国际口腔医学杂志 ›› 2024, Vol. 51 ›› Issue (1): 116-124.doi: 10.7518/gjkq.2024017

• 综述 • 上一篇    

边缘性腭咽闭合不全临床诊疗研究进展

毛奇蓉(),尹恒,李精韬()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院唇腭裂外科 成都 610041
  • 收稿日期:2023-02-14 修回日期:2023-09-25 出版日期:2024-01-01 发布日期:2024-01-10
  • 通讯作者: 李精韬
  • 作者简介:毛奇蓉,硕士,Email:qirong.mao@outlook.com

Progress in the management of marginal velopharyngeal incompetence

Mao Qirong(),Yin Heng,Li Jingtao()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-02-14 Revised:2023-09-25 Online:2024-01-01 Published:2024-01-10
  • Contact: Jingtao Li

摘要:

边缘性腭咽闭合不全(MVPI)是腭裂术后腭咽功能的一类特殊状态。MVPI患者的腭咽生理和语音特征同典型腭咽闭合不全存在显著差异。目前针对MVPI病理机制和诊断标准尚存争议,在手术与非手术治疗方式选择问题上循证依据有限,治疗模式也缺乏相应的公认标准。本文基于对相关文献的系统梳理,明确目前对MVPI诊疗认识不足的具体问题,为进一步探索更加规范合理的MVPI干预模式提供指引。

关键词: 腭裂, 腭咽闭合不全, 语音训练, 手术

Abstract:

Marginal velopharngeal inadequacy (MVPI) is a particular state of postoperative velopharyngeal function after cleft-palate repair. Patients with MVPI demonstrate a unique pattern in velopharyngeal closure and speech performance compared with more evident velopharyngeal insufficiency. Currently, researchers disagree over the pathological mechanism and diagnositic criteria for MVPI. Evidence suggesting the selection of surgical or nonsurgical intervention to MVPI is scarce, and no standard MVPI management protocol is available. By summarizing literature relevant to MVPI management, this review aims to identify aspects of MVPI requiring further investigation and to provide guidance to the exploration of rational evidence-based MVPI management protocol.

Key words: cleft palate, velopharyngeal incompetence, speech therapy, surgery

中图分类号: 

  • R782.2

表 1

2012—2022年文献报道MVPI诊断标准"

时间/年作者主观标准客观标准
2012Patel等[20]PWSS量表评分1~2
2013马思维等[21]有轻度连续和不连续鼻音鼻咽纤维镜检闭合率>0.9
2013Ma等[22]轻度高鼻音和鼻漏气检查者主观判断
2013Jackson等[23]PWSS量表评分≤2
2013Barbosa等[24]闭合时腭咽口面积0.050~19.9 cm2
2014Basta等[25]PWSS量表评分为1~2
2015Hsu等[26]存在轻到中度高鼻音鼻咽纤维镜检闭合率为0.7~0.95
2015Chim等[27]PSA量表评分3~6
2015Scarmagnani等[28]腭咽口闭合时面积为5.0~19.9 mm2
2016Yamaguchi等[29]腭咽口大部分时间能关闭,鼻咽纤维镜检闭合率为0.7~0.95
2016尹恒等[30]存在构音错误和高鼻音症状闭合率在0.9以上
2017Denadai等[31]轻度高鼻音,轻到中度鼻漏气,正常的口内压力
2018Elsherbiny等[32]PWSS量表每项评分均为1
2019Vella等[33]存在短暂高鼻音或鼻漏气,语音正常或接近正常,压力性辅音不受影响
2019Dempsey等[34]PWSS量表评分为1~2
2019Alaluusua等[35]存在短暂高鼻音或鼻漏气,语音正常或接近正常
2020杨艳艳等[36]存在持续或非持续轻度鼻音不同检查时闭合形式不稳定
2022Carr等[37]SLP-3量表评分3~7

图 1

MVPI诊疗流程参考"

