Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (6): 673-677.doi: 10.7518/gjkq.2018.06.009

• Materials • Previous Articles     Next Articles

Mechanism and application of osteogenesis induced by graphene and its derivatives modified composite materials

Tingting Li,Yufeng Zhang(),Ruoxi Wang,Zhiqing Huang,Lü Xie,Yifan Xue,Yulan Wang   

  1. State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatolgy, Wuhan University, Wuhan 430079, China
  • Received:2017-11-02 Revised:2018-05-23 Online:2018-11-01 Published:2018-11-15
  • Contact: Yufeng Zhang E-mail:zyf@whu.edu.cn
  • Supported by:
    This study was supported by Fundamental Research Funds for the Central Universities(2042017kf0207);The Special Fund for Technical Innovation of Hubei Province(2017AHB046)

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Abstract:

For a long time, autogenous bone graft is widely used in clinic and was verified to be effective in treating bone defects, but this technique is not perfect for the difficulty in healing of the donate site, immune rejection and infection. Bone tissue engineering approaches aims to aid the regeneration of bone tissues by filling the bone defects with different scaffolds which is able to induce the osteogenic differentiation of bone marrow stem cells. It is reported in former researches that graphene coating can significantly enhance the biocompatibility, cell adhesion and differentiation of scaffolds. In this review, we focused on the application of scaffolds modified with graphene and its derivatives to promote osteogenic differentiation published in recent years to providing new ideas for bone tissue regeneration.

Key words: graphene, grapheme derivatives, osteogenic differentiation, osteogenesis

CLC Number: 

  • R687.3 +4

TrendMD: 
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