Int J Stomatol

Int J Stomatol ›› 2022, Vol. 49 ›› Issue (3): 290-295.doi: 10.7518/gjkq.2022034

• Microbiology • Previous Articles     Next Articles

Research progress on the interactions between Enterococcus faecalis and other oral microorganisms

Liu Qianxi1(),Wu Jiayi2,Ren Biao3,Huang Ruijie1()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    3.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-06-01 Revised:2021-11-22 Online:2022-05-01 Published:2022-05-09
  • Contact: Ruijie Huang E-mail:980098145@qq.com;hwangrj@163.com
  • Supported by:
    National Natural Science Foundation of China(NSFC31800114);Sichuan University Innovation and Entrepreneurship Training Program under Grants(202010611316)

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Abstract:

Interactions among different oral microbes play an important role in the occurrence and development of oral diseases. Enterococcus faecalis contributes to various inflammatory diseases by forming biofilm and secreting harmful substances, including gelatinase and cytolysin. It becomes an opportunistic pathogen in case of low immunity. Enterococcus faecalis can be detected together and interact with other pathogenic microbes, such as Candida albicans, Staphylococcus aureus, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Streptococcus mutans from a series of oral lesions, including pulpitis, periapical periodontitis and periodontitis. This review summarised the research progress on studies about the interactions between Enterococcus faecalis and other oral pathogens and focuses on their combination effects in oral diseases to provide a new version for clinical prevention and treatment.

Key words: Enterococcus faecalis, Candida albicans, microbial interaction, oral disease

CLC Number: 

  • R 37

TrendMD: 

Tab　1

Mechanism and manifestation of synergistic pathogenesis between Enterococcus faecalis and common oral pathogens"

检出病灶菌种作用机制作用表现对疾病的影响
根尖周炎粪肠球菌与白色念珠菌基因ROB1、NDT80、BRG1和ALS3的表达上调

生物膜增大增厚

侵袭力增强

降低机体免疫应答

感染迁延不愈
粪肠球菌与变异链球菌—

生物膜增大增厚

抗药性增强

促进感染进展

抗菌药疗效降低

粪肠球菌与戈登链球菌pAM373质粒转移耐药性增强抗生素疗效降低
粪肠球菌与金黄色葡萄球菌vanA质粒转移耐药性增强抗生素疗效降低
牙周炎粪肠球菌与牙龈卟啉单胞菌、伴放线放线杆菌上调人体IRAK-M的表达降低机体免疫应答

感染迁延不愈

难治性牙周炎

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