1 Kuehn DP, Moller KT. Speech and language issues in the cleft palate population: the state of the art[J]. Cleft Palate Craniofacial J, 2000, 37(4): 1-35.
2 Johns DF, Rohrich RJ, Awada M. Velopharyngeal incompetence: a guide for clinical evaluation[J]. Plast Reconstr Surg, 2003, 112(7): 1890-1897; quiz 1898, 1982.
3 Karnell MP, Schultz K, Canady J. Investigations of a pressure-sensitive theory of marginal velopharyngeal inadequacy[J]. Cleft Palate Craniofacial J, 2001, 38(4): 346-357.
4 Smith B, Guyette TW. Evaluation of cleft palate speech[J]. Clin Plast Surg, 2004, 31(2): 251-260, ix.
5 Riski JE, DeLong E. Articulation development in children with cleft lip/palate[J]. Cleft Palate J, 1984, 21(2): 57-64.
6 Kummer AW. Speech therapy for errors secondary to cleft palate and velopharyngeal dysfunction[J]. Semin Speech Lang, 2011, 32(2): 191-198.
7 Smith BE, Kuehn DP. Speech evaluation of velopharyngeal dysfunction[J]. J Craniofacial Surg, 2007, 18(2): 251-261.
8 Krause CJ, Tharp RF, Morris HL. A comparative study of results of the von Langenbeck and the V-Y pushback palatoplasties[J]. Cleft Palate J, 1976, 13: 11-19.
9 Smith BE, Guyette TW. Pressure-flow differences in performance during production of the CV syllables /pi/ and /pa/[J]. Cleft Palate Craniofacial J, 1996, 33(1): 74-76.
10 Warren DW, Dalston RM, Mayo R. Hypernasality in the presence of “adequate” velopharyngeal closure[J]. Cleft Palate Craniofac J, 1993, 30(2): 150-154.
11 Karnell MP. Nasometric discrimination of hypernasality and turbulent nasal airflow[J]. Cleft Palate Craniofacial J, 1995, 32(2): 145-148.
12 Morris HL, Smith JK. A multiple approach for eva-luating velopharyngeal competency[J]. J Speech Hear Disord, 1962, 27(3): 218-226.
13 Hardin MA, van Demark DR, Morris HL. Long-term speech results of cleft palate speakers with marginal velopharyngeal competence[J]. J Commun Disord, 1990, 23(6): 401-416.
14 Neely BJ, Bradley DP. A rating scale for evaluation of video tape recorded X-ray studies[J]. Cleft Palate J, 1964, 16: 88-94.
15 Hardin MA, Morris HL, Van Demark DR. A study of cleft palate speakers with marginal velopharyngeal competence[J]. J Commun Disord, 1986, 19(6): 461-473.
16 Warren DW, Dalston RM, Trier WC, et al. A pressure-flow technique for quantifying temporal patterns of palatopharyngeal closure[J]. Cleft Palate J, 1985, 22(1): 11-19.
17 Warren DW, Dalston RM, Mayo R. Hypernasality and velopharyngeal impairment[J]. Cleft Palate Craniofacial J, 1994, 31(4): 257-262.
18 Morris HL. Marginal velopharyngeal competence[M]//Winitz H. For clinicians by clinicians, articulation disorders. Baltimore: University Park Press, 1984: 211-222.
19 Jones DL, Morris HL, van Demark DR. A comparison of oral-nasal balance patterns in speakers who are categorized as “almost but not quite” and “sometimes but not always”[J]. Cleft Palate Craniofacial J, 2004, 41(5): 526-534.
20 Patel KB, Sullivan SR, Murthy AS, et al. Speech outcome after palatal repair in nonsyndromic versus syndromic Robin sequence[J]. Plast Reconstr Surg, 2012, 130(4): 577e-584e.
