，已有大量研究探索维生素对唇腭裂发病机制的影响。维生素可以参与腭形成的调控、影响骨和软骨的发育、改变甲基化水平或在暴露于致畸物时发挥保护作用。母体维生素水平与唇腭裂的发生密切相关，孕期补充复合维生素可以预防或减轻唇腭裂的发生。本文就维生素与唇腭裂发生的关系及其影响机制的研究进展进行综述，为孕期合理补充维生素，预防和减少唇腭裂的发生提供依据。

关键词: 唇腭裂, 维生素, 发病机制

Abstract:

The relationship between vitamins and oral clefts has been a great concern.In recent years, researchers have explored the effects of vitamins on the pathogenesis of oral clefts. Vitamins may regulate palate formation, influence bone and cartilage development, alter methylation levels, or play a protective role during exposure to teratogens. Maternal vitamin levels are strongly associated with the development of oral clefts, and multivitamin supplementation during pregnancy may prevent or mitigate the development of the disease. This article provides a review of the research progress on the relationship between vitamin and oral clefts and the underlying mechanism. Results provide a basis for reasonable vitamin supplementation during pregnancy to prevent and reduce the occurrence of oral clefts.

Key words: oral cleft, vitamin, pathogenesis

中图分类号: 

  • R 782.2
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