Int J Stomatol

Int J Stomatol ›› 2026, Vol. 53 ›› Issue (2): 266-273.doi: 10.7518/gjkq.2026108

• Reviews • Previous Articles    

Research progress on dental implants in patients with chronic liver diseases

Xueqi Guo1,2(),Yi Man1()   

  1. 1.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.Dept. of Implantology, School and Hospital of Stomatology, Guangzhou Medical University, Guangdong Enginee-ring Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou 510182, China
  • Received:2024-09-01 Revised:2025-07-22 Online:2026-03-01 Published:2026-02-13
  • Contact: Yi Man E-mail:drguoxueqi77@126.com;manyi780203@126.com
  • Supported by:
    National Key Research and Development Program of China(2023YFC3605600);Clinical Research Pro-ject of West China Hospital of Stomatology, Sichuan University(LCYJ-ZD-202303)

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Abstract:

Despite the global decline in the incidence of viral hepatitis due to improved public health conditions, over one-fifth of the population in China continues to suffer from chronic liver diseases (CLDs), including hepatitis B, hepatitis C, cirrhosis, and liver cancer. In selecting appropriate oral implant treatments for these patients, the effects of the primary disease and its complications on implant osseointegration and the influence of relevant therapeutic medications on bone metabolism must be considered. This work aims to explore these factors and review the implant treatment process, success and survival rates, and perioperative preparations for patients with CLDs to provide valuable clinical insights for oral implant practitioners.

Key words: chronic liver disease, oral implant, osseointegration, immunosuppressant

CLC Number: 

  • R783.4

TrendMD: 

Fig 1

Liver transplantation patient with 26 tooth sites implantation repair"

Tab 1

Effects of therapeutic drugs for chronic liver disease on implant surgery and clinical treatment measures"

药物种类代表药物影响应对措施
抗病毒药物NA恩替卡韦、替诺福韦酯肾脏损伤→低磷血症→骨质疏松风险↑监测骨密度；补充磷制剂及维生素D；必要时更换药物（需咨询内科医生）
IFN＿甲状腺功能障碍→骨代谢紊乱→骨质疏松风险↑术前筛查甲状腺功能（尤其高龄女性）；调整治疗方案
免疫抑制剂GC泼尼松抑制成骨细胞活性→骨量减少；增加破骨细胞活性→骨吸收↑；诱发骨质疏松若每日服用泼尼松≥5 mg，建议暂缓种植手术
CNI环孢霉素、他克莫司甲状旁腺激素分泌↑→骨密度↓；诱发胰岛素抵抗→肝移植后糖尿病监测血糖及骨代谢指标；延长愈合时间，采用渐进性负荷
抗骨质疏松药物雌激素受体调节剂雷洛昔芬选择性雌激素调节→骨转化率↓缺乏长期临床证据，谨慎评估骨代谢状态
BP—长期使用→颌骨坏死风险↑用药史<4年者可行简单手术；>4年者需停药≥2个月，采用微创手术；静脉注射应暂缓种植
单克隆抗体地舒单抗抑制破骨细胞分化→骨代谢紊乱→颌骨坏死风险↑尚无明确共识，高剂量者尽量采用保守修复策略
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