Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (5): 572-576.doi: 10.7518/gjkq.2013.05.004

Previous Articles     Next Articles

Detection of Porphyromonas gingivalis in SD rats with chronic periodontitis

Lin Mu, Ren Xiuyun, Chang Le, Yue Zijie, Shi Xuexue, Sun Lili.   

  1. Dept. of Periodontics, Hospital of Stomatology, Shanxi Medical University, Taiyuan 030001, China
  • Received:2013-03-15 Revised:2013-05-24 Online:2013-09-01 Published:2013-09-01

RichHTML

3

PDF (PC)

831

Abstract:

Objective To detect Porphyromonas gingivalis(P.gingivalis) in the carotid artery of rats with chronic periodontitis and to explore the possible relationship between P.gingivalis and chronic periodontitis. Methods Fortytwo SD rats were randomly divided into six groups: Group A(control group), group B1(non-intervention group), group B2(scaling and root planning group), group B3(systemic antibiotics group), group B4(tooth extraction group), and group B5(tooth extraction with antibiotics for 3 d). Each group accepted the corresponding measures and periodontal interventions to establish the animal model. After the death of experimental animals, P.gingivalis was semi-quantitatively detected in the right carotid artery tissue by 16S rRNA polymerase chain reaction. Results P.gingivalis was detected in all groups. The relative quantity of P.gingivalis significantly increased in groups B1 to B5 compared with that in group A(P<0.01). The relative quantity of P.gingivalis was the highest in group B1, showing a significant difference with B4 and B5(P<0.05). A statistically significant difference in the relative quantity of P.gingivalis was also found between B1 and B5(P<0.01). Conclusion P.gingivalis is a periodontal resident pathogen that can invade endothelial cells, leading to associative function disorders. In addition, extraction of loose teeth without delay eliminates P.gingivalis. The intake of antibiotics after tooth extraction decreases the adhesion of P.gingivalis to endothelial cells.

Key words: chronic periodontitis, rat, Porphyromonas gingivalis, endothelial cell


TrendMD: 
[1] Tang Chunbo. Restorative space in edentulous patients and the clinical decision of implant restoration [J]. Int J Stomatol, 2024, 51(1): 1-9.
[2] Chang Xinnan,Liu Lei. Applications and research progress of biodegradable magnesium-based materials in craniomaxillofacial surgery [J]. Int J Stomatol, 2024, 51(1): 107-115.
[3] Zhou Jinkuo,Zhang Jinhong,Shi Xiaojing,Liu Guangshun,Jiang Lei,Liu Qianfeng. Influences of long noncoding RNA small nucleolar RNA host gene 22 on the cell proliferation, invasion and migration of oral squamous carcinoma cells by regulating microRNA-27b-3p [J]. Int J Stomatol, 2024, 51(1): 52-59.
[4] Li Liheng,Wang Rui,Wang Xiaoming,Zhang Zhiyi,Zhang Xuan,An Feng,Wang Qin,Zhang Fan. Effects of circular RNA hsa_circ_0085576 on cell migration and invasion of oral squamous cell carcinoma by regulating the microRNA-498/B-cell-specific Moloney murine leukemia virus integration site 1 axis [J]. Int J Stomatol, 2024, 51(1): 60-67.
[5] Huang Xin,Xu Xiaojie,Zhang Ronghua,Zhao Yuan. A review of pulp calcification and its treatment methods [J]. Int J Stomatol, 2024, 51(1): 82-90.
[6] Hu Jia,Wang Xiuqing,Lu Guoying,Huang Xiaojing.. Regenerative endodontic procedures for permanent tooth with immature apices in adult patients [J]. Int J Stomatol, 2023, 50(6): 686-695.
[7] Huangphattarakul Vicha,Man Yi.. Research progress on mucoperiosteum perforation in maxillary sinus elevation [J]. Int J Stomatol, 2023, 50(5): 552-557.
[8] Wang Renyi,Zhao Chengzhi,Pan Jian.. Research progress on the effects of prophylactic antibiotics on postoperative complications during the perioperative period of tooth extraction [J]. Int J Stomatol, 2023, 50(5): 558-565.
[9] Yu Yuelin,Kong Weidong. Research progress on the association between primary failure of tooth eruption and parathyroid hormone receptor 1 gene [J]. Int J Stomatol, 2023, 50(5): 573-580.
[10] Gong Meiling,Cheng Xingqun,Wu Hongkun.. Research progress on the correlation between Parkinson’s disease and periodontitis [J]. Int J Stomatol, 2023, 50(5): 587-593.
[11] Wang Jiaxi,Mingyue Lü,Yuan Quan. Research progress on sticky bone in oral tissue regeneration [J]. Int J Stomatol, 2023, 50(5): 594-602.
[12] Song Wenpeng,Gong Beiwen,Li Dan,Zeng Jianyu,Qiu Lingling. Research progress on the application of mechanotherapy in orthodontic treatment [J]. Int J Stomatol, 2023, 50(5): 603-612.
[13] Wu Sijia,Shu Chang,Wang Yang,Wang Yuan,Deng Shuli,Wang Huiming.. Effect and research progress on root canal infection management of regenerative endodontic procedure in immature permanent teeth [J]. Int J Stomatol, 2023, 50(4): 388-394.
[14] Wang Gang,Chen Zhuo.. Reduction of the risk of caries after interproximal enamel reduction [J]. Int J Stomatol, 2023, 50(4): 395-400.
[15] Wang Lüya,Zhang Jingxin,Lin Jie.. Postoperative infection control effect of povidone iodine and chlorhexidine: a systematic review and analysis [J]. Int J Stomatol, 2023, 50(4): 438-444.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .