Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (6): 756-762.doi: 10.7518/gjkq.2024076

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Research progress on the role and mechanism of pannexins in regulating oral and orofacial pain

Yuheng Feng(),Fei Liu,Yanyan Zhang,Jiefei Shen()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-04-08 Revised:2024-05-23 Online:2024-11-01 Published:2024-11-04
  • Contact: Jiefei Shen E-mail:Fqqaioth@163.com;shenjiefei@scu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81870800)

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Abstract:

The pathological mechanism of orofacial pain is complex, and long-lasting effective clinical treatment me-thods are lacking, causing a heavy burden on patients’ lives. Pannexins (PANX), which are broadly expressed in the peri-pheral and central nervous systems, play a crucial role in regulating the development of orofacial pain. This review focuses on the structure and function of PANX as well as its role and mechanism in pain, including neuropathic pain, inflammatory pain, and other orofacial pain. We aim to provide a theoretical basis and treatment strategies for the diagnosis and treatment of orofacial pain by gaining a deep understanding of the role and function of PANX.

Key words: pannexin, orafacial neuropathic pain, signaling pathways, trigeminal ganglion

CLC Number: 

  • R78

TrendMD: 
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[1] LIU An -dong, LEI Jie, WANG Yuan-yin, ZHOU Jian. Research progress of trigeminal neuralgia and P2X receptors [J]. Inter J Stomatol, 2010, 37(02): 174-174～177.
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