国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (3): 335-339.doi: 10.7518/gjkq.2018.03.017

• 综述 • 上一篇    下一篇

牙周病与阿尔兹海默症的关系

李一涵, 潘兰兰   

  1. 重庆医科大学口腔医学院 重庆医科大学附属口腔医院牙周科 口腔疾病与生物医学重庆市重点实验室 重庆 401147
  • 收稿日期:2017-07-12 修回日期:2018-01-29 发布日期:2018-05-08
  • 通讯作者: 潘兰兰,主治医师,博士,Email：shellypan09@163.com
  • 作者简介:李一涵,硕士,Email：1157697551@qq.com
  • 基金资助:
    重庆市医学科研计划项目（2015MSXM050）

Correlation between periodontal diseases and Alzheimer’s disease

Li Yihan, Pan Lanlan   

  1. School of Stomatology, Chongqing Medical University, Dept. of Periodontology, Stomatological Hospital, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China
  • Received:2017-07-12 Revised:2018-01-29 Published:2018-05-08
  • Supported by:
    This study was supported by Chongqing Medical Research Project (2015MSXM050).

RichHTML

27

PDF (PC)

1025

摘要： 近年来,阿尔兹海默症（AD）患者人数随年龄呈指数式递增,且引发AD的病因至今不明确。多数研究曾表明,AD的发生与年龄老化、遗传因素、炎症反应、氧化应激等多种因素相关。最新研究证实牙周病已是引发多种系统性疾病高危险因素之一,同时有越来越多证据证实牙周病与AD发病存在密切的相关性。牙周病通过产生炎性因子和免疫反应的机制引发AD。本文就牙周病与AD发生相关性及其机制的研究作一综述。

关键词: 阿尔兹海默症, 牙周病, 牙周致病菌, 炎性因子, 免疫反应

Abstract: Alzheimer’s disease (AD) is a chronic, progressive and irreversible neurodegenerative disease. The prevalence of AD increases exponentially with age. Although the pathophysiologic mechanism is not fully understood, inflammation has been confirmedto play a critical role in the pathogenesis of AD. Chronic periodontitisis a chronic immuno-inflammatory disease initiated by complex polymicrobial subgingival biofilm. Periodontal pathogens are implicated in the development of a number of inflammatory pathologies at remote organ sites, including brain tissue where AD occurs. The objective of this review is to present the relationship and possible mechanistic links between periodontal disease and AD.

Key words: Alzheimer’s disease;, periodontitis, periodontal pathogen, cytokines, immune response

中图分类号: 