21 马思维, 任战平, 文抑西, 等. 65例腭裂术后MVPI患者构音特点及治疗策略探讨[J]. 实用口腔医学杂志, 2013, 29(6): 844-847.
Ma SW, Ren ZP, Wen YX, et al. Articulation of 65 patients with MVPI and the speech therapy approach after repair of cleft palate[J]. J Pract Stomatol, 2013, 29(6): 844-847.
22 Ma L, Shi B, Li Y, et al. Velopharyngeal function assessment in patients with cleft palate: perceptual speech assessment versus nasopharyngoscopy[J]. J Craniofac Surg, 2013, 24(4): 1229-1231.
23 Jackson O, Stransky CA, Jawad AF, et al. The Children’s Hospital of Philadelphia modification of the Furlow double-opposing Z-palatoplasty: 30-year experience and long-term speech outcomes[J]. Plast Reconstr Surg, 2013, 132(3): 613-622.
24 Barbosa DA, Scarmagnani RH, Fukushiro AP, et al. Surgical outcome of pharyngeal flap surgery and intravelar veloplasty on the velopharyngeal function[J]. Codas, 2013, 25(5): 451-455.
25 Basta MN, Silvestre J, Stransky C, et al. A 35-year experience with syndromic cleft palate repair: operative outcomes and long-term speech function[J]. Ann Plast Surg, 2014, 73(): S130-S135.
26 Hsu PJ, Wang SH, Yun C, et al. Redo double-oppo-sing Z-plasty is effective for correction of marginal velopharyngeal insufficiency[J]. J Plast Reconstr Aesthet Surg, 2015, 68(9): 1215-1220.
27 Chim H, Eshraghi Y, Iamphongsai S, et al. Double-opposing Z-palatoplasty for secondary surgical mana-gement of velopharyngeal incompetence in the absence of a primary Furlow palatoplasty[J]. Cleft Pa-late Craniofac J, 2015, 52(5): 517-524.
28 Scarmagnani RH, Barbosa DA, Fukushiro AP, et al. Relationship between velopharyngeal closure, hypernasality, nasal air emission and nasal rustle in subjects with repaired cleft palate[J]. Codas, 2015, 27(3): 267-272.
29 Yamaguchi K, Lonic D, Lee CH, et al. A treatment protocol for velopharyngeal insufficiency and the outcome[J]. Plast Reconstr Surg, 2016, 138(2): 290e-299e.
30 尹恒, 郭春丽, 石冰, 等. 黏膜下腭裂的形态分类与腭咽功能分析[J]. 华西口腔医学杂志, 2016, 34(5): 488-492.
Yin H, Guo CL, Shi B, et al. Morphological classification and velopharyngeal function analysis of submucous cleft palate patients[J]. West China J Stomatol, 2016, 34(5): 488-492.
31 Denadai R, Sabbag A, Raposo-Amaral CE, et al. Bilateral buccinator myomucosal flap outcomes in nonsyndromic patients with repaired cleft palate and velopharyngeal insufficiency[J]. J Plast Reconstr Aesthet Surg, 2017, 70(11): 1598-1607.
32 Elsherbiny A, Amerson M, Sconyers L, et al. Time course of improvement after re-repair procedure for VPI management[J]. J Plast Reconstr Aesthetic Surg, 2018, 71(6): 895-899.
33 Vella JB, Tatum SA. Risk factors for velopharyngeal dysfunction following orthognathic surgery in the cleft population[J]. Curr Opin Otolaryngol Head Neck Surg, 2019, 27(4): 317-323.
34 Dempsey RF, Elsherbiny A, Amerson M, et al. Normal speech should be the expected outcome in the adopted cleft child[J]. Ann Plast Surg, 2019, 82(6S ): S370-S373.
