国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (2): 197-202.doi: 10.7518/gjkq.2019024
Ran Nie,Tianqi Guo,Xue Li,Tingting Pei,Qin Qin,Yanmin. Zhou()
摘要:
组织蛋白酶是溶酶体中的蛋白质水解酶,在全身疾病(如肿瘤、骨质疏松症、类风湿性关节炎)中的致病作用是当今的研究热点,有大量研究表明其与牙周炎的发生、发展密切相关。组织蛋白酶对于牙周炎的研究以及临床预防和减轻牙周炎具有重要意义。本文就与牙周炎相关的组织蛋白酶K、B、C、G的结构与功能、致病机制及相关抑制剂进行综述。
中图分类号:
[1] |
Stoka V, Turk V, Turk B . Lysosomal cathepsins and their regulation in aging and neurodegeneration[J]. Ageing Res Rev, 2016,32:22-37.
doi: 10.1016/j.arr.2016.04.010 pmid: 27125852 |
[2] |
Novinec M, Kovacic L, Lenarcic B , et al. Conforma-tional flexibility and allosteric regulation of cathepsin K[J]. Biochem J, 2010,429(2):379-389.
doi: 10.1042/BJ20100337 pmid: 20450492 |
[3] |
Mort JS, Beaudry F, Théroux K , et al. Early cathepsin K degradation of type Ⅱ collagen in vitro and in vivo in articular cartilage[J]. Osteoarthritis Cartilage, 2016,24(8):1461-1469.
doi: 10.1016/j.joca.2016.03.016 pmid: 27049030 |
[4] |
Duong LT . Therapeutic inhibition of cathepsin K—reducing bone resorption while maintaining bone formation[J]. Bonekey Rep, 2012,1:67.
doi: 10.1038/bonekey.2012.67 pmid: 3727753 |
[5] |
Mogi M, Otogoto J . Expression of cathepsin-K in gingival crevicular fluid of patients with periodontitis[J]. Arch Oral Biol, 2007,52(9):894-898.
doi: 10.1016/j.archoralbio.2007.01.006 pmid: 17321485 |
[6] |
Li YP, Chen W . Characterization of mouse cathepsin K gene, the gene promoter, and the gene expression[J]. JBMR, 1999,14(4):487-499.
doi: 10.1359/jbmr.1999.14.4.487 pmid: 11393791 |
[7] |
Balkan W, Martinez AF, Fernandez I , et al. Identi-fication of NFAT binding sites that mediate stimula-tion of cathepsin K promoter activity by RANK ligand[J]. Gene, 2009,446(2):90-98.
doi: 10.1016/j.gene.2009.06.013 |
[8] |
Kamolmatyakul S, Chen W, Yang S , et al. IL-1α stimulates cathepsin K expression in osteoclasts via the tyrosine kinase-NF-κB pathway[J]. J Dent Res, 2004,83(10):791-796.
doi: 10.1177/154405910408301011 pmid: 3966556 |
[9] |
Knapik DM, Perera P, Nam J , et al. Mechanosignaling in bone health, trauma and inflammation[J]. Antioxid Redox Signal, 2014,20(6):970-985.
doi: 10.1089/ars.2013.5467 pmid: 3924811 |
[10] |
Romas E, Gillespie MT, Martin TJ . Involvement of receptor activator of NFκB ligand and tumor necrosis factor-α in bone destruction in rheumatoid arthritis[J]. Bone, 2002,30(2):340-346.
doi: 10.1016/S8756-3282(01)00682-2 |
[11] |
Hao L, Chen J, Zhu Z , et al. Odanacatib, a cathepsin K-specific inhibitor, inhibits inflammation and bone loss caused by periodontal diseases[J]. J Periodontol, 2015,86(8):972-983.
doi: 10.1902/jop.2015.140643 pmid: 4648620 |
[12] |
Hao L, Zhu G, Lu Y , et al. Deficiency of cathepsin K prevents inflammation and bone erosion in rheuma-toid arthritis and periodontitis and reveals its shared osteoimmune role[J]. FEBS Lett, 2015,589(12):1331-1339.
doi: 10.1016/j.febslet.2015.04.008 pmid: 4623593 |
[13] |
Chen W, Gao B, Hao L , et al. The silencing of cathe-psin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation[J]. J Periodontal Res, 2016,51(5):647-660.
doi: 10.1111/jre.12345 pmid: 26754272 |
[14] |
Fong D, Chan MM, Hsieh WT , et al. Confirmation of the human cathepsin B gene (CTSB) assignment to chromosome 8[J]. Hum Genet, 1992,89(1):10-12.
doi: 10.1007/BF00207033 pmid: 1577456 |
[15] |
Illy C, Quraishi O, Wang J , et al. Role of the occlu-ding loop in cathepsin B activity[J]. J Biol Chem, 1997,272(2):1197-1202.
doi: 10.1074/jbc.272.2.1197 pmid: 8995421 |
[16] |
Musil D, Zucic D, Turk D , et al. The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity[J]. EMBO J, 1991,10(9):2321-2330.
doi: 10.1002/embj.1991.10.issue-9 |
[17] |
Gondi CS, Rao JS . Cathepsin B as a cancer target[J]. Expert Opin Ther Targets, 2013,17(3):281-291.
doi: 10.4149/neo_2015_003 pmid: 25563363 |
[18] |
Cox SW, Eley BM, Kiili M , et al. Collagen degra-dation by interleukin-1β-stimulated gingival fibro-blasts is accompanied by release and activation of multiple matrix metalloproteinases and cysteine proteinases[J]. Oral Dis, 2006,12(1):34-40.
doi: 10.1111/j.1601-0825.2005.01153.x pmid: 16390466 |
[19] |
Li X, Wu Z, Ni J , et al. Cathepsin B regulates collagen expression by fibroblasts via prolonging TLR2/NF-κB activation[J]. Oxid Med Cell Longev, 2016,2016:7894247.
doi: 10.1155/2016/7894247 pmid: 27648120 |
[20] |
Kennett CN, Cox SW, Eley BM . Ultrastructural localization of cathepsin B in gingival tissue from chronic periodontitis patients[J]. Histochem J, 1997,29(10):727-734.
doi: 10.1023/A:1026465118281 pmid: 9429076 |
[21] |
Holden JA, Attard TJ, Laughton KM , et al. Por-phyromonas gingivalis lipopolysaccharide weakly activates M1 and M2 polarized mouse macrophages but induces inflammatory cytokines[J]. Infect Im-mun, 2014,82(10):4190-4203.
doi: 10.1128/IAI.02325-14 pmid: 25047849 |
[22] | 常晓彤, 辇晓峰, 王振辉 . Toll样受体信号转导途径研究进展[J]. 生理科学进展, 2011,42(5):340-346. |
Chang XT, Nian XF, Wang ZH . Progress of research on TLRs-mediated signaling pathway[J]. Prog Physiol Sci, 2011,42(5):340-346. | |
[23] |
李倩, 周学东, 樊亚平 , 等. 慢性牙周炎患者唾液蛋白酶谱分析[J]. 华西口腔医学杂志, 2017,35(1):37-42.
doi: 10.7518/hxkq.2017.01.005 |
Li Q, Zhou XD, Fan YP . Analysis of salivary pro-tease spectrum in chronic periodontitis[J]. West Chin J Stomatol, 2017,35(1):37-42.
doi: 10.7518/hxkq.2017.01.005 |
|
[24] |
Hamon Y, Legowska M, Fergelot P , et al. Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome[J]. FEBS J, 2016,283(3):498-509.
doi: 10.1111/febs.13605 pmid: 26607765 |
[25] |
Sørensen OE, Clemmensen SN, Dahl SL , et al. Pa-pillon-Lefèvre syndrome patient reveals species-de-pendent requirements for neutrophil defenses[J]. J Clin Invest, 2014,124(10):4539-4548.
doi: 10.1172/JCI76009 pmid: 4191054 |
[26] | 王津津 . 组织蛋白酶C在牙周炎症反应中的功能初探[D]. 西安: 第四军医大学, 2015. |
Wang JJ . A pilot study about the effect of cathepsin C on the periodontal inflammation response[D]. Xi’an: Fourth Military Medical University, 2015. | |
[27] |
Khan FY, Jan SM, Mushtaq M . Papillon-Lefevre syndrome (PLS) without cathepsin C mutation: a rare early onset partially penetrant variant of PLS[J]. Saudi Dent J, 2014,26(1):25-28.
doi: 10.1016/j.sdentj.2013.12.004 pmid: 24526825 |
[28] |
Türkoğlu O, Azarsız E, Emingil G , et al. Are pro-teinase 3 and cathepsin C enzymes related to patho-genesis of periodontitis[J]. Biomed Res Int, 2014,2014:420830.
doi: 10.1155/2014/420830 pmid: 4052470 |
[29] |
Kosikowska P, Lesner A . Inhibitors of cathepsin G: a patent review (2005 to present)[J]. Expert Opin Ther Pat, 2013,23(12):1611-1624.
doi: 10.1517/13543776.2013.835397 pmid: 24079661 |
[30] | 孟焕新 . 牙周病学[M]. 北京: 人民卫生出版社, 2013: 97. |
Meng HX. Periodontology[M]. Beijing: People’s Health Publishing House, 2013: 97. | |
[31] |
Kurtulus Waschulewski I, Gökbuget AY, Christiansen NM , et al. Immunohistochemical analysis of the gingiva with periodontitis of type Ⅰ plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva[J]. Arch Oral Biol, 2016,72:75-86.
