国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (6): 674-678.doi: 10.7518/gjkq.2017.06.010

• 牙周专栏 • 上一篇    下一篇

齿垢密螺旋体糜蛋白酶样蛋白酶复合物及其致病作用

苗棣1,2, 吴亚菲3   

  1. 1.西安交通大学口腔医院陕西省颅颌面精准医学研究重点实验室 西安 710004;
    2.西安交通大学口腔医院牙周黏膜科 西安 710004;
    3.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2017-01-20 修回日期:2017-08-15 出版日期:2017-11-01 发布日期:2017-11-01
  • 通讯作者: 吴亚菲,教授,博士,Email:yfw1110@163.com
  • 作者简介:苗棣,主治医师,博士,Email:corchorus@hotmail.com
  • 基金资助:
    西安交通大学基本科研业务费自由探索类项目(xjj20130- 68)

Treponema denticola chymotrypsin-like protease complex and its pathogenic features

Miao Di1,2, Wu Yafei3   

  1. 1. Key Laboratory of Shanxi Province for Craniofacial Precision Medicine Research, Stomatological Hospital of Xi’an Jiaotong University, Xi’an 710004, China;
    2. Dept. of Periodontics and Mucosa Disease, Stomatological Hospital of Xi’an Jiaotong University, Xi’an 710004, China;
    3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-01-20 Revised:2017-08-15 Online:2017-11-01 Published:2017-11-01
  • Supported by:
    This study was supported by Fundamental Research Funds of Xi’an Jiaotong University for Free Exploration Pro-ject(xjj2013068).

摘要: 齿垢密螺旋体作为龈下菌斑红色复合体中的一员,与牙周炎症密切相关。其表面的糜蛋白酶样蛋白酶复合物(CTLP)是齿垢密螺旋体的一个重要的毒力因子。CTLP参与介导了齿垢密螺旋体的多种致病机制,包括对组织细胞和组织蛋白的黏附及侵入,与其他牙周致病菌协同形成致密生物膜,产生细胞毒作用,破坏上皮屏障、侵入深层牙周组织,降解组织蛋白,调节宿主源性蛋白酶的激活,引发宿主的免疫调控紊乱,具有多方面的致病作用。深入研究CTLP,有助于诠释口腔螺旋体的致病机制,丰富牙周病的病因及发病机制。

关键词: 牙周病, 齿垢密螺旋体, 糜蛋白酶样蛋白酶复合物

Abstract: Treponema denticola is closely associated with periodontal disease as a member of subgingival “red complex”.The surface protease chymotrypsin-like protease complex(CTLP) is an important virulent factor of T. denticola. CTLP plays significant roles in mediating pathogenesis of T. denticola, including adhesion and invasion to host cells and proteins, synergetic formation of biofilm with other periodontal pathogens, cytopathic effect, impairment and penetration of epithelial barrier, degradation of cell and tissue protein, modulation of host-derived proteinases and disruption of host immune regulation, and displaying multiple pathogenic features. Further study of CTLP will help to explain the pathogenesis of oral leptospira and to enrich the etiology and pathogenesis of periodontal diseases.

Key words: periodontal disease, Treponema denticola, chymotrypsin-like protease complex

中图分类号: 

  • Q51
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