Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (1): 64-70.doi: 10.7518/gjkq.2021005

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Research progress on the effects of microenvironment acid-base level in tissue-engineered bone regeneration

Li Peiyi,Zhang Xinchun()   

  1. Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2020-05-12 Revised:2020-09-13 Online:2021-01-01 Published:2021-01-20
  • Contact: Xinchun Zhang E-mail:zhxinch@mail.sysu.edu.cn
  • Supported by:
    The study was supported by Guangdong Basic and Applied Basic Research Foundation(2019A1515010450);the Opening Fund of Laboratory Sun Yat-sen University(201902108)

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Abstract:

After autogenous and xenogeneic bone transplantation therapy, bone tissue engineering has become a new method to repair maxillofacial bone defects. The osteogenic microenvironment is crucial to mobilising regenerative function of biological materials. The regeneration of tissue-engineered bone is affected by pH microenvironment through various osteogenic processes on the surface of artificial bone, such as protein adsorption, migration, adhesion, proliferation and differentiation of osteogenesis-related cells; secretion, maturation and biomineralisation of bone matrix; inflammatory response and vascular reconstruction of bone defects. Neutralising the acid substance in bone defects with alkaline materials correcting the acid microenvironment caused by hypoperfusion and local hypoxia is a potential method to create a suitable network for cell survival and tissue repair. In this paper, the research progress of microenvironment acid-base level in tissue-engineered bone regeneration is reviewed, providing a reference for the development and transformation of artificial bone materials.

Key words: bone tissue engineering, osteogenic microenvironment, acid-base level, bone regeneration


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