35 Alaluusua S, Turunen L, Saarikko A, et al. The effects of Le Fort Ⅰ osteotomy on velopharyngeal function in cleft patients[J]. J Cranio Maxillofac Surg, 2019, 47(2): 239-244.
36 杨艳艳, 马思维, 任战平, 等. CPAP在边缘性腭咽闭合功能障碍患者言语治疗中的应用效果评价[J]. 中国美容医学, 2020, 29(9): 49-53.
Yang YY, Ma SW, Ren ZP, et al. The effectiveness of CPAP in speech therapy for cleft palate patients with marginal vealopharyngeal dysfunction[J]. Chin J Aesthetic Med, 2020, 29(9): 49-53.
37 Carr M, Skarlicki M, Palm S, et al. Through-and-through dissection of the soft palate for pharyngeal flap inset: a “good-fast-cheap” technique for any etio-logy of velopharyngeal incompetence[J]. Cleft Pala-te Craniofac J, 2022, 59(6): 785-793.
38 Glade RS, Deal R. Diagnosis and management of velopharyngeal dysfunction[J]. Oral Maxillofac Surg Clin North Am, 2016, 28(2): 181-188.
39 Pamplona C, Ysunza A, Patiño C, et al. Speech summer camp for treating articulation disorders in cleft palate patients[J]. Int J Pediatr Otorhinolaryngol, 2005, 69(3): 351-359.
40 Derakhshandeh F, Nikmaram M, Hosseinabad HH, et al. Speech characteristics after articulation therapy in children with cleft palate and velopharyngeal dysfunction-a single case experimental design[J]. Int J Pediatr Otorhinolaryngol, 2016, 86: 104-113.
41 朱洪平, 孙勇刚, 王光和, 等. 边缘性腭咽闭合的语音声学特点研究[J]. 中华口腔医学杂志, 1998, 33(3): 50-52.
Zhu HP, Sun YG, Wang GH, et al. The study on the acoustic-phonetic features of marginal velopharyngeal closure[J]. Chin J Stomatol, 1998, 33(3): 50-52.
42 Schenck GC, Perry JL, Kollara L, et al. Effects of surgical intervention and continuous positive airway pressure therapy on velopharyngeal structure and function: a case report[J]. Cleft Palate Craniofac J, 2019, 56(4): 525-533.
43 刘琼, 蒋莉萍, 陈阳, 等. 边缘性腭咽闭合不全异常语音治疗方法探讨[J].上海口腔医学, 2011, 20(6): 611-614.
Liu Q, Jiang LP, Chen Y, et al. A preliminary study on speech therapy for marginal velopharyngeal insufficiency[J]. Shanghai J Stomatol, 2011, 20(6): 611-614.
44 陈晓容, 赵彪, 尹恒. 腭裂术后边缘性腭咽闭合不全的语音训练特点[J]. 国际口腔医学杂志, 2011, 38(3): 279-282.
Chen XR, Zhao B, Yin H. The charactristics of speech training for postoperation cleft palate patients who have marginal velopharyngeal insufficiency after palatoplasty[J]. Int J Stomatol, 2011, 38(3): 279-282.
45 李蓓, 石冰, 尹恒, 等. 语音训练对改善轻度腭咽闭合不全患者发音的研究[J]. 华西口腔医学杂志, 2010, 28(6): 623-625.
Li B, Shi B, Yin H, et al. Effects of speech training on velopharyngeal insufficiency in patients with cleft palate[J]. West China J Stomatol, 2010, 28(6): 623-625.
46 Gart MS, Gosain AK. Surgical management of velopharyngeal insufficiency[J]. Clin Plast Surg, 2014, 41(2): 253-270.
47 Abdel-Aziz M, Nassar A, Rashed M, et al. Furlow palatoplasty for previously repaired cleft palate with velopharyngeal insufficiency[J]. Int J Pediatr Otorhinolaryngol, 2015, 79(10): 1748-1751.
48 Dailey SA, Karnell MP, Karnell LH, et al. Comparison of resonance outcomes after pharyngeal flap and Furlow double-opposing z-plasty for surgical management of velopharyngeal incompetence[J]. Cleft Palate Craniofac J, 2006, 43(1): 38-43.
