Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (02): 174-174～177.doi: 10.3969/j.issn.1673-5749.2010.02.014

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Research progress of trigeminal neuralgia and P2X receptors

LIU An -dong, LEI Jie, WANG Yuan-yin, ZHOU Jian   

  1. Dept. of Oral and Maxillofacial Surgery, College of Stomatology, The Affiliated H
  • Received:2009-06-13 Revised:2009-10-14 Online:2010-03-20 Published:2010-03-20
  • Contact: 王元银

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Abstract: A variety of noxious stimulation can cause adenosine triphosphate（ATP） release from the cells. ATP can create correlative biological effect via P2X and P2Y receptors. Both of P2X and P2Y receptors are belonged to the P2 receptor family. The P2X receptors are non-selective cation channel receptors which can permit positive ion, such as Na+, Ca2+ and K+, to pass. P2Y receptors are a kind of G-protein-coupled receptors. Peripheral pain usually occurs in the most of middle and small neurons of the conduction of the trigeminal ganglion. Here, the recent developments of P2X receptors′ structure, distribution and biological character of trigeminal ganglion neurons were reviewed.

Key words: adenosine triphosphate, P2X receptor, ligand-gated ion-channel, trigeminal ganglion

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