国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (3): 347-353.doi: 10.7518/gjkq.2021048

• 综述 • 上一篇    下一篇

电子烟暴露对牙周健康影响的研究进展

沈忆芬(),刘超,汤颖,顾永春()   

  1. 苏州市第九人民医院中心实验室口腔科 苏州 215200
  • 收稿日期:2020-09-11 修回日期:2021-02-01 出版日期:2021-05-01 发布日期:2021-05-14
  • 通讯作者: 顾永春
  • 作者简介:沈忆芬,主管技师,硕士,Email: 406453632@qq.com
  • 基金资助:
    苏州市吴江区卫生和健康委员会“科教兴卫”项目(wwk-202008)

Research progress on effects of electronic cigarette exposure on periodontal health

Shen Yifen(),Liu Chao,Tang Ying,Gu Yongchun()   

  1. Dept. of Dentistry, Central Laboratory, The Ninth People,s Hospital of Suzhou, Suzhou 215200, China
  • Received:2020-09-11 Revised:2021-02-01 Online:2021-05-01 Published:2021-05-14
  • Contact: Yongchun Gu
  • Supported by:
    Program of “Development of Public Health through Science & Education” of Wujiang Health Commission of Suzhou(wwk-202008)

摘要:

吸烟是牙周疾病一个重要的危险因素。传统香烟在燃烧时会产生数千种有害物质,对牙周组织及细胞存在毒性。电子烟是一种新型烟草制品,它通过电加热及气雾化方式使烟油(由尼古丁、香味物质、溶剂或其他添加剂组成)转化为类似于卷烟烟雾的气溶胶,藉此向吸烟者递送尼古丁。由于电子烟没有燃烧过程,人们普遍认为其危害比传统卷烟小,可以作为传统卷烟的替代品,因此在国内外消费市场发展迅速。然而由于电子烟出现时间较短,国内外关于电子烟对牙周健康长期及短期危害性的评估及研究远比传统香烟少。本文就电子烟暴露对牙周健康影响的研究进展作一综述。

关键词: 电子烟, 口腔健康, 牙周病, 细胞损伤, 吸烟

Abstract:

Cigarette smoking is an important risk factor for periodontal diseases. Over thousands of hazardous com-ponents are present in cigarette smoke during combustion, which may injure the periodontal tissues and cells. Electronic cigarettes (e-cigs) are a novel type of tobacco product. It delivers nicotine through an inhalable aerosol, which is analogous to the mainstream smoke of a conventional cigarette and is generated from electronically heated and aerosolized E-liquids (containing a mixture of nicotine, flavorings, diluents, or other additives). E-cigs are considered less harmful and safer than traditional cigarettes because they do not produce combusted smoke. Therefore, e-cigs have become increasingly popular worldwide. However, only few studies extensively evaluated the long- and short-term effects of e-cigs on the periodontal health, as compared with the abundant detailed investigations on the traditional cigarettes. This article aims to review the research progress on the effects of e-cigs exposure on periodontal health.

Key words: electronic cigarette, oral health, periodontal disease, cellular injury, smoking

中图分类号: 

  • R781.4
[1] 李保江. 全球电子烟市场发展、主要争议及政府管制[J]. 中国烟草学报, 2014,20(4):101-107.
Li BJ. A global perspective on electronic cigarette’s future development and related controversial and re-gulatory issues[J]. Acta Tabacaria Sin, 2014,20(4):101-107.
[2] Goniewicz ML, Knysak J, Gawron M, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes[J]. Tob Control, 2014,23(2):133-139.
doi: 10.1136/tobaccocontrol-2012-050859 pmid: 23467656
[3] 李晟姝, 肖丹, 褚水莲, 等. 北京市吸烟人群使用电子烟情况的调查[J]. 中国临床医生, 2015,43(3):47-49.
Li SS, Xiao D, Chu SL, et al. The survey and analy-sis on electronic cigarette use among urban residen-ces in Beijing[J]. J Chin Physician, 2015,43(3):47-49.
[4] 李威, 江国虹, 徐忠良, 等. 天津市城市居民电子烟使用情况调查结果分析[J]. 中国慢性病预防与控制, 2016,24(7):509-511.
Li W, Jiang GH, Xu ZL, et al. The survey and analy-sis on electronic cigarette use among urban residen-ces in Tianjin[J]. Chin J Prev Contr Chron Dis, 2016,24(7):509-511.
[5] Cressey D. Regulation stacks up for e-cigarettes[J]. Nature, 2013,501(7468):473.
doi: 10.1038/501473a pmid: 24067691
[6] Javed F, Al-Askar M, Samaranayake LP, et al. Perio-dontal disease in habitual cigarette smokers and nonsmokers with and without prediabetes[J]. Am J Med Sci, 2013,345(2):94-98.
doi: 10.1097/MAJ.0b013e31824d5337
[7] Caponnetto P, Campagna D, Papale G, et al. The emerging phenomenon of electronic cigarettes[J]. Expert Rev Respir Med, 2012,6(1):63-74.
doi: 10.1586/ers.11.92 pmid: 22283580
[8] 韩熠, 巩效伟, 洪鎏, 等. 电子烟尼古丁递送及药代动力学研究进展[J]. 中国公共卫生, 2018,34(5):647-651.
Han Y, Gong XW, Hong L, et al. Progress in resear-ches on delivery and pharmacokinetics of nicotine from electronic cigarette: a review[J]. Chin J Public Heal, 2018,34(5):647-651.
[9] Spindle TR, Breland AB, Karaoghlanian NV, et al. Preliminary results of an examination of electronic cigarette user puff topography: the effect of a mouthpiece-based topography measurement device on plasma nicotine and subjective effects[J]. Nicotine Tob Res, 2015,17(2):142-149.
doi: 10.1093/ntr/ntu186
[10] Blount BC, Karwowski MP, Shields PG, et al. Vitamin E acetate in bronchoalveolar-lavage fluid associated with EVALI[J]. N Engl J Med, 2020,382(8):697-705.
doi: 10.1056/NEJMoa1916433
[11] Yan XS, D’Ruiz C. Effects of using electronic cigarettes on nicotine delivery and cardiovascular function in comparison with regular cigarettes[J]. Regul Toxicol Pharmacol, 2015,71(1):24-34.
doi: 10.1016/j.yrtph.2014.11.004
[12] Holliday RS, Campbell J, Preshaw PM. Effect of ni-cotine on human gingival, periodontal ligament and oral epithelial cells. A systematic review of the lite-rature[J]. J Dent, 2019,86:81-88.
doi: S0300-5712(19)30113-7 pmid: 31136818
[13] Hajek P, Phillips-Waller A, Przulj D, et al. A randomized trial of e-cigarettes versus nicotine-replacement therapy[J]. N Engl J Med, 2019,380(7):629-637.
doi: 10.1056/NEJMoa1808779
[14] Beard E, West R, Michie S, et al. Association between electronic cigarette use and changes in quit attempts, success of quit attempts, use of smoking cessation pharmacotherapy, and use of stop smoking services in England: time series analysis of population trends[J]. BMJ, 2016,354:i4645.
[15] Mamudu HM, Sanborn T, Dobbs PD. Electronic ni-cotine delivery systems: recommendations to regulate their use[J]. Am J Public Health, 2019,109(11):1531-1532.
doi: 10.2105/AJPH.2019.305340 pmid: 31577489
[16] Butt YM, Smith ML, Tazelaar HD, et al. Pathology of vaping-associated lung injury[J]. N Engl J Med, 2019,381(18):1780-1781.
doi: 10.1056/NEJMc1913069
[17] Hswen Y, Brownstein JS. Real-time digital surveillance of vaping-induced pulmonary disease[J]. N Engl J Med, 2019,381(18):1778-1780.
doi: 10.1056/NEJMc1912818
[18] Benowitz NL, Fraiman JB. Cardiovascular effects of electronic cigarettes[J]. Nat Rev Cardiol, 2017,14(8):447-456.
doi: 10.1038/nrcardio.2017.36 pmid: 28332500
[19] Layden JE, Ghinai I, Pray I, et al. Pulmonary illness related to e-cigarette use in Illinois and Wisconsin-final report[J]. N Engl J Med, 2020,382(10):903-916.
doi: 10.1056/NEJMoa1911614
[20] Zhao D, Navas-Acien A, Ilievski V, et al. Metal concentrations in electronic cigarette aerosol: effect of open-system and closed-system devices and power settings[J]. Environ Res, 2019,174:125-134.
doi: 10.1016/j.envres.2019.04.003 pmid: WOS:000470801100016
[21] Hwang JH, Lyes M, Sladewski K, et al. Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of co-lonizing bacteria[J]. J Mol Med (Berl), 2016,94(6):667-679.
doi: 10.1007/s00109-016-1378-3
[22] Mokeem SA, Alasqah MN, Michelogiannakis D, et al. Clinical and radiographic periodontal status and whole salivary cotinine, IL-1β and IL-6 levels in cigarette-and waterpipe-smokers and e-cig users[J]. Environ Toxicol Pharmacol, 2018,61:38-43.
doi: 10.1016/j.etap.2018.05.016
[23] Akinkugbe AA. Cigarettes, e-cigarettes, and adolescents’ oral health: findings from the population assessment of tobacco and health (PATH) study[J]. JDR Clin Transl Res, 2019,4(3):276-283.
[24] Javed F, Abduljabbar T, Vohra F, et al. Comparison of periodontal parameters and self-perceived oral symptoms among cigarette smokers, individuals va-ping electronic cigarettes, and never-smokers[J]. J Periodontol, 2017,88(10):1059-1065.
doi: 10.1902/jop.2017.170197
[25] Al-Aali KA, Alrabiah M, ArRejaie AS, et al. Peri-implant parameters, tumor necrosis factor-alpha, and interleukin-1 beta levels in vaping individuals[J]. Clin Implant Dent Relat Res, 2018,20(3):410-415.
doi: 10.1111/cid.12597 pmid: 29575755
[26] Vora MV, Chaffee BW. Tobacco-use patterns and self-reported oral health outcomes: a cross-sectional assessment of the Population Assessment of Tobacco and Health study, 2013-2014[J]. J Am Dent Assoc, 2019,150(5):332-344.e2.
doi: 10.1016/j.adaj.2018.12.004
[27] Huilgol P, Bhatt SP, Biligowda N, et al. Association of e-cigarette use with oral health: a population-based cross-sectional questionnaire study[J]. J Public Health (Oxf), 2019,41(2):354-361.