49 Sommerlad BC, Fenn C, Harland K, et al. Submucous cleft palate: a grading system and review of 40 consecutive submucous cleft palate repairs[J]. Cleft Palate Craniofac J, 2004, 41(2): 114-23.
50 Robertson AGN, McKeown DJ, Bello-Rojas G, et al. Use of buccal myomucosal flap in secondary cleft palate repair[J]. Plast Reconstr Surg, 2008, 122(3): 910-917.
51 Impieri D, Tønseth KA, Hide Ø, et al. Autologous fat transplantation to the velopharynx for treating mild velopharyngeal insufficiency: a 10-year expe-rience[J]. J Plast Reconstr Aesthet Surg, 2019, 72(8): 1403-1410.
52 Cofer SA, Baas B, Strand E, et al. Augmentation pharyngoplasty for treatment of velopharyngeal insufficiency in children: results with injectable dextranomer and hyaluronic acid copolymer[J]. Laryngoscope, 2016, 126(): S5-S13.
53 路利丹, 许辉. 自体脂肪移植治疗腭咽闭合不全研究进展[J]. 口腔疾病防治, 2021, 29(2): 135-139.
Lu LD, Xu H. Research progress on autologous fat transplantation in the treatment of velopharyngeal insufficiency[J]. J Prev Treat Stomatol Dis, 2021, 29(2): 135-139.
[1] 夏溦瑶,贾仲林. 维生素与唇腭裂发生相关性的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 632-638.
[2] 陆磊,王鑫,康泽标,谢富强. 计算机辅助导航手术在复杂颌面部骨折中的应用新进展[J]. 国际口腔医学杂志, 2023, 50(6): 696-703.
[3] 刘云通,刘畅,高丽钞,罗瑜雪,曹钰彬,华成舸. 术后下牙槽神经功能障碍的研究进展[J]. 国际口腔医学杂志, 2023, 50(4): 479-484.
[4] 万雪丽,石永乐,张秀芬,王欢,田莉. 唇腭裂患儿全身麻醉苏醒期躁动多维干预体系的构建研究[J]. 国际口腔医学杂志, 2023, 50(3): 272-278.
[5] 陈卓,石冰,李精韬. 唇腭裂患者外鼻生长特征的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 279-286.
[6] 梁芷瑩,赵苑汐,朱嘉妮,苏勤. 288例前牙显微根尖手术临床资料的回顾性分析[J]. 国际口腔医学杂志, 2023, 50(2): 166-171.
[7] 石佳鑫,王淳艺,李精韬. Pierre Robin序列征患者腭裂临床治疗的研究进展[J]. 国际口腔医学杂志, 2023, 50(2): 237-242.
[8] 李精韬, 石冰. 单侧微小型唇裂手术方案与规范化建议[J]. 国际口腔医学杂志, 2023, 50(1): 3-9.
[9] 张宇宁,曾妮,张焙,石冰,郑谦. 咽后壁瓣咽成形术对腭裂术后患者颌面部生长影响的初步研究[J]. 国际口腔医学杂志, 2023, 50(1): 66-71.
[10] 满毅, 黄定明. 美学区种植骨增量与邻牙慢性根尖周病的联合治疗策略(下):临床诊治流程及实践病例[J]. 国际口腔医学杂志, 2022, 49(6): 621-632.
[11] 裴玲,曾妮,杨超,何苗,罗强,石冰,郑谦. 辅助局部麻醉对唇腭裂整复术后镇痛效果的研究[J]. 国际口腔医学杂志, 2022, 49(6): 657-662.
[12] 董栩,徐欣. 根尖倒充填封闭性的体外评价研究进展[J]. 国际口腔医学杂志, 2022, 49(6): 670-677.
[13] 满毅, 黄定明. 美学区种植骨增量与邻牙慢性根尖周病的联合治疗策略(上):应用基础及适应证[J]. 国际口腔医学杂志, 2022, 49(5): 497-505.
[14] 黄艺璇,石冰,李精韬. 唇腭裂患者鼻通气功能的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 453-461.
[15] 马建斌,薛超然,王沛棋,李彬,白丁. 不同补偿间隙3D打印正颌手术𬌗板对咬合精度的影响[J]. 国际口腔医学杂志, 2022, 49(3): 296-304.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张京剧. 青年期至中年期颅面复合体变化的头影测量研究[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 在种植体上制作固定义齿以后下颌骨密度的动态变化[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 王昆润. 二甲亚砜和双氯芬酸并用治疗根尖周炎[J]. 国际口腔医学杂志, 1999, 26(06): .
[4] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[5] 宋红. 青少年牙周炎外周血分叶核粒细胞的趋化功能[J]. 国际口腔医学杂志, 1999, 26(06): .
[6] 高卫民,李幸红. 发达国家牙医学院口腔种植学教学现状[J]. 国际口腔医学杂志, 1999, 26(06): .
[7] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[8] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[9] 轩东英. 不同赋形剂对氢氧化钙抗菌效果的影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[10] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .