国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (6): 670-674.doi: 10.7518/gjkq.2019076

• 综述 • 上一篇    下一篇

牙龈卟啉单胞菌外膜囊泡的研究进展

张智颖1,刘东娟2,潘亚萍1()   

  1. 1. 中国医科大学口腔医院牙周科 沈阳 110002
    2. 中国医科大学口腔医院综合急诊黏膜病科 沈阳 110002
  • 收稿日期:2019-01-21 修回日期:2019-05-21 出版日期:2019-11-01 发布日期:2019-11-14
  • 通讯作者: 潘亚萍 E-mail:yppan@cmu.edu.cn
  • 作者简介:张智颖,硕士,Email： 372771916@qq.com
  • 基金资助:
    国家自然科学基金(81670997);中国博士后基金面上项目(2018M640269)

Research progress on Porphyromonas gingivalis outer membrane vesicles

Zhang Zhiying1,Liu Dongjuan2,Pan Yaping1()   

  1. 1. Dept. of Peridontology, Hospital of Stomatology, China Medical University, Shenyang 110002, China
    2. Dept. of Emergency and Oral Medicine, Hospital of Stomatology, China Medical University, Shenyang 110002, China
  • Received:2019-01-21 Revised:2019-05-21 Online:2019-11-01 Published:2019-11-14
  • Contact: Yaping Pan E-mail:yppan@cmu.edu.cn
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81670997);Postdoctoral Funds in China(2018M640269)

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摘要：

牙龈卟啉单胞菌是主要的牙周致病菌之一。研究表明,牙龈卟啉单胞菌外膜囊泡能够与宿主细胞及其他微生物进行信息交流,传递毒力因子,从而使宿主细胞发生改变。外膜囊泡包含的毒力因子主要有黏附素和蛋白酶等,在牙龈卟啉单胞菌致病过程中发挥重要作用。本文就牙龈卟啉单胞菌外膜囊泡的发生及其在牙龈卟啉单胞菌致病过程中的作用进行综述,为对牙龈卟啉单胞菌外膜囊泡进行深入研究提供参考。

关键词: 牙周炎, 牙龈卟啉单胞菌, 外膜囊泡

Abstract:

Porphyromonas gingivalis is one of the major periodontal pathogens. Studies have shown that outer membrane vesicle (OMV) can exchange information with host cells and other microorganisms and transmit virulence factors to cause changes in host cells. Virulence factors contained in OMV mainly include adhesins and proteolytic enzymes, which play important roles in the pathogenesis of Porphyromonas gingivalis infection. This paper reviews the occurrence of Porphyromonas gingivalis OMV and its role in the pathogenesis of Porphyromonas gingivalis infection, thereby providing a reference for the in-depth study ofPorphyromonas gingivalis OMV.

Key words: periodontitis, Porphyromonas gingivalis, outer membrane vesicle

中图分类号: 

  • Q256
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