Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (3): 320-320～323.doi: 10.3969/j.issn.1673-5749.2010.03.021

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Research progress on hypoxia -inducible factor -1α

ZOU Duo -hong1,2, HUANG Yuan -liang2.   

  1. 1. School of Stomatology, Tongji University, Shanghai 200072, China
    2. Dept.
  • Received:2009-12-11 Revised:2010-02-22 Online:2010-05-20 Published:2010-05-20
  • Contact: HUANG Yuan -liang

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Abstract: Under the condition of anaemia, trauma, necrosis and defect, cells and tissues are often in mionectic condition. Hypoxia in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, cell growth and proliferation. Among these genes, HIF-1α plays crucial roles in the angiogenesis of tumors and mammalian development. Recently year, it is found that besides inducing angiogenesis, HIF-1α has effect on osteogenesis. This review focused on the molecular structure, downstream target genes, osteogenesis of HIF-1α.

Key words: hypoxia inducible factor-1α, angiogenesis, osteogenesis

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