  • R781.4
[1] Olsen I, Singhrao SK.Can oral infection be a risk factor for Alzheimer’s disease[J]. J Oral Microbiol, 2015, 7:29143.
[2] Martande SS, Pradeep AR, Singh SP, et al.Periodontal health condition in patients with Alzheimer’s disease[J]. Am J Alzheimers Dis Other Demen, 2014, 29(6): 498-502.
[3] Wu Z, Nakanishi H.Connection between periodontitis and Alzheimer’s disease: possible roles of microglia and leptomeningeal cells[J]. J Pharmacol Sci, 2014, 126(1):8-13.
[4] Genco RJ.Current view of risk factors for periodontal diseases[J]. J Periodontol, 1996, 67(10 Suppl):1041-1049.
[5] Gamboa F, Acosta A, García DA, et al.Occurrence of Porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis[J]. Acta Odontol Latinoam, 2014, 27(3):137-144.
[6] Hussain M, Stover CM, Dupont A.P. gingivalis in periodontal disease and atherosclerosis-scenes of action for antimicrobial peptides and complement[J]. Front Immunol, 2015, 6:45.
[7] Kamer AR, Craig RG, Dasanayake AP, et al.Inflam-mation and Alzheimer’s disease: possible role of periodontal diseases[J]. Alzheimers Dement, 2008, 4(4):242-250.
[8] Uppoor AS, Lohi HS, Nayak D.Periodontitis and Alzheimer’s disease: oral systemic link still on the rise[J]. Gerodontology, 2013, 30(3):239-242.
[9] Noble JM, Borrell LN, Papapanou PN, et al.Perio-dontitis is associated with cognitive impairment among older adults: analysis of NHANES-Ⅲ[J]. J Neurol Neurosurg Psychiatry, 2009, 80(11):1206-1211.
[10] Sparks Stein P, Steffen MJ, Smith C, et al.Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease[J]. Alzheimers Dement, 2012, 8(3):196-203.
[11] Poole S, Singhrao SK, Kesavalu L, et al.Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer’s disease brain tissue[J]. J Alzheimers Dis, 2013, 36(4):665-677.
[12] Riviere GR, Riviere KH, Smith KS.Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer’s disease[J]. Oral Microbiol Immunol, 2002, 17(2): 113-118.
[13] Noble JM, Scarmeas N, Celenti RS, et al.Serum IgG antibody levels to periodontal microbiota are asso-ciated with incident Alzheimer disease[J]. PLoS One, 2014, 9(12):e114959.
[14] Grammas P, Ovase R.Inflammatory factors are ele-vated in brain microvessels in Alzheimer’s disease[J]. Neurobiol Aging, 2001, 22(6):837-842.
[15] van Exel E, Eikelenboom P, Comijs H, et al. Va-scular factors and markers of inflammation in off-spring with a parental history of late-onset Alzheimer disease[J]. Arch Gen Psychiatry, 2009, 66(11):1263-1270.
[16] Kamer AR, Craig RG, Pirraglia E, et al.TNF-α and antibodies to periodontal bacteria discriminate be-tween Alzheimer’s disease patients and normal sub-jects[J]. J Neuroimmunol, 2009, 216(1/2):92-97.
[17] Loos BG.Systemic markers of inflammation in perio-dontitis[J]. J Periodontol, 2005, 76(11 Suppl):2106-2115.
[18] Bretz WA, Weyant RJ, Corby PM, et al.Systemic inflammatory markers, periodontal diseases, and periodontal infections in an elderly population[J]. J Am Geriatr Soc, 2005, 53(9):1532-1537.
[19] Kook SY, Seok Hong H, Moon M, et al.Disruption of blood-brain barrier in Alzheimer disease patho-genesis[J]. Tissue Barriers, 2013, 1(2):e23993.
[20] Banks WA, Farr SA, Morley JE.Entry of blood-borne cytokines into the central nervous system: effects on cognitive processes[J]. Neuroimmunomodulation, 2002, 10(6):319-327.
[21] McGeer PL, Rogers J, McGeer EG. Neuroimmune mechanisms in Alzheimer disease pathogenesis[J]. Alzheimer Dis Assoc Disord, 1994, 8(3):149-158.
[22] Grammas P, Ovase R.Inflammatory factors are ele-vated in brain microvessels in Alzheimer’s disease[J]. Neurobiol Aging, 2001, 22(6):837-842.
[23] Akiyama H, Barger S, Barnum S, et al.Inflammation and Alzheimer’s disease[J]. Neurobiol Aging, 2000, 21(3):383-421.
[24] McGeer PL, McGeer EG. Inflammation, autotoxicity and Alzheimer disease[J]. Neurobiol Aging, 2001, 22(6):799-809.
[25] Konsman JP, Drukarch B, Van Dam AM.(Peri)vascular production and action of pro-inflammatory cytokines in brain pathology[J]. Clin Sci, 2007, 112(1):1-25.