[28] Tatullo M, Gentile S, Paduano F, et al. Crosstalk between oral and general health status in e-smokers[J]. Medicine (Baltimore), 2016,95(49):e5589.
doi: 10.1097/MD.0000000000005589
[29] Wadia R, Booth V, Yap HF, et al. A pilot study of the gingival response when smokers switch from smo-king to vaping[J]. Br Dent J, 2016,221(11):722-726.
doi: 10.1038/sj.bdj.2016.914 pmid: 27932811
[30] Wu LZ, Duan DM, Liu YF, et al. Nicotine favors osteoclastogenesis in human periodontal ligament cells co-cultured with CD4+ T cells by upregulating IL-1β[J]. Int J Mol Med, 2013,31(4):938-942.
doi: 10.3892/ijmm.2013.1259
[31] King BA, Patel R, Nguyen KH, et al. Trends in awa-reness and use of electronic cigarettes among US adults, 2010-2013[J]. Nicotine Tob Res, 2015,17(2):219-227.
doi: 10.1093/ntr/ntu191
[32] Tinti F, Soory M. Oxidative actions of hydrogen pe-roxide in human gingival and oral periosteal fibroblasts: responses to glutathione and nicotine, relevant to healing in a redox environment[J]. Redox Biol, 2013,2:36-43.
doi: 10.1016/j.redox.2013.11.008
[33] Yang X, Qi Y, Avercenc-Leger L, et al. Effect of nicotine on the proliferation and chondrogenic differentiation of the human Wharton’s jelly mesenchymal stem cells[J]. Biomed Mater Eng, 2017,28(s1):S217-S228.
[34] Alanazi H, Park HJ, Chakir J, et al. Comparative study of the effects of cigarette smoke and electro-nic cigarettes on human gingival fibroblast proliferation, migration and apoptosis[J]. Food Chem Toxicol, 2018,118:390-398.
doi: 10.1016/j.fct.2018.05.049
[35] Sánchez-Pérez A, Moya-Villaescusa MJ, Caffesse RG. Tobacco as a risk factor for survival of dental implants[J]. J Periodontol, 2007,78(2):351-359.
pmid: 17274726
[36] Rouabhia M, Alanazi H, Park HJ, et al. Cigarette smoke and e-cigarette vapor dysregulate osteoblast interaction with titanium dental implant surface[J]. J Oral Implantol, 2019,45(1):2-11.
doi: 10.1563/aaid-joi-D-18-00009 pmid: 30160606
[37] Sancilio S, Gallorini M, Cataldi A, et al. Cytotoxicity and apoptosis induction by e-cigarette fluids in human gingival fibroblasts[J]. Clin Oral Investig, 2016,20(3):477-483.
doi: 10.1007/s00784-015-1537-x pmid: 26239821
[38] Sundar IK, Javed F, Romanos GE, et al. E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts[J]. Oncotarget, 2016,7(47):77196-77204.
doi: 10.18632/oncotarget.12857 pmid: 27791204
[39] Willershausen I, Wolf T, Weyer V, et al. Influence of e-smoking liquids on human periodontal ligament fibroblasts[J]. Head Face Med, 2014,10:39.
doi: 10.1186/1746-160X-10-39 pmid: 25224853
[40] Muthumalage T, Prinz M, Ansah KO, et al. Inflammatory and oxidative responses induced by exposure to commonly used e-cigarette flavoring chemicals and flavored e-liquids without nicotine[J]. Front Physiol, 2018,8:1130.
doi: 10.3389/fphys.2017.01130
[41] Karasneh JA, Al Habashneh RA, Marzouka NAS, et al. Effect of cigarette smoking on subgingival bacteria in healthy subjects and patients with chronic pe-riodontitis[J]. BMC Oral Heal, 2017,17(1):64.
[42] Stewart CJ, Auchtung TA, Ajami NJ, et al. Effects of tobacco smoke and electronic cigarette vapor exposure on the oral and gut microbiota in humans: a pilot study[J]. PeerJ, 2018,6:e4693.
doi: 10.7717/peerj.4693
[43] Nelson JM, Cuadra GA, Palazzolo DL. A comparison of flavorless electronic cigarette-generated aerosol and conventional cigarette smoke on the planktonic growth of common oral commensal Streptococci[J]. Int J Environ Res Public Health, 2019,16(24):5004.
doi: 10.3390/ijerph16245004
[44] 姜垣, 李强, 肖琳, 等. 中国烟草流行与控制[J]. 中华流行病学杂志, 2011,32(12):1181-1187.
pmid: 22336596
Jiang Y, Li Q, Xiao L, et al. Epidemic and control on tobacco in China[J]. Chin J Epidemiol, 2011,32(12):1181-1187.
pmid: 22336596
[45] Britton J, Arnott D, McNeill A, et al. Nicotine without smoke-putting electronic cigarettes in context[J]. BMJ, 2016,353:i1745.
[46] McNeill A, Brose LS, Calder R, et al. E-cigarettes: an evidence update. A report commissioned by Public Health England[R]. London: Public Health England, 2015.
[1] 秦小茹,刘梦圆. 牙周病和心肌梗死发生风险相关性队列研究的Meta分析[J]. 国际口腔医学杂志, 2021, 48(2): 165-172.
[2] 郏乐铭,贾小玥,杨燃,周学东,徐欣. 益生菌制剂在牙周病防治中的应用进展[J]. 国际口腔医学杂志, 2020, 47(5): 515-521.
[3] 邓晓宇,张蕴涵,邹静. 低龄儿童龋的早期生物学管理[J]. 国际口腔医学杂志, 2020, 47(5): 581-588.
[4] 张琳琳,杜毅. 畸形舌侧沟的治疗进展[J]. 国际口腔医学杂志, 2020, 47(4): 458-462.
[5] 刘琳,周婕妤,吴亚菲,赵蕾. 益生菌生态调节在牙周病防治中的应用[J]. 国际口腔医学杂志, 2020, 47(2): 131-137.
[6] 胡静,戴艳梅,冯昭飞. 基于氟牙症流行特征的天津市12~14岁青少年口腔健康抽样调查分析[J]. 国际口腔医学杂志, 2019, 46(6): 650-656.
[7] 程国平,丁一,郭淑娟. 静电纺丝纤维作为牙周药物传递系统的研究进展[J]. 国际口腔医学杂志, 2019, 46(5): 565-570.
[8] 张佳喻,罗宁,苗棣,应绚,陈悦. 意向性牙再植治疗重度牙周炎患牙的临床研究[J]. 国际口腔医学杂志, 2019, 46(4): 400-406.
[9] 胡竹林,赵诣,李茵. 口腔龈沟液生物标志物的检测分析现状及临床应用前景展望[J]. 国际口腔医学杂志, 2019, 46(3): 308-315.
[10] 郭淑娟, 刘倩, 丁一. 牙周病和植体周病国际新分类简介[J]. 国际口腔医学杂志, 2019, 46(2): 125-134.
[11] 闫凯娴,李纾. 非牙周病性龈病损[J]. 国际口腔医学杂志, 2019, 46(2): 177-185.
[12] 董正谋,刘锐,刘鲁川,温秀杰. 种子细胞在牙周组织再生治疗中的研究进展[J]. 国际口腔医学杂志, 2019, 46(1): 48-54.
[13] 叶畅畅, 赵蕾, 王冬青, 王晓丽, 王海燕, 游梦, 黄萍, 吴亚菲. 妊娠期牙周疾病的防治策略[J]. 国际口腔医学杂志, 2018, 45(5): 501-508.
[14] 游文喆, 夏斌. 精神/智力残疾儿童的口腔健康促进和维护[J]. 国际口腔医学杂志, 2018, 45(4): 492-496.
[15] 李一涵, 潘兰兰. 牙周病与阿尔兹海默症的关系[J]. 国际口腔医学杂志, 2018, 45(3): 335-339.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 高卫民,李幸红. 发达国家牙医学院口腔种植学教学现状[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] . 第4届中日口腔医学大会征稿通知[J]. 国际口腔医学杂志, 2008, 35(S1): .
[4] 沈末伦,华成舸. 上皮间质转化及其调控基因Twist在肿瘤侵袭转移中的作用[J]. 国际口腔医学杂志, 2008, 35(S1): .
[5] 周晗 张陶 岳源 乔梦婷 李燕 肖丽英. 葡萄多酚和茶多酚抗变异链球菌活性的比较[J]. 国际口腔医学杂志, 2011, 38(6): 643 -648 .
[6] 张丽摘 丁刚校. 深冷冻对根尖牙乳头干细胞生物学特性和免疫学特性的影响[J]. 国际口腔医学杂志, 2011, 38(6): 720 .
[7] 昝琳, 林宝山, 邓潇, 陈嵩. 不同生长期安氏Ⅱ类1 分类错牙合畸形患者非拔牙矫治的疗效评估[J]. 国际口腔医学杂志, 2009, 36(3): 276 -280 .
[8] 周利文1 高永波1 李莉莉2 舒香云1 林东晓1 陈丽璇1. 局域层流种植手术室动态环境下尘埃粒子数的研究[J]. 国际口腔医学杂志, 2013, 40(4): 454 -455 .
[9] 宋文婷1 刘光涛2 隋秋丽3 陈渊3 葛林3 林梅3. 音乐对味觉辨别阈的影响[J]. 国际口腔医学杂志, 2013, 40(4): 459 -461 .
[10] 李晓宁综述 樊明文 杨雪超审校. 牙髓病治疗新材料BioAggregate的研究进展[J]. 国际口腔医学杂志, 2013, 40(4): 471 -472 .