国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (5): 571-578.doi: 10.7518/gjkq.2018.05.013

• 综述 • 上一篇    下一篇

植物雌激素防治牙周炎的研究进展

姜懿轩1,莫龙义2,贾小玥3,徐欣3,刘程程4()   

  1. 1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院种植科 成都 610041
    2. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院 成都 610041
    3. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科 成都 610041
    4. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周科 成都 610041
  • 收稿日期:2017-11-04 修回日期:2018-04-11 出版日期:2018-09-01 发布日期:2018-09-20
  • 通讯作者: 刘程程 E-mail:liuchengcheng519@163.com
  • 作者简介:姜懿轩,硕士,Email:531935636@qq.com
  • 基金资助:
    国家自然科学基金(81600871);国家自然科学基金(81771099);四川省科学技术厅项目(2016JY0006);四川省科学技术厅项目(2017029)

Prevention and treatment for periodontitis by phytoestrogens

Yixuan Jiang1,Longyi Mo2,Xiaoyue Jia3,Xin Xu3,Chengcheng Liu4()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    4. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-11-04 Revised:2018-04-11 Online:2018-09-01 Published:2018-09-20
  • Contact: Chengcheng Liu E-mail:liuchengcheng519@163.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81600871);This study was supported by National Natural Science Foundation of China(81771099);Scientific Research Foundation of the Science and Technology Department of Sichuan Province(2016JY0006);Scientific Research Foundation of the Science and Technology Department of Sichuan Province(2017029)

摘要:

雌激素代谢紊乱是牙周炎的全身促进因素。应用雌激素替代治疗可增加牙槽骨骨量,延缓牙周病进程,然而其安全性难以评估。植物雌激素是一种天然的雌激素类似物,包括大豆异黄酮、香豆素、木脂素等,可与人体内雌激素受体结合发挥相应的雌激素效应。近年来,越来越多的研究证据表明,外源性补充植物雌激素有可能缓解牙周炎症和组织破坏,为牙周炎治疗提供新的思路。本文就植物雌激素在牙周炎症及牙周组织破坏方面的研究进展进行综述。

关键词: 植物雌激素, 牙周炎, 雌激素受体, 牙槽骨, 雌激素替代治疗

Abstract:

Estrogen metabolism disorder is the systemic promoting factor of periodontitis. Application of estrogen replacement treatment can increase the alveolar bone mass and delay the progression of periodontal disease. However, its biosafety is difficult to assess. Phytoestrogens are natural plant compounds that are similar to estrogen, including soy isoflavones, coumarins and lignans, etc. They have estrogen-like activity by binding with estrogen receptor. Recently, increasing evidence have been found indicating exogenous phytoestrogens could relieve periodontal inflammation and tissue destruction. They offer a promising therapy for periodontitis. Thus, we colligate correlated documents and write the review.

Key words: phytoestrogen, periodontitis, estrogen receptor, alveolar bone, estrogen replacement treatment

中图分类号: 

  • R781.4 +2
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[3] 王昆润. 修补颌骨缺损的新型生物学相容材料[J]. 国际口腔医学杂志, 1999, 26(06): .
[4] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[5] 王昆润. 咀嚼口香糖对牙周组织微循环的影响[J]. 国际口腔医学杂志, 1999, 26(06): .
[6] 宋红. 青少年牙周炎外周血分叶核粒细胞的趋化功能[J]. 国际口腔医学杂志, 1999, 26(06): .
[7] 高卫民,李幸红. 发达国家牙医学院口腔种植学教学现状[J]. 国际口腔医学杂志, 1999, 26(06): .
[8] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[9] 温秀杰. 氟化物对牙本质脱矿抑制作用的体外实验研究[J]. 国际口腔医学杂志, 1999, 26(05): .
[10] 轩东英. 不同赋形剂对氢氧化钙抗菌效果的影响[J]. 国际口腔医学杂志, 1999, 26(05): .