[26] Gosselin D, Rivest S.Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system[J]. Brain Behav Immun, 2007, 21(3):281-289.
[27] Engelhart MJ, Geerlings MI, Meijer J, et al.Inflam-matory proteins in plasma and the risk of dementia: the rotterdam study[J]. Arch Neurol, 2004, 61(5): 668-672.
[28] Yaffe K, Kanaya A, Lindquist K, et al.The meta- bolic syndrome, inflammation, and risk of cognitive decline[J]. JAMA, 2004, 292(18):2237-2242.
[29] Schmidt R, Schmidt H, Curb JD, et al.Early inflam-mation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study[J]. Ann Neurol, 2002, 52(2):168-174.
[30] Kálmán J, Juhász A, Laird G, et al.Serum interleu-kin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer’s disease[J]. Acta Neurol Scand, 1997, 96(4):236-240.
[31] Holmes C, El-Okl M, Williams AL, et al.Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer’s disease[J]. J Neurol Neurosurg Psychiatry, 2003, 74(6):788-789.
[32] Nicoll JA, Mrak RE, Graham DI, et al.Association of interleukin-1 gene polymorphisms with Alzheimer’s disease[J]. Ann Neurol, 2000, 47(3):365-368.
[33] Kinane DF, Marshall GJ.Periodontal manifestations of systemic disease[J]. Aust Dent J, 2001, 46(1):2-12.
[34] Forner L, Larsen T, Kilian M, et al.Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation[J]. J Clin Periodontol, 2006, 33(6):401-407.
[35] Savarrio L, Mackenzie D, Riggio M, et al.Detection of bacteraemias during non-surgical root canal treat-ment[J]. J Dent, 2005, 33(4):293-303.
[36] Daly CG, Mitchell DH, Highfield JE, et al.Bacteremia due to periodontal probing: a clinical and microbio-logical investigation[J]. J Periodontol, 2001, 72(2): 210-214.
[37] Tomás I, Alvarez M, Limeres J, et al.Prevalence, duration and aetiology of bacteraemia following dental extractions[J]. Oral Dis, 2007, 13(1):56-62.
[38] Lockhart PB, Bolger AF, Papapanou PN, et al.Perio- dontal disease and atherosclerotic vascular disease: does the evidence support an independent association?: a scientific statement from the American Heart Ass-ociation[J]. Circulation, 2012, 125(20):2520-2544.
[39] Bascones-Martinez A, Matesanz-Perez P, Escribano-Bermejo M, et al.Periodontal disease and diabetes-review of the literature[J]. Med Oral Patol Oral Cir Bucal, 2011, 16(6):e722-e729.
[40] Scannapieco FA.Role of oral bacteria in respiratory infection[J]. J Periodontol, 1999, 70(7):793-802.
[41] Poole S, Singhrao SK, Kesavalu L, et al.Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer’s disease brain tissue[J]. J Alzheimers Dis, 2013, 36(4):665-677.
[42] Poole S, Singhrao SK, Chukkapalli S, et al.Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-/- mice brainsns[J]. J Alzheimers Dis, 2015, 43(1):67-80.
[1] 古丽其合热·阿布来提,秦旭,朱光勋. 线粒体自噬在牙周炎发生发展过程中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 68-73.
[2] 成益凡,秦旭,姜鸣,朱光勋. 牙周病中固有淋巴细胞的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 32-36.
[3] 李伟光,吴亚菲,郭淑娟. 无机纳米粒子在牙周病诊疗中的研究进展[J]. 国际口腔医学杂志, 2022, 49(6): 724-730.
[4] 周剑鹏,谢旭东,赵蕾,王骏. 辅助性T细胞17及白细胞介素17在牙周炎中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 586-592.
[5] 王冠儒,冯强. 牙龈卟啉单胞菌在阿尔兹海默症发生中作用的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 397-403.
[6] 李归平,秦旭,朱光勋. 腺苷酸活化蛋白激酶在牙周病发生发展中的研究进展[J]. 国际口腔医学杂志, 2022, 49(3): 343-348.
[7] 穆新月,刘树泰. 动机性访谈在牙周病患者临床管理中的应用进展[J]. 国际口腔医学杂志, 2022, 49(1): 94-99.
[8] 白皓亮,杨禾,赵蕾. 牙周病风险评估及预后判断工具的研究进展[J]. 国际口腔医学杂志, 2021, 48(6): 696-702.
[9] 周万航,李嫣斐,许日聪,万启军. 牙周非手术治疗对慢性肾脏病危险因素及全身炎症水平影响的Meta分析[J]. 国际口腔医学杂志, 2021, 48(5): 528-535.
[10] 沈忆芬,刘超,汤颖,顾永春. 电子烟暴露对牙周健康影响的研究进展[J]. 国际口腔医学杂志, 2021, 48(3): 347-353.
[11] 秦小茹,刘梦圆. 牙周病和心肌梗死发生风险相关性队列研究的Meta分析[J]. 国际口腔医学杂志, 2021, 48(2): 165-172.
[12] 郏乐铭,贾小玥,杨燃,周学东,徐欣. 益生菌制剂在牙周病防治中的应用进展[J]. 国际口腔医学杂志, 2020, 47(5): 515-521.
[13] 童钰鑫,肖新莉,安莹,张佳喻,石旭妍,王旭,陈悦. 慢性牙周炎对c57小鼠认知能力的影响[J]. 国际口腔医学杂志, 2020, 47(5): 530-537.
[14] 张琳琳,杜毅. 畸形舌侧沟的治疗进展[J]. 国际口腔医学杂志, 2020, 47(4): 458-462.
[15] 王晓宇,朱昭蓉,吴亚菲,赵蕾. 中性粒细胞细胞外陷阱网与牙周炎的相关性研究进展[J]. 国际口腔医学杂志, 2020, 47(3): 304-310.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .