Int J Stomatol

Int J Stomatol ›› 2026, Vol. 53 ›› Issue (3): 441-448.doi: 10.7518/gjkq.2026220

• Reviews • Previous Articles    

Research progress in the regulatory role of microRNA-143/145 gene cluster in signaling pathways of oral squamous cell carcinoma

Wendi Guo1,2(),Lu Qi2,3,Xing Wang1,2()   

  1. 1.Dept. of Prosthodontics and Implant Dentistry, the First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatology Hospital), Urumqi 830054, China
    2.Stomatology Research Institute of Xinjiang Uygur Autonomous Region, Urumqi 830054, China
    3.Dept. of Stomatology, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China
  • Received:2024-12-04 Revised:2025-03-18 Online:2026-05-01 Published:2026-04-24
  • Contact: Xing Wang E-mail:iuwdjiu@163.com;40275668@qq.com

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Abstract:

Oral squamous cell carcinoma (OSCC) is the most prevalent malignant neoplasm in the oral and maxillofacial region. Traditional surgical excision remains the primary treatment because of the lack of specific therapeutic approaches. However, the resultant oral and maxillofacial defects severely impact patients’ quality of life. Therefore, elucidating the molecular mechanisms regulating OSCC development is crucial. microRNA (miRNA)-143 and miRNA-145 are aberrantly expressed in OSCC and significantly participate in its pathogenesis. Studying the expression and target gene regulation of miRNA-143 and miRNA-145 in OSCC may help clarify its molecular mechanisms, confirm their value as biomarkers and molecular targets, and provide new insights for clinical diagnosis and treatment.

Key words: microRNA-143, microRNA-145, oral squamous cell carcinoma, signaling pathway, target gene

CLC Number: 

  • Q257

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Fig 1

The synthesis of miRNA"

Fig 2

Regulation of miRNA function"

Tab 1

The differential expression of miR-143 and miR-145 in OSCC"

研究者时间/年来源方法miRNA表达
Yu等[26]20093例OSCC动物模型和3例正常动物模型qRT-PCRmiR-143、miR-145下调
Gao等[30]201362例OSCC组织样本qRT-PCRmiR-145下调
邵渊等[31]2014口腔癌细胞株CAL27qRT-PCRmiR-145下调
Wang等[28]2016暴露于槟榔碱的口腔上皮细胞株（AOE）qRT-PCRmiR-145下调
Sun等[25]201715例OSCC组织样本和15例正常口腔黏膜组织样本qRT-PCRmiR-143下调
Mesgarzadeh等[24]2019口腔癌细胞株HN-5qRT-PCRmiR-143下调
Singh等[27]202350例OSCC组织样本和20例正常口腔黏膜组织样本qRT-PCRmiR-145下调
刘岚等[29]2024102例OSCC组织样本和86例正常口腔黏膜组织样本qPCRmiR-145下调

Fig 3

Regulation of miR-143 and miR-145 on downstream target genes"

Fig 4

The upstream regulation of miR-143 and miR-145"

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