国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (1): 46-49.doi: 10.7518/gjkq.2018.01.009
郝奕霖, 房付春, 吴补领
Hao Yilin, Fang Fuchun, Wu Buling
摘要: 人牙周膜来源细胞是一个异质性细胞群,能够分化成成骨细胞,参与牙槽骨改建、修复和牙周再生。微小RNA(miRNA)被认为在细胞调控分化进程中发挥了关键作用,也是维持细胞分化特性和调节分化的关键因子,miRNA靶向结合目的基因,通过上调或下调的调控方式产生促进或抑制成骨的作用。本文总结目前miRNA在人牙周膜来源细胞成骨分化过程中的相关研究,就miRNA在矿化或机械力诱导作用条件下可能发挥的功能、调控的靶基因及通路进行综述。
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