doi: 10.1016/j.archoralbio.2016.07.013 pmid: 27552374 |
[32] |
Gul SS, Douglas CW, Griffiths GS , et al. A pilot study of active enzyme levels in gingival crevicular fluid of patients with chronic periodontal disease[J]. J Clin Periodontol, 2016,43(8):629-636.
doi: 10.1111/jcpe.12568 pmid: 27106161 |
[33] |
Mukherjee K, Chattopadhyay N . Pharmacological inhibition of cathepsin K: a promising novel approach for postmenopausal osteoporosis therapy[J]. Biochem Pharmacol, 2016,117:10-19.
doi: 10.1016/j.bcp.2016.04.010 pmid: 27106079 |
[34] | 黄伟 . 双磷酸盐相关性颌骨坏死的循证治疗与动物实验模型建立[D]. 武汉: 武汉大学, 2013. |
Huang W . Evidence-based therapy and animal model establishment of bisphosphate-related jaw necrosis[D]. Wuhan: Wuhan University, 2013. | |
[35] |
Tabatabaei-Malazy O, Salari P, Khashayar P , et al. New horizons in treatment of osteoporosis[J]. Daru, 2017,25(1):2.
doi: 10.1186/s40199-017-0167-z pmid: 28173850 |
[36] |
Li YY, Fang J, Ao GZ . Cathepsin B and L inhibitors: a patent review (2010-present)[J]. Expert Opin Ther Pat, 2017,27(6):643-656.
doi: 10.1080/13543776.2017.1272572 pmid: 27998201 |
[37] |
Kos J, Mitrović A, Mirković B . The current stage of cathepsin B inhibitors as potential anticancer agents[J]. Future Med Chem, 2014,6(11):1355-1371.
doi: 10.4155/fmc.14.73 pmid: 25163003 |
[38] |
Guay D, Beaulieu C, Percival MD . Therapeutic utility and medicinal chemistry of cathepsin C inhibitors[J]. Curr Top Med Chem, 2010,10(7):708-716.
doi: 10.2174/156802610791113469 pmid: 20337582 |
[1] | 傅豫, 何薇, 黄兰. 铁死亡在口腔疾病中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 36-44. |
[2] | 罗晓洁,王德续,陈晓涛. 基于生物信息学分析铁死亡调控基因与牙周炎的关系[J]. 国际口腔医学杂志, 2023, 50(6): 661-668. |
[3] | 黄元鸿,彭显,周学东. 骨碎补在治疗口腔骨相关疾病的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 679-685. |
[4] | 龚美灵,程兴群,吴红崑. 牙周炎与帕金森病相关性的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 587-593. |
[5] | 孙佳,韩烨,侯建霞. 白细胞介素-6-铁调素信号轴调控牙周炎相关性贫血致病机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 329-334. |
[6] | 刘体倩,梁星,刘蔚晴,李晓虹,朱睿. 咬合创伤在牙周炎发生发展中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 19-24. |
[7] | 李琼,于维先. 白藜芦醇治疗牙周炎及其生物利用度的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 25-31. |
[8] | 黄伟琨,徐秋艳,周婷. 黄芩苷抑制脂多糖促巨噬细胞氧化应激损伤作用的研究[J]. 国际口腔医学杂志, 2022, 49(5): 521-528. |
[9] | 周剑鹏,谢旭东,赵蕾,王骏. 辅助性T细胞17及白细胞介素17在牙周炎中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 586-592. |
[10] | 陈荟宇,白明茹,叶玲. 信号素3A与口腔常见病关系的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 593-599. |
[11] | 周佳佳,赵蕾,徐欣. 牙周炎相关基因多态性的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 432-440. |
[12] | 马玉,左玉,张鑫. 光动力疗法辅助治疗牙周炎治疗效果的Meta分析[J]. 国际口腔医学杂志, 2022, 49(3): 305-316. |
[13] | 钱素婷,丁玲敏,纪雅宁,林军. 微小RNA在牙周炎龈沟液中的表达差异及对牙周炎的调控机制[J]. 国际口腔医学杂志, 2022, 49(3): 349-355. |
[14] | 蒋端,申道南,赵蕾,吴亚菲. 内皮发育调节基因-1与牙周炎相关性的研究进展[J]. 国际口腔医学杂志, 2022, 49(2): 244-248. |
[15] | 安宁,李姣,梅志丹. 骨保护素/核因子-κB受体活化因子/核因子κB-受体活化因子配体信号分子调控牙萌出的研究进展[J]. 国际口腔医学杂志, 2022, 49(1): 116-120. |
|